• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Co-operative Research on Clinical Application and Functional Preservation of Heart and Heart-lung Transplantation

Research Project

Project/Area Number 07307015
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Tokyo

Principal Investigator

NAKAJIMA Jun (1997)  Universty of Tokyo Hospital Assistant Professor, 医学部・附属病院, 講師 (90188954)

古瀬 彰 (1995-1996)  東京大学, 医学部・附属病院, 教授 (70010163)

Co-Investigator(Kenkyū-buntansha) ISOBE Mitsuaki  Shinshu University Hospital Associate Professor, 医学部(病), 助教授 (80176263)
TAKAMOTO Shin-ichi  University of Tokyo Hospital Professor, 医学部(病), 教授 (60137833)
MATSUDA Hikaru  Osaka University Hospital Professor, 医学部(病), 教授 (00028614)
FUJIMURA Shigefumi  Tohoku University, Institute Development, Aging and cancer Professor, 加齢医学研究所・呼吸器研究分野, 教授 (40006078)
TABAYASHI Koichi  Tohoku University Hospital Professor, 医学部(病), 教授 (90142942)
開原 成允  東京大学, 医学部・附属病院, 教授 (30010234)
矢崎 義雄  東京大学, 医学部(病), 教授 (20101090)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥24,700,000 (Direct Cost: ¥24,700,000)
Fiscal Year 1997: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1996: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1995: ¥10,300,000 (Direct Cost: ¥10,300,000)
KeywordsHeart Transp lantation / Organ transp lantation network / Graft atherosclerosis / Cardiomyoathy / Immunosuppression / gene transfer / donation / Cardiac xenotransplantation / 渡航心移植 / 冠動脈硬化症 / 補助人工心臓 / Donation / 肺保存 / 異種心臓移植 / 心臓移植 / 肺移植 / 抗接着抗体 / 慢性拒絶反応 / 移植心冠状動脈硬化 / donor臓器
Research Abstract

Kaihara investigated information Network System for multi organ sharing and more appropriate to implement required features than a classical main frame, especially the details about handling informations on inter net system. Matsuda investigated graft coronary atherosclerosis is preset in the first several days of transplantation. Tabayashi and Isobe reported ACE inhibitor, Angiotensin II receptor antagonist, cell cycle gene decoy and anti adhesion molecule prevent graft atherosclerosis. Sano investigated the donor heart Function harvested after 1 hour of warm cardiac arrest. Taira reported feasibility of hyaluronidase fo rtified cardioplegia. Koyanagi studied new immunosuppressive agent. Kawashima and Nakatani reported two endostage cardiomyopathy cases. They were successfully treated with left ventricular assist device and still alive after weaning of the device. Furuse, Takamoto, Nakajima investigated discordant xenoheart transplantation in infantile monkeys. Hujimura, Eguchi, Yada experimentally investigated lung preservation and immunosuppressive therapy.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Suzuki J et al: "Non muscle and smooth muscle myosin heavey chain expression in ryected cardiac allografts" Circulation. 94. 1118-1124 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Isbe M et al: "Acceptance of primary skin graft after troatmod wid anti intercelludac adhesion molecules and anti-leucecyte function associated outigons mmoclonal antibodiesinmice" Transplantation. 62. 411-413 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawauchi M et al: "Antigonicity of heart values and vessels:A primate heart transplant study." Transplant Proc. 28. 1824-1825 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki J et al: "Prevention of graft coronary atheros clerosis by antisanse cdk2 kinase oligo nucleotide" Nature Medicine. 3. 900-903 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sawa Y et al: "A norel strategy for myocardial protection using in vivo franefection of cis element ,'Decoy'against NFKB Binding Site" Circulation. 96. II-280-II-285 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima J et al: "Role of costimul atory molecules on airway epithelial alls acting as alliantigon-presonting cells" Transplant Proc. 29. 2297-2300 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki J et al: "Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts." Circulation. 94. 1118-1124 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Isobe M et al: "Acceptance of primary skin graft after treatment with anti intercellular adhesion molecule-1 and anti-leucocyte function associated antigen 1 monoclonal antibodies in mice" Transplantation. 62. 411-413 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawauchi M et al: "Antigenicity of heart valves and vessels : A primate heart transplant study" Transplant Proc. 28. 1824-1825 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki J et al: "Prevention of graft coronary atherosclerosis by antisense cdk2 kinase oligonucleotide" Nature Medicine. 3. 900-903 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sawa Y et al: "A novel strategy for myocardial protection using in vivo transfection of cis element 'Decoy' against NFKB binding site" Circulation. 96. II-280-II-285 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima J et al: "Role of costimulatory molecules on airway epithelial cells acting as alloantigen presenting cells" Transplant Proc. 29. 2297-2300 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki J et al: "Prevention of graft coronary athereclever by antisense cdk2 kenase oligonucle eticle" Nature Medicine. 3(8). 900-903 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sawa Y et al: "A novel stragtegy for myocardial protection using in vivo transfection of vis element 'Decoy' against NFKB Bindirg Site" Circulation. 96(supple II). 280-285 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sawa Y et al: "Efficient gene transfer method into the whole heart through the coronary artery with hemagglutinating virus of Japanese liposime" J.Thorac.Cardiovasc.Surg.113(3). 512-519 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki J et al: "Early diagniris of cardiac rejection by in situ detection of non-muscle myoeior heavy chain transcription" Transplant Proc. 29. 1512-1512 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hachida M et al: "Significant effect of 1.4-Benzothiazepine derivative (K2) in improving myocardial preservation" Transplant Proc. 29. 1346-1348 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima J et al: "Role of costimulatory molecules on airway epithelial cells acting as allcantigen-prosenting cells." Transplant Proc. 29. 2297-2300 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki J et al: "Nonmuscle and smooth mucle myosin heavychain expression in rejected cardiac allegnalts-A study in rat and monlsay models" Circulation. 94(5). 1118-1124 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Izutani H et al: "Effect of recipient T cell subset depletion on graft coronary arteriosclerosis induction in the rat retransplant model." Transplantation Proceedings. 28(2). 1828-1829 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Isobe M et al: "Effects of exogenous IL-2 on tolerance induction by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies" Transplantation Proceedings. 28(2). 1045-1046 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Isobe M et al: "Acceptance of primary skin graft after treatment with anti-intercellular adhesion molocule-1 and anti-leucscyte function-associated antigen-1 monoclonal antibadies in mice" Transplantation. 62(3). 411-413 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawauchi M et al.: "Antigenicity of heart valuos and vessels:A primate heart transplant study" Transplant Proc. 28(3). 1824-1825 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawauchi M et al.: "Which are the target vessels of xeno-and allo-lung rejection?-A primate single lung transplantation study" Transplant Proc. 28(3). 1416-1417 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 坂田純一他: "Zfy-1 primerを用いた移植片由来Passenger heukocyte分析の解析" 札幌医学雑誌. 65(発表予定). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 八田光弘他: "心臓移植における新しい免疫抑制剤の有効性と移植合併症に関する実験的・臨床的検討" 日本胸部外科学会雑誌. 43. 688-690 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 川内基裕他: "異種心臓移植の現況と問題点" 今日の移植. 8. 275-280 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Izutani H. et al.: "Evidence that groft coronary atherosclerosis fegino in the early phase after transplantation and progresses without chronic immunoreaction" Transplantation. 60. 1073-1079 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Izutani H. et al.: "Graft coronary arteriosclerosis in rat heart transplant model with FK506 short-term administration" Transplant Proc. 27. 579-581 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakatani T et al.: "hong-term circulatory support to promote recovery from profound heart failure" ASAIO Journal. 41. M526-M530 (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi