| Project/Area Number |
06807073
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | UNIVERSITY OF TOKUSHIMA |
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Principal Investigator |
NISHITANI Hiromu Univ.of Tokushima, Sch.of Medicine, Professor, 医学部, 教授 (50117206)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Hirokazu Univ.of Tokushima School of Medical Sciences, Research Associate, 医療短期大学部, 助手 (90229906)
HARADA Masafumi Univ.of Tokushima, Univ.Hospital of Sch.of Medicine, Assistant Professor, 医学部, 講師 (20228654)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | 19F-MRI / 19F-MRS / 5-FLUOROURACIL / FBAL / TUMOR / 5-FU / 腫瘍 / 治療評価 / MRI / フッ素化合物 / 肝臓 |
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| Research Abstract |
(1) Imaging of 19F-MR
Spin echo sequence could not be used for imaging of 19F-MR,because of difficulty of adjustment of 180-degree pulse by surface coil. We chose FISP,which is one of method of gradient echo sequence, for imaging. The condition for measurement was as follows ; TR=50ms, TE=7.5ms, Flip angle 10ﾟ. The lowest limitation of concentration for imaging was about 20mM,and gradation of sensitivity by surface coil was also observed. This result was the seme as images of 1H-MR.
(2) The evaluation of tumor therapy by 19F-MRS
The spectra of 19F were able to be obtained from the liver and urinarry bladder, but to make image was impossible because the concentration would be under limitation of the instrument. We conducted a study by the animal model of implanted tumor. The peak of 5-fluorouracil (5-FU) was high in the tumor and the decrease rate of 5-FU was slower than that in the normal tissue. The peak of fluoronucleotide was not observed in the tumor. In the liver tumor model, the decrease of 5-FU and increase of FBAL were slower than those in the normal liver. We considered that the retention of 5-FU in the tumor become an index of therapeutic effect, because high concentration of 5-FU causes inhibition of tumor growth and dose-dependent efficathy of 5-FU has been reported.
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