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コスタリカ(中米諸国)におけるヘリコバクター・ピロリ感染と消化管疾患の病態解析

Research Project

Project/Area Number 06F06248
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Laboratory medicine
Research InstitutionKochi University

Principal Investigator

杉浦 哲朗  Kochi University, 医学部, 教授

Co-Investigator(Kenkyū-buntansha) SERGIO A. CON CHIN  高知大学, 医学部, 外国人特別研究員
CON CHIN Sergio A.  高知大学, 医学部, 外国人特別研究員
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsコスタリカ / ヘリコバクター・ピロリ / 消化管疾患 / ピロリ遺伝子多型性 / 宿主遺伝子多型性 / 血清ペプシノーゲン / 病原性 / 宿主免疫応答
Research Abstract

胃癌の高頻度発症国であるコスタリカでの胃内ヘリコバクター・ピロリ菌感染と消化管疾患発症との関連性について研究している。これまでに、コスタリカ人から分離されたピロリ菌の2遺伝子(cagAとvacA(s1/ml))。保有率はEurope/North AmericaとEast Asiaの中間に位置しており、vacA s1bとvacA m1型遺伝子保有ピロリ菌感染と胃癌群との間に関連性を認めた。一方でvacA m1型のみが萎縮性胃炎と関連性を認め、統計学上は有意差を示さなかったが、cagA/vacA s1b型と萎縮性胃炎の間にも関連性を示す傾向が判明した。(論文発表)
また、Low-PG(血清ペプシノーゲン値)、Very Low-PG、ピロリCagA抗体は、個々に萎縮性胃炎と腸上皮化生との間に関運性を示したが、サイトカインであるIL-1B+3954T保有者とIL-1RN(ホモで2つのアレル保有者)は腸上皮化生とのみに関連性を示した。さらに、胃体部の萎縮性胃炎を検出するためのVL-PG値は、sensitivity(77.4%)、specificity(80.7%)、PPV(39.3%)、NPV(95.7%)と良好な検査診断法(マーカー)と考えられた。また、VL-PG値にピロリCagA抗体の結果を加えることにより、sensitivity(74.2%)、specificity(92.7%)、PPV(62.2%)、NPV(95.7%)となりさらに特異性が向上した。以上より、胃癌のハイリスクである胃体部の萎縮性胃炎を検出・診断するためには血清ペプシノーゲンの周期的な測定のみか、或いはピロリCagA抗体測定との組み合わせ検診がコスタリカにおける検診として最も適していると考えられた。(論文発表)

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (9 results)

All 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Diversity of Helicobacter pylori cagA and vacA Genes in Costa Rica: Its Relationship with Atrophic Gastritis and Gastric Cancer2007

    • Author(s)
      Con Chin SA., Takeuchi H., Valerin AL, Con Wong R., et. al.
    • Journal Title

      Helicobacter 12

      Pages: 547-552

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Pepsinogen Levels, Helicobacter pylori CagA Status and Cytokine Gene Polymorphisms Associated with Gastric Premalignant Lesions in Costa Rica2007

    • Author(s)
      Con Chin SA., Con Wong R., Con Chin GR., Con Chin VG., Takeuchi H., et. al.
    • Journal Title

      Cancer Epidemiology Biomarkers and Prevention 16

      Pages: 2631-2636

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori CagA status associated with gastric cancer incidence rate variability in Costa Rican regions2006

    • Author(s)
      Con SA, Valerin AL, Takeuchi H, et al.
    • Journal Title

      J Gastroenterol. 41・7

      Pages: 632-637

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cell elongation and cell death of Helicobacter pylori is modulated by the disruption of cdrA (cell division-related gene A)2006

    • Author(s)
      Takeuchi H, Nakazawa T, Okamoto T, et al.
    • Journal Title

      Microbiol Immunol. 50・7

      Pages: 487-497

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secretory IgA, salivary peroxidase, and catalase-mediated microbicidal activity during hydrogen peroxide catabolism in viridans streptococci : pathogencoaggregation2006

    • Author(s)
      Uehara Y, Agematsu K, Kikuchi K, et al.
    • Journal Title

      J Infect Dis. 194・1

      Pages: 98-107

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Morphological observations and the effects of artificial digestive fluids on the survival of Diploscapter coronata from a Japanese patient2006

    • Author(s)
      Morimoto N, Korenaga M, Yagyu K, et al.
    • Journal Title

      J Helminthol. 80・4

      Pages: 341-348

    • Related Report
      2006 Annual Research Report
  • [Presentation] Clinical relevance of babA2, babB and a recombination between babA2 and babB genes of Helicobacter pylori: Studies in Costa Rica and Japan.2007

    • Author(s)
      Con Chin SA., Takeuchi H., et. al.
    • Organizer
      107th ASM General Meeting (American Society for Microbiology)
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Serum Pepsinogen Levels, Helicobacter pylori CagA Status and Cytokine Gene Polymorphisms Associated with Gastric Premalignant Lesions in Costa Rica2007

    • Author(s)
      Con Chin SA., Takeuchi H., Con Wong R., et. al.
    • Organizer
      7th IGCC (International Gastric Cancer Congress)
    • Place of Presentation
      Sao Paulo, Brazil
    • Related Report
      2007 Annual Research Report
  • [Presentation] Prevalence of Helicobacter pylori cagA, vacA, babA2 and babB genes: association with gastric atrophy and recombination of babA2 and babB in Costa Rica2006

    • Author(s)
      Con Chin SA., Takeuchi H., Valerin AL., et. al.
    • Organizer
      106th ASM General Meeting (American Society for Microbiology)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2024-03-26  

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