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STUDIES ON MOLECULAR MECHANISMS AND PHYSIOLOGICAL FUNCTIONS OF ANTI-CELL ADHESION

Research Project

Project/Area Number 07308073
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Cell biology
Research InstitutionINSTITUTE FOR MOLECULAR SCIENCE OF MEDICINE,AICHI MEDICAL UNIVERSITY

Principal Investigator

KIMATA Koji  INSTITUTE FOR MOLECULAR SCIENCE OF MEDICINE,AICHI MEDICAL UNIVERSITY,PROFESSOR, 分子医科学研究所, 教授 (10022641)

Co-Investigator(Kenkyū-buntansha) SEKIGUCHI Kiyotoshi  RESEARCH INSTITUTE,OSAKA MEDICAL CENTER FOR MATERNAL AND CHILD HEALTH,DIRECTOR, 所長 (50187845)
OHIRA Atuhiko  DEPARTMENT OF PERINATOLOGY AND NEUROGLYCOSCIENCE,INSTITUTE FOR DEVELOPMENTAL RES, 発達障害研究所, 部長 (20101074)
SAKAKURA Teruyo  MIE UNIVERSITY SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (80073120)
KITAGAWA Yasuo  GRADUATE PROGRAM OF BIOCHEMICAL REGULATION,SCHOOL OF AGRICULTURAL SCIENCES,NAGOY, 生物分子応答研究センター, 教授 (50101168)
KAZUHIRO Nagata  CHEST DISEASE RESEARCH INSTITUTE,KYOTO UNIVERSITY,PROFESSOR, 胸部疾患研究所, 教授 (50127114)
祖父江 憲治  大阪大学, 医学部, 教授 (20112047)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥10,400,000 (Direct Cost: ¥10,400,000)
Fiscal Year 1996: ¥10,400,000 (Direct Cost: ¥10,400,000)
KeywordsCell adhesion / Anti-adhesion / Integrin / Extracellular matrix / Cell-substratum inteaction / Proteoglycans / Adhesion signal / kinases / 抗一接着 / レセプター
Research Abstract

Some of established cell lines are insensitive to anti-adhesive activity of chondroitin sulfate proteoglycans, and other lines are defective of annexin VI which is a candidate of the receptor for chondroitin sulfate chains with anti-adhesive activity. Those may be useful to analyze a possible role of annexin VI in anti-adhesion (Kimata). Transfection with antisense RNA for HSP-47 expression caused not only the decrease in collagen synthesis but also insolubilization of the collagen, which suggests a role of HSP-47 as shaperon (Nagata). Kitagawa analyzed the effect of the transfection with mutant laminin genes on the cell behaviors. Mammary carcinoma cells with high activity of tenascin production, compared to those with the low activity, showed the round cell morphology, the high activity of cell migration and the high invasiveness, which sugggests the effect of anti-adhesive activity of tenascin on the metastasis (Sakakura). In addition, differently from the anti-adhesion, RGD-indepen … More dent integrin may be involved in a cryptic cell-adhesive acitivity of tenascin (Obara). A novel membrane-bound proteoglycan, neuroglycan C influences cell adhesion in rat brain and may induce the neurite outgrowth (Oohira). lung carcinoma cells with the low metastatic activity usually show the high expression of syndecan and tend to show the organized stress fiber formation, but those with the high activity tend to induce the formation of ruffling membranes. The difference may explain a possible realationship between the cell adhesiveness and the metastatic ability of the carcinoma (Okayama). Sekiguchi has found that altemative splicing of fibronectin modulates the capacity for cell-adhesion. A brain proteoglycan with tyrosine phosphatase activity has been found to exhibit anti-adhesion activity to neuronal cells in the nervous center. This proteoglycan may function as a receptor for pleiotrophin (Noda). Sofue has suggested that laminin may be a IGF-I-dependent differentiation-inducing factor and further found the inbolvement of tyrosine phosphorylation in the signal transduction. Inagaki has succeeded in raising monoclonal antivodies to phosphorylated cytoskeletal proteins and revealed the possible relationship of the phosphorylation of intermediate filaments to the changes in cell-adhesion of proliferating cells. Tsukita has observed the activation of integrin when a cadherin-binding protein, b-catenin is forced to be expressed. The first and second group meetings were held in Nagoya to discuss results, give useful suggestions and comments each other and exchange current informations. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (225 results)

All Other

All Publications (225 results)

  • [Publications] R.Perris,R.et al.: "Inhibitory effects of PG-H/aggrecan and PG-M/versican on avian neural crest cell migration." FASEB J. 10・2. 293-301 (1996)

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  • [Publications] Takanosu,M.et al.: "Distribution of chondroitin sulphate proteoglycans and peanut agglutinin-binding molecules during bovine fetal palatine ridge formation." J Anat. 189. 109-115 (1996)

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  • [Publications] Isogai,Z.et al.: "2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan,PG-M/versican." Cancer Res. 56. 3902-3908 (1996)

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  • [Publications] Yada,T.et al.: "Transient accumulation of perisinusoidal chondroitin sulfate proteoglycans during liver regeneration and development." J Histochem Cytochem. 44・9. 969-980 (1996)

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  • [Publications] Kurita,K.et al.: "Occurrence of PG-Lb,a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian cpiphyseal cartilage : molecular cloning and sequence analysis of the mouse cDNA" Biochem J. 318. 909-914 (1996)

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  • [Publications] 板野直樹、木全弘治: "プロテオグリカンと癌転移" 現代医療. 28・9. 35-39 (1996)

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  • [Publications] 高木秀和、木全弘治: "細胞基質間接着におけるプロテオグリカンの役割" 実験医学. 14・17. 22-28 (1996)

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  • [Publications] K.NAGATA: "HSP47 : a collagen-specific molecular chaperone in the endoplasmic reticulum." TiBS. (Trends in Biochemical Sciences). 21. 23-26 (1996)

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  • [Publications] T.S.H.EL-THAHER et al.: "The pH-dependent,ATP-independent interaction of collagen specific serpin/stress protein HSP47." Prot Pept Lett.3. 1-8 (1996)

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  • [Publications] M.SATOH et al.: "Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen." J. Cell Biol.133. 469-483 (1996)

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  • [Publications] N.KAWADA et al.: "Expression of heat-shock protein 47 in mouse liver." Cell Tissue Res.284. 341-346 (1996)

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  • [Publications] A.NAKAI et al.: "HSF4,a new member of the human heat shock factor gene family which lacks properties of a transcriptional activator." Mol. Cell. Biol.17. 469-481 (1997)

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  • [Publications] K.NAGATA et al.: "Involvement of HSP47 in the folding and processing of procollagen in the ER." Molecular Chaperones in Proteins;. (In press). (1997)

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  • [Publications] Jeon,H.,Ono,M.,Kumagai,C.,Miki.K.,Morita,A.,Kitagawa,Y.: "Pericytes from microvessel fragment produce type IV collagen,entactin/nidogen and multiple laminin isoforms." Biosci. Biotech. Biochem.60. 856-861 (1996)

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  • [Publications] Niimi.T.and Kitagawa,Y.: "Distinct role of mouse laminin β1 long arm domains for α1 β1 γ1 trimer formation." FEBS Letters. 400. 71-74 (1997)

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  • [Publications] Niimi,T.,K.and Kitagawa,Y.: "Expression of the long arm sequence of mouse laminin α1, β1 or γ1 chain COSI cells and assembly of monkey-mouse hybrid laminin." J. Biochem.(In press).

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  • [Publications] Kumagai,C.,Kadowaki,T.and Kitagawa,Y.: "Drosophila laminin assembly formining two types of αβγ trimers in Kc 167 cells" Matrix Biol.(In press).

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  • [Publications] Matsuura,R.et al.: "Deposition of PG-M/versican is a major cause of human coronary restenosis after percutaneous traus luminal coronary angioplasty." J Pathol. 180. 311-316 (1996)

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  • [Publications] Vaidya,P.et al.: "Combined analysis of expression of c-erbB-2,Ki-67 antigen,and tenascin provides better prognostic indicator of carcinoma of the papilla of Vater." Pancreas. 12. 196-201 (1996)

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  • [Publications] Vaidya,P. et al.: "Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma." J Pathol. 178. 140-145 (1996)

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  • [Publications] Tatematsu,M.et al.: "Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN Balb/x chimeric mice treated with 1,2-dimethylhydrazine : Immunohistocemical detection of C3H strain-specifie antigen and simple sequence length polymorphism analysis of DNA." Int J cancer. 66. 234-238 (1996)

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  • [Publications] Watanabe,E.,Kushima,Y.and Oohira,A.: "Heparan sulfate proteoglycan associated with growing parallel fibers of granule cells in the rat cerebellar cortex" Journal of Brain Science. 22. 67-75 (1996)

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  • [Publications] Watanabe,E.,Matsui,F.,Keino,H. et al.: "A membrane-bound heparan sulfate proteoglycan that is transiently expressed on growing axons in the rat brain" Journal of Neuroscience Research. 44. 84-96 (1996)

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  • [Publications] Preobrazhensky,A.A.,Oohira,A.et al.: "Identification of a monoclonal antibody AT5 as a new member of HNK-1 antibody family : The reactivity with myelin---" Neurochemical Research. 22(in press). (1997)

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  • [Publications] Fukuda,T.,Kawano,H.,Ohyama,K.et al.: "Immunohistochemical evidence for molecular interactions implicated in the formation of the thalamocortical ---" Journal of Comparative Neurology. (in press). (1997)

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  • [Publications] 大平 敦彦: "神経回路形成と脳特異プロテオグリカン" 神経研究の進歩. 44. 952-960 (1996)

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  • [Publications] 時田 義人、大平 敦彦: "脳特異プロテオグリカン;ニューログリカンC、ニューロカン、ホスファカン" 蛋白質 核酸 酵素. 42. 567-570 (1997)

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  • [Publications] Akamatsu,H.et al: "Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin." Cancer Research. 56. 4541-4546 (1996)

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  • [Publications] Chen,J.et al: "Distinct structural requirements for interaction of the integrins α5B1,αvB5,and αvB6 with the central cell binding domain in fibronectin." Cell Adhesion and Communication. 4. 237-250 (1996)

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  • [Publications] Murayama,O.et al: "Novel peptide ligands for integrin α6B1 selected from a phage display library." Journal of Biochemistry. 120. 445-451 (1996)

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  • [Publications] Yamamoto,H.et al: "Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin α6 subunit expression." International Journal of Cancer. 65. 519-524 (1996)

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  • [Publications] Hino,K.et al: "Adherence of synovial cells on EDA+fibronectin." Arthritis Rheumatism. 39. 1685-1692 (1996)

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  • [Publications] M.Obara and K.Yoshizato: ""The Gly-Arg-Glu-Ser-Lys-Pro sequence of the fibronectin type III4 repeat is required for the fibroblast-mediated collagen gel contaction."" Mol. Biol. Cell. 7. 63a- (1996)

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  • [Publications] 小原政信・吉里勝利: "コラーゲンマトリックスの機能解析" 医学のあゆみ、医歯薬出版. 177. 13-16 (1996)

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  • [Publications] Itano,N.et al.: "Phosphorylation of a membrane intercalated proteoglycan,syndecan-2,expressed in a shtroma inducing clone from a mouse lung carucinoma." Biochem J. 315. 925-930 (1996)

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  • [Publications] 岡山實 他: "がん転移と細胞接着分子" 現代科学. 308. 51-57 (1996)

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  • [Publications] 草野(水野)由理 他: "細胞外マトリックス受容体シンデカン-2のヘパラン硫酸鎖に含まれるフィブロネクチン結合部位の糖鎖構造" Biotherapy. 10. 1318-1323 (1996)

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  • [Publications] Saga H.et.al.: "Paradoxical expression of α-smooth muscle sctin in visceral and vascular smooth muscle cells in their phenotype-dependent manner." J. Biol. Chem.(in press). (1997)

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  • [Publications] Kashiwada K.et.al.: "Coordinate expression of α-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells." J. Biol. Chem.(in press). (1997)

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  • [Publications] Ando Y.et.al.: "Enhanced golmerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid therapy." J. Clin. Invest.(in press). (1997)

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  • [Publications] Obata H.et.al.: "Smooth muscle cell phenotype-dependent transcriptional regulation of the α1 integrin gene." J. Biol. Chem.(in press). (1997)

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  • [Publications] Sobue K.et.al.: "Phenotype-dependent gene regulation of smooth muscle cell-specific cytoskeletal proteins." Mol. Cell Biochem.(in press). (1997)

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  • [Publications] Hayashi K.et.al.: "IGF-I and laminin-generated signallings are essential for maintaining a differentiated phenotype of smooth muscle cells." J. Biol. Chem.(in press). (1997)

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  • [Publications] Inagaki,M.et.al.: "Dynamic property of intermediate filaments : Regulation by phosphorylation." BioEssays.18. 481-487 (1996)

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  • [Publications] Takai,Y.et.al.: "Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes." J. Cell Biol.133. 141-149 (1996)

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  • [Publications] Sekimata,M.et.al.: "Detection of protein kinase activity specifically activated at metaphase-anaphase transition." J. Cell Biol.132. 635-641 (1996)

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  • [Publications] Maeda,et al.: "6B4 proteoglycan/phosphacan,an extracellular variant of receptor-like protein-tyrosine phosphatase ζ/RPTPβ,binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)" Journal of Biological Chemistry. 271・35. 21446-21452 (1996)

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  • [Publications] Furuse,M.,Fujimoto,K.,Sato,N.,Hirase,T.,Tsukita,Sa.,and Tsukita,Sh.: "Overexpression of occludin,a tight junction-associated integral membrane protein,induces the formation of intracellular multilamellar bodies bearing tight junction-like structure." Journal of Cell Science. 109. 429-435 (1996)

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  • [Publications] Tokai,N.,Fujimoto-Nishiyama,A.,Toyoshima,Y.,Yonemura,S.,Tsukita,Sh.,Inoue,I.,and Yomamoto,T.: "Kid,a novel kinesin-like DNA binding protein,is localized to chromosomes and the mitotic spindle" EMBO Journal. 15. 457-467 (1996)

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  • [Publications] Hirase,T.,Furuse,M.,and Tsukita,Sh.: "A155kDa undercoat-constitutive protein of cell-to-call adherens junctions" European Journal of Cell Biology. (in press). (1996)

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  • [Publications] Ando-Akatsuka,Y.,Saitou,M.,Hirase,T.,Kishi,M. Sakakibara,A.,Itoh,M.,Yonemura,S.,Furuse,M.,Tsukita,Sh.: "Interspecies diversity of the oculdin sequence : cDNA cloning of human,mouse,dog and rat-kangaroo homologues" Journal of Cell Biology. 133. 43-47 (1996)

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  • [Publications] Hirano,M.,Sato,N.,Kondo,T.,Yonemura,S.,Monden,M.,Sasaki,T.,Takai,Y.,Tsukita,Sh.,and Tsukita,Sa.: "Regulation mechanism of ERM (EZRIN/Radixin/Moesin) Protein/Plasma Membrane Association : Possible Involvement of Phosphatidylinositol Turnover and Rho-dependent Signaling Pathway" Journal of Cell Biology. 135. 1-16 (1996)

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  • [Publications] MacCarthy,K.M.,Skare,I.B.,Stankewich,M.C.,Furuse,M.,Tsukita,Sh.,Rogers,R.A.,Lynch,R.D.,and Schneeberger,E.E.: "Occuldin id a functional component of the tight junction." Journal of Cell Science. 109. 2287-2298 (1996)

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  • [Publications] Ito,K.et al.: "Multiple forms of mouse PG-M,a large chondroitin sufate proteoglycan generated by alternative splicing" The Journal of Biological Chemistry. 270. 958-965 (1995)

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  • [Publications] Zako,M.et al.: "Expression of PG-M (V3),an alternatively spliced from of PG-M without a chondroitin sulfate attachement region in mouse and human tissue." The Journal of Biological Chemistry. 270. 3914-3918 (1995)

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  • [Publications] Shinomura,T.et al.: "The gene structure and organization for mouse PG-M,a large chondroitin sulfate proteoglycan : Genomic background for the generation of mulitiple PG-M transcripts" The Journal of Biological Chemistry. 270. 10328-10333 (1995)

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  • [Publications] Kato,S.et.al.: "Chondroitin sulfate immobilized onto culture substrates modulates 6DNA synthesis,tyrosine aminotransferase induction,and intercellular communication in primary rat hepatocytes" Cell Structure and function. 20. 199-209 (1995)

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  • [Publications] Fukuoka,M.et al.: "Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase" The Journal of Biological Chemistry. 270. 18575-18580 (1995)

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  • [Publications] Nagai,N.et al.: "Quercetin suppresses heat shock response by down regulation of HSP1" Biochemical and Biophysical Research Communications. 208. 1099-1105 (1995)

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  • [Publications] Higashi,T.et al.: "Activation of heat shock factor 1 in rat brain during cerebral ischemia of after heat shock" Mol. Brain Res.34. 262-270 (1995)

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  • [Publications] Nakai,A.et al.: "The DNA-Binding properties of two heat shock factors, HSP1 and HSP3,are induced in the avian erythroblast cell line HD6" Molecular and Cellular Biology. 15. 5268-5278 (1995)

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  • [Publications] Yasuda,K.et al.: "Cloning and expression of murine high-molecular-weight heat shock proteins,HSP105" The Journal of Biological Chemistry. 270. 29718-29723 (1995)

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  • [Publications] Watanabe,E.et al.: "Distribution of brain-specific proteoglycan,neurocan,and the correspondion mRNA during the formation of barrels in the rat" European Journal of Neuroscience. 7. 547-554 (1995)

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  • [Publications] Katoh-Semba,R.et al.: "Chondroitin sulfate proteoglycan in the rat brain : Candidates for axon barriers of sensory neurons and the possible..." Nerosci. Let.189. 25-28 (1995)

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    • Related Report
      1996 Final Research Report Summary
  • [Publications] Maeda,N.et al.: "Purfication,characterization and developmental expression of brain-specific chondroitin sulfate..." Neurosci.67. 23-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Watanabe,E.et al.: "Neuroglycan C,a novel membrane-spanning chondroitin sulfate proteoglycan taht is restricted to the brain" Journal of Biological Chemistry. 270. 26876-26882 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大平 敦彦: "神経回路網形成期の脳に発現しているプロテオグリカンの構造と機能" 日本神経精神薬理学雑誌. 171-176 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mizutani,H.et al.: "Nodular scleroderma : Focally increased tenascin expression differing from that in the surrounding scleroderma soin" J. Dermatology. 22. 267-271 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ishihara,A.et al.: "Tenascin expressuin in cancer cells amd stroma of human breast cancer and its prognostic significance" Clin. Cancer Res.1. 1035-1041 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshida,T.et al.: "Tenascin expression in breast cancer cell : A maker for poor grognosis in breast cancer" Cancer Letter. 90. 65-73 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ichihara-Tanaka,K.et al.: "Role of the carboxyl-terminal Fib2 domain in fibronectin matrix assembly" Journal of Cell Science. 108. 907-915 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Healy J.M.et al.: "Peptide ligands for integrin αvβ3 selected from random phage display libraries" Biochemistry. 34. 3948-3955 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ohashi,H.et al.: "Up-regulation of integrin α5β1 expression by interleukin-6 in rabbit corneal epithelial cells" Experimental Cell Research. 218. 418-423 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Obara,M.et al.: "Possible involvement of the α5 subunit of α5β1 integrin with the synergistic region of the central cell-binding domain of fibronectin in cells to fibronectin binding" Exp. Cell Res.216. 273-276 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 坂倉照好・小原政信: "細胞外マトリックスの接着および反接着作用" 医学のあゆみ. 174. 32-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yano,H.et al.: "Transcriptional regulation of the chicken caldesmon gene : activation of gizzard type caldsmon promoter a CArG box-like motif" Journal of Biological Chemistry. 270. 23661-23666 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshida,K.et al.: "Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin (Non-erythroid spectrin or fodrin) by calpain." Circulation Res.77. 603-610 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ilic D.et al.: "Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-dedicient mice." Nature. 377. 539-544 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ozawa,K.et al.: "Translocation of cortactin (p80/85) to the actin-based cytoskeleton during thrombin receptor-mediated platelet activation" Exp. Cell Res.221. 197-204 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogawara,et al.: "Differential targeting of protein kinase C and CaM kinase II signalings to vimentin" Journal of Cell Biology. 109. -1066 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kumagai,N.et al.: "Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts possible involvement in rho p21-mediated signaling" FEBS. Lett.366. 11- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saito Y.et al.: "Identification of Glu^<173> as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme." FEBS. Lett.371. 105- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seckl M.J.,et al.: "Guanosine 5'-3-O-(Thio) triphosphate stimulates tyrosine phosphorylation of p125^<FAK> and paxillin in permeabilized Swiss 3T3 cells" Journal of Biological Chemistry. 270. 6984-6990 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Madalue,P.et al.: "A novel partner for the GTP-bound forms of rho and rac" FEBS. Lett.377. 243-248 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Maeda,N.et al.: "Purification,characterization and developmental expression of a brain-specific chondroitin sulfate proteoglycan,6B4 proteoglycan/phosphacan" Neuroscience. 67. 23-35 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Maeda,N.et al.: "6B4 proteoglycan/phosphacan is a repulsive substrate but promotes morphological differentiation of cortical neurons" Development. 122. 647-658 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takeda,H.et al.: "V-src kinase shifts the cadherin based cell adhesion from the strong to the weak state and β-catenin is not required for the shift" Journal of Cell Biology. 131. 1839-1847 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 木全弘治: "細胞外マトリックス 概論(分担)" 実験医学別冊 用語ライブラリー細胞接着 羊土社, 28-31 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉浦信夫、木全弘治: "GAG-脂質誘導体を用いた細胞接着阻害実験(分担)" 細胞工学別冊 実験プロトコールシリーズ グライコバイオロジー実験プロコトール-糖タンパク質・糖脂質・プロテオグリカン-秀潤社, 268-272 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大平 敦彦他: "Bio Science用語ライブラリー「細胞接着」(分担)" 羊土社「実験医学別冊」(宮坂昌之、矢原一郎編), 205-43-51 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大平 敦彦、松井 ふみ子: "グリコバイオロジー実験プロトコール(分担)" 秀潤社「細胞工学別冊」(谷口、鈴木、古川、菅原監修), 382(86 305) (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡山實 他: "細胞外マトリックス-臨床医学への応用-(分担執筆:シグナル伝達)" 渡邊明治・岡崎勲編、メディカルレビュー社, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 小栗佳代子 他: "グライコバイオロジー実験プロトコール(分担執筆:セルロースアセテート膜電気泳動によるGACの同定)" 谷口直之・鈴木明身・古川清・菅原一幸編、秀潤社, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡山實 他: "グライコバイオロジー実験プロトコール(分担執筆:β-D-キシロシドを用いたGAG糖鎖の生合成実験法)" 谷口直之・鈴木明身・古川清・菅原一幸編、秀潤社, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Perris, R.et al.: "Inhibitory effects of PG-M/aggrecan and PG-M/versican on avian neural crest cell migration." FASEB J. 10.2. 293-301 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Isogai, Z.et al.: "2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican." Cancer Res. 56. 3902-3908 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nagata, N.et al.: "HSP47 : a collagen-specific molecular chaperone in the endoplasmic reticulum." TiBS. 21. 23-26 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoh, M.et al.: "Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen." J Cell Biol. 133. 469-483 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Niimi, T.et al.: "Distinct role of mouse laminin beta1 long arm domains for alpha1 beta1gamma trimaer formation." FEBS Letters. 400. 71-74 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kumagai, C.et al.: "Drosophila laminin assembly formining two types of alphabetagamma trimers in Kc 167 cells." Matrix Biol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mizutani, H.et al.: "Nodular sclerderma : Focally increased tenascin expression differing from that in the surrounding scleroderma soin." J Dermatology. 22. 267-271 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshida, T.et al.: "Tenascin expression in breast cancer cell : A maker for poor grognosis in breast cancer." Cancer Letter. 90. 65-73 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Watanabe, E.et al.: "Neuroglycan C,a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain." J Biol Chem. 270. 26876-26882 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Watanabe, E.et al.: "A membrane-bound heparan sulfate proteoglycan that is transiently expressed on growing axons in the rat brain." J Neuroscience Research. 44. 84-96 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ichihara-Tanaka, K.et al.: "Role of the carboxyl-terminal Fib2 domain in fibronectin matrix assembly" J of Cell Science. 108. 907-915 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Chen, J.et al.: "Distinct structural requirements for interaction of the integrins alpha5beta1, alphavbeta5, and alphavbeta6 with the central cell binding domain in fibronectin." Cell Adhesion and Communication. 4. 237-250 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Obara, M.et al.: "Possible involvement of the alpha5 subunit of alpha5beta1 integrin with the synergitic region og the central cell-binding domain of fibronectin in cells to fibronectin binding." Exp Cell Res. 216. 273-276 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Obara, M.et al.: "The Gly-Arg-Glu-Der-Lys Pro sequence of the fibronectin type III4 repear is required fpr the fibroblast-mediated collagen gel contation." Mol Biol Cell. 7. 63a (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Itano, N.et al.: "Phosphorylation of a membrane intercalated proteoglycan, syndecan-2, expressed in a shtroma inducing clone from a mouse lung carucinoma" Biochem J. 315. 925-930 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yano, H.et al.: "Transcriptional regulation of the chiken caldesmon gene : activation of gizzard type caldesmon promoter a CArG box-like motif." J.Biol Chem. 270. 23661-23666 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ilic, D.et al.: "Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-dedicient mice." Nature. 377. 539-544 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogawara, et al.: "Differential targeting of protein kinase C and CaM kinase II signalings to vimentin." J Cell Biol. 109. 1066 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takai, Y et al.: "Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes." J Cell Biol. 133. 141-149 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Maeda, N.et al.: "6B4 proteoglycan/phosphacan is a repulsive substrate but promotes morphological differentiation of cortical neurons." Development. 122. 647-658 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Maeda, N.et al.: "6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrisune phosphatase zetaRPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)" J Biol Chem. 271.35. 21446-21452 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takeda, H.et al.: "V-src kinase shifts the cadherin based cell adhesion from the strong to the weak astate and beta-catenin is not required for the shift." J Cell Biol. 131. 1839-1847 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirao, M.et al.: "Regulation mechanism of ERM (EZRIN/Radixin/Moesin) protein/plasma membrane association : possible involvement of phosphatidylinositol turnover and rhodependent signaling pathway." J Cell Biol. 135. 1-16 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Seckl M.J., et al.: "Guanosine 5'-3-O-(thio) triphosphate stimulates tyrosine phosphorylation of p125^<FAK> and paxillin in permeabilized Swiss 3T3 cells." J Biol Chem. 270. 6984-6990 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] R.Perris,R.et al.: "Inhibitory effects of PG-H/aggrecan and PG-M/versican on avian neural crest cell migration." FASEB J. 10・2. 293-301 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takanosu,M.et al.: "Distribution of chondroitin sulphate proteoglycans and peanut agglutinin-binding molecules during bovine fetal palatine ridge formation." J Anat. 189. 109-115 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Isogai,Z.et al.: "2Bl antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican." Cancer Res. 56. 3902-3908 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yada,T.et al.: "Transient accumulation of perisinusoidal chondroitin sulfate proteoglycans during liver regeneration and development." J Histochem Cytochem. 44・9. 969-980 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kurita,K.et al.: "Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage : molecular cloning and sequence analysis of the mouse cDNA." Biochem J. 318. 909-914 (1996)

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      1996 Annual Research Report
  • [Publications] 板野直樹、木全弘治: "プロテオグリカンと癌転移" 現代医療. 28・9. 35-39 (1996)

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      1996 Annual Research Report
  • [Publications] 高木秀和、木全弘治: "細胞基質間接着におけるプロテオグリカンの役割" 実験医学. 14・17. 22-28 (1996)

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      1996 Annual Research Report
  • [Publications] K.NAGATA: "HSP47 : a collagen-specific molecular chaperone in the endoplasmic reticulum." TiBS. (Trends in Biochemical Sciences). 21. 23-26 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kumagai,C.,Kadowaki,T.and Kitagawa,Y.: "Drosophila laminin assembly formining two types of αβγtrimers in Kc 167 cells" Matrix Biol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsuura,R.etal.: "Deposition of PG-M/versican is a major cause of human coronary restenosis after percutaneous traus luminal coronary angioplasty." J Pathol. 180. 311-316 (1996)

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      1996 Annual Research Report
  • [Publications] Vaidya,P.et al.: "Combined analysis of expression of c-erbB-2, Ki-67 antigen, and tenascin provides better prognostic indicator of carcinoma of the papilla of Vater." Pancreas. 12. 196-201 (1996)

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      1996 Annual Research Report
  • [Publications] Vaidya,P.et al.: "Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma." J Pathol. 178. 140-145 (1996)

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      1996 Annual Research Report
  • [Publications] Tatematsu,M.et al.: "Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN Balb/x chimeric mice treated with 1.2-dimethylhydrazine : Immunohistocemical detection of C3H strain-specifie antigen and simple sequence length polymorphism analysis of DNA." Int J cancer. 66. 234-238 (1996)

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      1996 Annual Research Report
  • [Publications] Watanabe,E.,Kushima,Y.and Oohira,A.: "Heparan sulfate proteoglycan associated with growing parallel fibers of granule cells in the rat cerebellar cortex" Journal of Brain Science. 22. 67-75 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Watanabe,E.,Matsui,F.,Keino,H.et al.: "A membrane-bound heparan sulfate proteoglycan that is transiently expressed on growing axons in the rat brain" Journal of Neuroscience Research. 44. 84-96 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Preobrazhensky,A.A.,Oohira,A.et al.: "Identification of a monoclonal antibody AT5 as a new member of HNK-1 antibody family : The reactivity with myelin---" Neurochemical Research. 22(in press). (1997)

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      1996 Annual Research Report
  • [Publications] T.S.H.EL-THAHER et al.: "The pH-dependent, ATP-independent interaction of collagen specific serpin/stress protein HSP47." Prot Pept Lett.3. 1-8 (1996)

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      1996 Annual Research Report
  • [Publications] M.SATOH et al.: "Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen." J. Cell Biol.133. 469-483 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.KAWADA et al.: "Expression of heat-shock protein 47 in mouse liver." Cell Tissue Res.284. 341-346 (1996)

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      1996 Annual Research Report
  • [Publications] A.NAKAI et al.: "HSF4, a new member of the human heat shock factor gene family which lacks properties of a transcriptional activator." Mol. Cell. Biol.17. 469-481 (1997)

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      1996 Annual Research Report
  • [Publications] K.NAGATA et al.: "Involvement of HSP47 in the folding and processing of procollagen in the ER." Molecular Chaperones in Proteins;. (In press). (1997)

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      1996 Annual Research Report
  • [Publications] Jeon,H.,Ono,M.,Kumagai,C.,Miki,K.,Morita,A.,Kitagawa,Y.: "Pericytes from microvessel fragment produce type IV collagen, entactin/nidogen and multiple laminin isoforms." Biosci. Biotech. Biochem.60. 856-861 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Niimi.T.and Kitagawa,Y.: "Distinct role of mouse laminin β1 long arm domains for α1β1γ1 trimer formation." FEBS Letters. 400. 71-74 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Niimi,T.,Miki,K.and Kitagawa,Y.: "Expression of the long arm sequence of mouse laminin α1, β1 or γ1 chain in COSI cells and assembly of monkey-mouse hybrid laminin." J. Biochem.(In press).

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      1996 Annual Research Report
  • [Publications] Fukuda,T.,Kawano,H.,Ohyama,K. et al.: "Immunohistochemical evidence for molecular interactions implicated in the formation of the thalamocortical---" Journal of Comparative Neurology. (in press). (1997)

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      1996 Annual Research Report
  • [Publications] 大平敦彦: "神経回路形成と脳特異プロテオグリカン" 神経研究の進歩. 44. 952-960 (1996)

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      1996 Annual Research Report
  • [Publications] 時田義人、大平敦彦: "脳特異プロテオグリカン;ニューログリカンC、ニューロカン、ホスファカン" 蛋白質 核酸 酵素. 42. 567-570 (1997)

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      1996 Annual Research Report
  • [Publications] Akamatsu,H.et al: "Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin." Cancer Research. 56. 4541-4546 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Chen,J.et al: "Distinct structural requirements for interaction of the integrins α5β1, αvβ5, and αvβ6 with the central cell binding domain in fibronectin." Cell Adhesion and Communication. 4. 237-250 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Murayama,O.et al: "Novel peptide ligands for integrin α6β1 selected from a phage display library." Journal of Biochemistry. 120. 445-451 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto,H.et al: "Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin α6 subunit expression." International Journal of Cancer. 65. 519-524 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hino,K.et al: "Adherence of synovial cells on EDA+fibronectin." Arthritis Rheumatism. 39. 1685-1692 (1996)

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      1996 Annual Research Report
  • [Publications] M.Obara and K.Yoshizato: ""The Gly-Arg-Glu-Ser-Lys-Prosequence of the fibronectin type III4 repeat is required for the fibroblast-mediated collagen gel contaction."" Mol. Biol. Cell. 7. 63a- (1996)

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      1996 Annual Research Report
  • [Publications] 小原政信・吉里勝利: "コラーゲンマトリックスの機能解析" 医学のあゆみ、医歯薬出版. 177. 13-16 (1996)

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      1996 Annual Research Report
  • [Publications] Itano,N.et al.: "Phosphorylation of a membrane intercalated proteoglycan, syndecan-2, expressed in a shtroma inducing clone from a mouse lung carucinoma." Biochem J. 315. 925-930 (1996)

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      1996 Annual Research Report
  • [Publications] 岡山實他: "がん転移と細胞接着分子" 現代科学. 308. 51-57 (1996)

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      1996 Annual Research Report
  • [Publications] 草野(水野)由理他: "細胞外マトリックス受容体シンデカン-2のヘパラン硫酸鎖に含まれるフィブロネクチン結合部位の糖鎖構造" Biotherapy. 10. 1318-1323 (1996)

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      1996 Annual Research Report
  • [Publications] Saga H.et.al.: "Paradoxical expression of α-smooth muscle actin in visceral and vascular smooth muscle cells in their phenotype-dependent manner." J. Biol. Chem.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Kashiwada K.et.al.: "Coordinate expression of α-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells." J. Biol. Chem.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Ando Y.et.al.: "Enhanced golmerular expression of caldesmon in IgA nephropathy and its suppression by glucocorticoid therapy." J. Clin. Invest.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Obata H.et.al.: "Smooth muscle cell phenotype-dependent transcriptional regulation of the α1 integrin gene." J. Biol. Chem.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Sobue K.et.al.: "Phenotype-dependent gene regulation of smooth muscle cell-specific cytoskeletal proteins." Mol. Cell Biochem.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Hayashi K.et.al.: "IGF-I and laminin-generated signallings are essential for maintaining a differentiated phenotype of smooth muscle cells." J. Biol. Chem.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Inagaki,M.et al.: "Dynamic property of intermediate filaments : Regulation by phosphorylation." Bio Essays.18. 481-487 (1996)

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      1996 Annual Research Report
  • [Publications] Takai,Y.et al.: "Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes." J. Cell Biol.133. 141-149 (1996)

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      1996 Annual Research Report
  • [Publications] Sekimata,M.et al.: "Detection of protein kinase activity specifically activated at metaphase-anaphase transition." J. Cell Biol.132. 635-641 (1996)

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      1996 Annual Research Report
  • [Publications] Maeda,et al.: "6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase ζ/RPTPβ, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)" Journal of Biological Chemistry. 271・35. 21446-21452 (1996)

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      1996 Annual Research Report
  • [Publications] Furuse,M.,Fujimoto,K.,Sato,N.,Hirase,T.,Tsukita,Sa.,and Tsukita,Sh.: "Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures." Journal of Cell Science. 109. 429-435 (1996)

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      1996 Annual Research Report
  • [Publications] Tokai,N.,Fujimoto-Nishiyama,A.,Toyoshima,Y.,Yonemura,S.,Tsukita,Sh.,Inoue.J.,and Yomamoto,T.: "Kid,a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle" EMBO Journal. 15. 457-467 (1996)

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      1996 Annual Research Report
  • [Publications] Hirase,T.,Furuse,M.,and Tsukita,Sh.: "A155kDa undercoat-constitutive protein of cell-to-call adherens junctions" European Journal of Cell Biology. (in press). (1996)

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      1996 Annual Research Report
  • [Publications] Ando-Akatsuka,Y.,Saitou,M.,Hirase,T.,Kishi,M.Sakakibara,A.,Itoh,M.,Yonemura,S.,Furuse,M.,Tsukita,Sh.: "Interspecies diversity of the occuldin sequence : cDNA cloning of human, mouse, dog and rat-kangaroo homologues" Journal of Cell Biology. 133. 43-47 (1996)

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      1996 Annual Research Report
  • [Publications] Hirao,M.,Sato,N.,Kondo,T.,Yonemura,S.,Monden,M.,Sasaki,T.,Takai,Y.,Tsukita,Sh.and Tsukita,Sa.: "Regulation mechanism of ERM (EZRIN/Radixin/Moesin) Protein/Plasma Membrane Association : Possible Involvement of Phosphatidylinositol Turnover and Rho-dependent Signaling Pathway" Journal of Cell Biology. 135. 1-16 (1996)

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      1996 Annual Research Report
  • [Publications] MacCarthy,K.M.,Skare,I.B.,Stankewich M.C.Furuse,M.,Tsukita,Sh.,Rogers,R.A.,Lynch.R.D.,and Schneeberger,E.E.: "Occuldin is a functional component of the tight junction." Journal of Cell Science. 109. 2287-2298 (1996)

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      1996 Annual Research Report
  • [Publications] 木全弘治: "細胞外マトリックス 概論(分担、pp.28-31)" 実験医学別冊 用語ライブラリー細胞接着 羊土社, (1996)

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      1996 Annual Research Report
  • [Publications] 杉浦信夫、木全弘治: "GAG-脂質誘導体を用いた細胞接着阻害実験(分担、pp.268-272)" 細胞工学別冊 実験プロトコールシリーズ グライコバイオロジー実験プロトコール-糖タンパク質・糖脂質・プロテオグリカン-秀潤社, (1996)

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      1996 Annual Research Report
  • [Publications] 大平敦彦他: "Bio Science用語ライブラリー「細胞接着」(分担、pp.43-51)" 羊土社「実験医学別冊」(宮坂昌之、矢原一郎編), 205 (1996)

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      1996 Annual Research Report
  • [Publications] 大平敦彦、松井ふみ子: "グリコバイオロジー実験プロトコール(分担、pp.86,pp.305)" 秀潤社「細胞工学別冊」(谷口、鈴木、古川、菅原監修), 382 (1996)

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      1996 Annual Research Report
  • [Publications] 岡山實他: "細胞外マトリックス-臨床医学への応用-(分担執筆:シグナル伝達)" 渡邊明治・岡崎勲編、メディカルレビュー社, (1996)

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      1996 Annual Research Report
  • [Publications] 小栗佳代子他: "グライコバイオロジー実験プロトコール(分担執筆:セルロース アセテート膜電気泳動によるGAGの同定)" 谷口直之・鈴木明身・古川清・菅原一幸編、秀潤社, (1996)

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      1996 Annual Research Report
  • [Publications] 岡山實他: "グライコバイオロジー実験プロトコール(分担執筆:β-D-キシロシドを用いたGAG糖鎖の生合成実験法)" 谷口直之・鈴木明身・古川清・菅原一幸編、秀潤社, (1996)

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      1996 Annual Research Report
  • [Publications] Ito, K. et al.: "Multiple forms of mouse PG-M, a large chondroitin sufate proteoglycan generated by alternative splicing" The Journal of Biological Chemistry. 270. 958-965 (1995)

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      1995 Annual Research Report
  • [Publications] Zako, M. et al.: "Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment region in mouse and human tissue." The Journal of Biological Chemistry. 270. 3914-3918 (1995)

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      1995 Annual Research Report
  • [Publications] Shinomura, T. et al.: "The gene structure and organization for mouse PG-M, a large chondroitin sulfate proteoglycan: Genomic background for the generation of multiple PG-M transcripts" The Journal of Biological Chemistry. 270. 10328-10333 (1995)

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      1995 Annual Research Report
  • [Publications] Kato, S. et. al.: "Chondroitin sulfate immobilized onto culture substrates modulates 6DNA synthesis, tyrosine aminotransferase induction, and intercellular communication in primary rat hepatocytes" Cell Structure and function. 20. 199-209 (1995)

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      1995 Annual Research Report
  • [Publications] Fukuoka, M. et al.: "Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase" The Journal of Biological Chemistry. 270. 18575-18580 (1995)

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      1995 Annual Research Report
  • [Publications] Nagai, N. et al.: "Quercetin suppresses heat shock response by down regulation of HSP1" Biochemical and Biophysical Research Communications. 208. 1099-1105 (1995)

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      1995 Annual Research Report
  • [Publications] Higashi, T. et al.: "Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock" Mol. Brain Res.34. 262-270 (1995)

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      1995 Annual Research Report
  • [Publications] Nakai A. et al.: "The DNA-Binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6" Molecular and Cellular Biology. 15. 5268-5278 (1995)

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      1995 Annual Research Report
  • [Publications] Yasuda, K. et al.: "Cloning and expression of murine high-molecular-weight heat shock proteins, HSP105" The Journal of Biological Chemistry. 270. 29718-29723 (1995)

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      1995 Annual Research Report
  • [Publications] Nagata, K. et al.: "HSP47: a collagen-specific molecular chaperone in the endoplasmic reticulum" Trends in Biochemical Sciences. 21. 23-26 (1996)

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      1995 Annual Research Report
  • [Publications] Satoh, M. et al.: "Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen" The Journal of Cell Biology. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Jeon, H. et al.: "Pericytes from microvessel fragment produce type IV collagen and multiple laminin isoforms" Biosci. Biotech. Biochem.(in press). (1995)

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      1995 Annual Research Report
  • [Publications] Kumagai, C. et al.: "Laminin α3-antiserum recognizes α chain in laminin 5 (kalinnin) but not that in laminin 6 (K-laminin) of human keratinocytes" Biochim. Biophys. Acta. (in press). (1995)

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      1995 Annual Research Report
  • [Publications] Watanabe, E. et al.: "Distribution of brain-specific proteoglycan, neurocan, and the correspondion mRNA during the formation of barrels in the rat" European Journal of Neuroscience. 7. 547-554 (1995)

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      1995 Annual Research Report
  • [Publications] Katoh-Semba, R. et al.: "Chondroitin sulfate proteoglycan in the rat brain: Candidates for axon barriers of sensory neurons and the possible" Nerosci. Let.189. 25-28 (1995)

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      1995 Annual Research Report
  • [Publications] Maeda, N. et al.: "Purfication, characterization and developmental expression of brain-specific chondroitin sulfate-" Neurosci.67. 23-35 (1995)

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      1995 Annual Research Report
  • [Publications] Watanabe, E. et al.: "Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain" Journal of Biological Chemistry. 270. 26876-26882 (1995)

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      1995 Annual Research Report
  • [Publications] 大平 敦彦: "神経回路網形成期の脳に発現しているプロテオグリカンの構造と機能" 日本神経精神薬理学雑誌. 171-176 (1995)

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      1995 Annual Research Report
  • [Publications] Mizutani, H. et al.: "Nodular scleroderma: Focally increased tenascin expession differing from that in the surrounding scleroderma soin" J. Dermatology. 22. 267-271 (1995)

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      1995 Annual Research Report
  • [Publications] Ishihara, A. et al.: "Tenascin expressuin in cancer cells and stroma of human breast cancer amd its prognostic significance" Clin. Cancer Res.1. 1035-1041 (1995)

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      1995 Annual Research Report
  • [Publications] Yoshida, T. et al.: "Tenascin expression in breast cancer cell: A maker for poor grognosis in breast cancer" Cancer Letter. 90. 65-73 (1995)

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      1995 Annual Research Report
  • [Publications] Ichihara-Tanaka, K. et al.: "Role of the carboxyl-terminal Fib2 domain in fibronectin matrix assembly" Journal of Cell Science. 108. 907-915 (1995)

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      1995 Annual Research Report
  • [Publications] Healy J. M. et al.: "Peptide ligands for integrin αvβ3 selected from random phage display libraries" Biochemistry. 34. 3948-3955 (1995)

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      1995 Annual Research Report
  • [Publications] Ohashi, H. et al.: "Up-regulation of integrin α5β1 expression by interleukin-6 in rabbit corneal epithelial cells" Experimental Cell Research. 218. 418-423 (1995)

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      1995 Annual Research Report
  • [Publications] Yamamoto, H. et al.: "A←brogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin α6 subunit expression" International Journal of Cancer. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Obara, M. et al.: "Possible involvement of the α5 subunit of α5β1 integrin with the synergistic region of the central cell-binding domain of fibronectin in cells to fibronectin binding." Exp. Cell Res.216. 273-276 (1995)

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      1995 Annual Research Report
  • [Publications] 坂倉照よ・小原政信: "細胞外マトリックスの接着および反接着作用" 医学のあゆみ. 174. 32-35 (1995)

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      1995 Annual Research Report
  • [Publications] Itano, N. et al.: "Phosphorylation of membrane-intercalated proteoglycan, syndecan-2, expressed in a stroma-inducing clone frome a mouse Lewis lung carcinoma" Biochemical Journal. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Yano, H. et al.: "Transcriptional regulation of the chicken caldesmon gene: activation of gizzard type caldesmon promoter a CArG box-like motif" Journal of Biological Chemistry. 270. 23661-23666 (1995)

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      1995 Annual Research Report
  • [Publications] Yoshida, K. et al.: "Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin (Non-erythroid spectrin or fodrin) by calpain." Circulation Res.77. 603-610 (1995)

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      1995 Annual Research Report
  • [Publications] Ilic D. et al.: "Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-dedicient mice." Nature. 377. 539-544 (1995)

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      1995 Annual Research Report
  • [Publications] Ozawa, K. et al.: "Translocation of cortactin (p80/85) to the actin-based cytoskeleton during thrombin receptor-mediated platelet activation" Exp. Cell Res.221. 197-204 (1995)

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      1995 Annual Research Report
  • [Publications] Ozawa, K. et al.: "Phase specific association of heterotrimeric GTP binding proteins with the actin-based cytoskeleton during thrombin receptor-mediated platelet activation" FEBS Lett.(in press). (1996)

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      1995 Annual Research Report
  • [Publications] Saga, H. et al.: "Paradoxical expression of α-smooth muscle cells with their phenotype-dependent manner" EMBO J.(in press). (1996)

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      1995 Annual Research Report
  • [Publications] Ogawara, et al.: "Differential targeting of protein kinase C and CaM kinase II signalings to vimentin" Journal of Cell Biology. 109. 1066 (1995)

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      1995 Annual Research Report
  • [Publications] Sekimata, et al.: "Detection of protein kinase activity specifically activated at metaphase-anaphase transition" Journal of Cell Biology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takai, et al.: "Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes." Journal of Cell Biology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kumagai, N. et al.: "Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts possible involvement in rho p21- mediated signalling." FEBS. Lett.366. 11 (1995)

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      1995 Annual Research Report
  • [Publications] Saito Y. et al.: "Identification of Glu^<173> as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzme." FEBS. Lett.371. 105 (1995)

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      1995 Annual Research Report
  • [Publications] Seckl M. J., et al.: "Guanosine 5'-3-O-(Thio) triphosphate stimulates tyrosine phosphorylation of p125^<FAK> and paxillin in permeabilized Swiss 3T3 cells" Journal of Biological Chemistry. 270. 6984-6990 (1995)

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      1995 Annual Research Report
  • [Publications] Madalue, P. et al.: "A←novel partner for the GTP-bound forms of rho and rac" FEBS. Lett.377. 243-248 (1995)

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      1995 Annual Research Report
  • [Publications] Watanabe, G. et al.: "Protein Kinase, PKN, and PKN-Related protein, rhophilin, as targets of small GTPasse rho" Science. (in press). (1995)

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      1995 Annual Research Report
  • [Publications] Ishizaki, T. et al.: "The small GTP-binding protein rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase" EMBO.Journal. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Maeda, N. et al.: "Purification, characterization and developmental expression of a brain-specific chondroitin sulfate proteoglycan, 6B4 proteoglycan/phosphacan" Neuroscience. 67. 23-35 (1995)

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      1995 Annual Research Report
  • [Publications] Maeda, N. et al.: "6B4 proteoglycan/phosphacan is a repulsive substrate but promotes morphological differentiation of cortical neurons" Development. 122. 647-658 (1995)

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      1995 Annual Research Report
  • [Publications] Takeda, H. et al.: "V-src kinase shifts the cadherin based cell adhesion from the strong to the weak state and β-catenin is not required for the shift" Journal of Cell Biology. 131. 1839-1847 (1995)

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      1995 Annual Research Report
  • [Publications] Ando Akatuka, Y. et al.: "Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog and rat-kangaroo homologues" Journal of Cell Biology. (in press). (1996)

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      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2021-08-23  

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