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Development of Vaccine againest New Serotype O139 Bengal of Vibrio cholerae

Research Project

Project/Area Number 07044302
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionInternational Medical Center of Japan

Principal Investigator

TAKEDA Yoshifumi  International Medical Center of Japan, 所長 (30029772)

Co-Investigator(Kenkyū-buntansha) NAIR G.B  National Institute of Cholera and qutoric Diseaser, India, 副所長
BHATTACHARYA S.K  National Institute of Cholera and qutoric Diseaser, India, 所長
YAMASAKI Shinji  International Medical Center of Japan, 室長 (70221653)
YAMAMOTO Tatsuo  International Medical Center of Japan, 部長 (80095843)
NAIR G.B.  インド国立コレラ及び腸管感染症研究所, 副所長
BHATTACHAYE  インド国立コレラ及び腸管感染症研究所, 所長
BHATTACHARYA  インド国立コレラ及び腸管感染症研究所, 所長
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1996: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1995: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsNew Vibrio cholerae / O139 Bengal / Vibrio cholerae O1 / Vaccine / O antigen / O139ベンガル型 / 抗原変換 / パルスフィールドゲル電気泳動 / RFLP
Research Abstract

Vibrio cholerae O139 Bengal, a new serotype of cholerae vibrio, was first isolated in 1992 in India and it spread all over the Indian subcontinent during the first half of the year 1993. However, during the second half of 1993, V.cholerae O1 dominated and, in 1994 and 1995, most of V.cholerae isolated from cholera patients in the Indian subcontinent were V.cholerae O1. In the fall of 1996, we witnessed the resurgence of V.cholerae O139 Bengalin Calcutta, India.
Epidemiological survey of such a change of serotypes of V.cholerae provided an important information to develop a candidate vaccine against V.cholerae O139.
Genetic analysis of V.cholerae O1 and O139 showed that strains of V.cholerae O1 isolated during 1994-1995 resembled in their RFLP patterns to those of V.cholerae O139 but not to those of V.cholerae O1 isolated before the emergence of V.cholerae O139 on 1993.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] A.K.Mukhopadhyay: "Temporal shifts in traits of Vibrio cholerae strains isolated from hospitalized patients in Calcutta" Journal of Clinical Microbiology. 34. 2537-2543 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] R.Mitra: "Resurgence of Vibrio cholerae O139 Bengal with altered antibiogeom in Calcutta,India" The Lancet. 348. 1181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shinji Yamasaki: "Cryptic appearance of a new clone of Vibrio cholerae serogroup O1 biotype eltor in Calcutta,India" Microbiology and Immunology. 41. 1-6 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shingo Yamamoto: "Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diar sheagenicity but retain adjnvanticity" Journal of Experimental Medicine. 185. 1-8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shingo Yamamoto: "A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity" Proceedings of National Academy of Sciences,VS. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.K.Mukhopadhyay et al.: "Temporal shifts in traits of Vibrio cholerae strains isolated from hospitalized patiants in Calcutta" Journal of Clinical Microbiology. 34. 2537-2543 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] R.Mitra et al: "Resurgence of Vibrio cholerae O139 Bengal with altered antibiogram in Calcutta, India" The Lancet. 348. 1181 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shinji Yamasaki et al.: "Cryptic appearance of a new clone of Vibrio cholerae serogroup O1 biotype eltor in calcutta, India" Microbiology and Immunology. 41. 1-6 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shingo Yamamoto et al.: "Mutants in the ADP-ribosyltrons ferase cleft of cholera toxin lack dianheagenicity but retain acyuranticity" Journal of Experimental Medicine. 185. 1-8 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shingo Yamamoto et al.: "A nantoxic mutant of cholera toxin clicits Vh2-type responses for enhanced mucosal immunity" Proceedings of National Academy of Sciences, US. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.K.Mukhopadhyay: "Temporal shinfts in traits of Vivrio cholerae strains isolated from hospitalized patients in Calcutta" Journal of Clinical Microbiology. 34. 2537-2543 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] R.Mitra: "Resurgence of Vivrio cholerae O139 Bengal with altered antibiogram in Calcutta,India" The Lancet. 348. 1181 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shiuji Yamasaki: "Cryptic appearance of a new clone of Vivrio cholerae serogroup O1 biotype eltor in Calcutta,India" Microbiology and Immunology. 41. 1-6 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shingo Yamamoto: "Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjunvanticity" Journal of Experimental Medicine. 185. 1-8 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shingo Yamamoto: "A nontoxic mutant of clolera toxin elicits Th2-type responses for enhanced mucosal immunity" Proceeding of National Academy of Sciencer,US. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Okuda: "Distribution of the cytolethal distending toxin A gene(cdt A)among species of Shigella and Vibrio" Microbial Pathogenesis. 18. 167-172 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Yamamoto: "Emergence of tetracycline resistance due to a multipla drug resistance plasmid in Vibrio cholerae O139" FEMS Smmunol.& Med.Microbiol. 11. 131-136 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] G.B.Nair: "Evaluation of DNA probes for specific detection of Vibrio cholerae O139 Benegal" J.Clin.Microbiol. 33. 2186-2187 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Yamamoto: "Survey of in votro susceptibilitias of Vibrio cholerae O1 and O139 to antimicrobial agents" Antimicrob.Agents & Chemetherapy. 39. 241-244 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.K.Mukhopadhyay: "Distribution and rivulence of Vibrio cholerae belonging to serogroups other than O1 and O139:A nation wide survey." Epidemiology & Infection. 114. 65-70 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] G.B.Nair: "Vibrio chalerae O139 Bengal:the new serogroup causing cholera" Rev.Med.Microbiol.7. 43-51 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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