Grant-in-Aid for International Scientific Research.
|Section||Special Cancer Research|
|Research Institution||Kagoshima University|
SONODA Shunro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (40036463)
LUIS Hurtad ボリビア医学会, 名誉教授
WILLIAM J.Ha マイアミ大学, 医学部・内科学, 助教授
ABRAHAM Blan バジェ大学, 医学部, 準教授
VLADIMIR Zan バジェ大学, 医学部・内科学, 教授
BARRIE Hanch ウエストインデイー大学, 医学部・病理学, 教授
YASHIKI Shinji Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (40182315)
FUJIYOSHI Toshinobu Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50173480)
TAKEZAKI Toshiro Aichi Cancer Center Research Institute, Division of Epidimiology, scholar, 研究員 (50227013)
HAYAMI Masanori Kyoto University, Institute for virus Research, Professor, ウイルス研究所, 教授 (40072946)
LUIS Hurtado ボリビア医学会, 名誉教授
BYRNES John マイアミ大学, 医学部, 教授
HANCHARD Bar ウエストインディー大学, 医学部, 教授
|Project Fiscal Year
1995 – 1997
Completed(Fiscal Year 1997)
|Budget Amount *help
¥11,900,000 (Direct Cost : ¥11,900,000)
Fiscal Year 1997 : ¥4,000,000 (Direct Cost : ¥4,000,000)
Fiscal Year 1996 : ¥4,300,000 (Direct Cost : ¥4,300,000)
Fiscal Year 1995 : ¥3,600,000 (Direct Cost : ¥3,600,000)
|Keywords||HTLV-I / HLA / Andes Natives of South American / Easter Island / HAM / TSP / ATL / disease susceptibility / ethnoeoidemiology / 南米アンデス先住民 / イ-スター島住民 / 疾患感受性 / 民族疫学 / II / アンデス先住民 / ジャマイカ黒人 / HLAハプロタイプ / 疾病感受性 / モンゴロイド|
In order to elucidate the susceptibility to HTLV-I/II infection and diseases, we investigated HTLV-I and II infection foci amang South American and Caribbean populations. In this study, we have collected blood samples from the Andes native populations of Bolivia, Peru, Colombia, Chile and Argentina, the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile, as well as Black population of Jamaica, Colombia and Brazil, under informed consent.
HTLV-I foci were found among the Andes native populations of Bolivia, Peru, colombia, chile and Argentina. On the otherhand, HTLV-II foci were identified among the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile. Thus, the distribution of HTLV-I and HTLV-II foci are geographically sagregated each other. HLA background of HTLV-I carriers of the South American natives showed common HLA class I and II alleles of HTLV-I carriers of Southern Japanese and ethno-specific HLA alleles.
We investigated HTLV-I immunoepitopes recognized by the HLA alleles at risk for ATL and HAM/TSP.Thus, HLA class I A26^<**>, B^<**>4002/6 were at risk for ATL and rhese HLA alleles lacked anchor motifs in HTLV-I Tax peptides. While HLA class I A24, B^<**>07 were at risk for HAM/TSP and these HLA alleles showed many anchor motifs in HTLV-I Tax peptides.
The blood samples collected in this study have been consisted of live lymphocytes bank and plasma bank, which are available for seroepidemiolgical examination and immunogenetical analysis.