| Project/Area Number |
07044269
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Research Institute for Radiation Biology and Medicine, Hiroshima University |
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Principal Investigator |
IMAMURA Nobutaka Research Institute for Radiation Biology and Medicine, Hiroshima University, 原爆放射能医学研究所, 講師 (60110821)
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| Co-Investigator(Kenkyū-buntansha) |
BEBESHKO Via Ukrainian Research Center for Radiation, 所長
KIMURA Akiro Research Institute for Radiation Biology and Medicine, Hiroshima University, 原爆放射能医学研究所, 教授 (70127645)
BEBESHKO Vladimir.G Ukrainian Research Center for Radiation Medicine Institute of clinical Radiology
BEBESHKO Vla Ukrainian Research Center for Radiation, 所長
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Acute myelogenous leukemia / acute lymphoblastic / chronic myelogenous / chronic lymphocytic / myelodysplastic syndrome / liquidator (clean up workers) / Kiev / malignant hematological disorders |
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| Research Abstract |
In Ukrainian Center for Radiation Medicine in Kiev (Director Bebeshko), Prof.Klimenko has been examining 120,000 liquidators in every year. They were set to be lower than 25 mSv irradiation, however, it was suggested that some of them exposd more than 100 mSv irradiation. I co-investigated those liquidators and found 141 patients with leukemia until 1993. Among them, 86 patients were diagnosed as acute leukemia.
During from 1993 to 1995, we found 42 patients with hematological malignancies. They were 16 cases of acute myelogenous leukemia, which were classified as AML M1 (2 cases), AML M2 (2 cases), AML M3 (2 cases), AML M4 (5 cases) according to FAB classification, AML M5 (4 cases), respectively. We found 2 cases of acute lymphoblastic leukemia (ALL L2 ; FAB). We found 8 patients with chronic myelogenous leukemia and 8 patients with chronic lymphocytic leukemia. We analyzed 2 cases of AML and found that deletion of exon 5 and exon 6 of p53 suppressor oncogene.
On the bases of these finding, it is suggested that the incidence of leukemia among liquidators is increasing tendency, recently.
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