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Estimation of dietary allowance of magnesium and trace alements using stable isotopes

Research Project

Project/Area Number 07407012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOKAWA Yoshinori  KYOTO UNIVERSITY,Graduate School of Medicine, Professor, 医学研究科, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) HATSUDA Naoki  KYOTO UNIVERSITY,Graduate School of Medicine, Instructor, 医学研究科, 助手 (80283620)
KIMURA Mieko  KYOTO UNIVERSITY,Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60025658)
EZASHI Takatoshi  National Institute of Health and Nutrition, Head, 栄養研究所, 部長 (80191922)
YOKOI Katsuhiko  KYOTO UNIVERSITY,Graduate School of Medicine, Instructor, 医学研究科, 助手 (10200883)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥33,100,000 (Direct Cost: ¥33,100,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥31,700,000 (Direct Cost: ¥31,700,000)
Keywordsdietary allowance of magnesium / zinc deficienty / stable isotope / plasma zinc disappearance / serum ferritin concentration / cluster analysis / ICP mass spectroscopy / plasma zinc concentration / 亜鉛栄養 / 誘導結合プラスマ質量分析法 / 早期交換性亜鉛プール / 血漿亜鉛代謝回転速度 / 除脂肪体重 / 亜鉛排泄量
Research Abstract

Aim of this research is to clarify the dietary allowance of magnesium and trace elements using stable isotopes as this method is very sensitive to detect marginal deficiency status of minerals. However, unfortunately, stable isotope of magnesium did not available within a definite period of time, we investigated dietary allowance of magnesiumusing atomic absorption spectrophotometer. A study was undertaken in long-term hospitalized patients aged 70-90 years and healthy young adults aged 19-40 years. The magnesium status were assessed by plasma levels and the dietary intake of magnesium. Significant correlation was observed between dietary intake and plasma levels of magnesium and it was found that plasma magnesium was decreased below the normal range in some subjects when daily intake of magnesium was below 150mg. Therefore, we assumed that the minimum requirement of magnesium for Japanese adults including aged peoples were 150mg/day. The dietary allowance should be set around 300mg/da … More y by adding safety coefficients. In future, these values should be re-estimated using stable isotope method.
To clarify the nutritional status of zinc and iron, we carried out a series of experiments in American subjects using the stable isotope ^<67>Zn. Food frequency history, serum ferritin, plasma zinc, plasma zinc disappearance, and zinc turnover rate were measured in these subjects. Plasma zinc disappearance and turnover rate were determined by inductively coupled plasma mass spectroscopic analysis of the plasma ratio of zinc 67 to zinc 68 before and 30 to 60 minutes after intravenous injection of ^<67>Zn. Data were applied the cluster analysis. The results were as follows. Frequent meat intake and vitamin C supplements were associated with hgher serum ferritin concentration and a normal plasma zinc disappearance. Serum ferritin concentration and plsma zinc disappearance constant were inversely and non-linearly related. Lower serum ferritin was associated with the faster disappearance of plasma zinc. These findings suggest that avoidance of meat increases the risk of iron and zinc deficiencies, and low serum ferritin concentrations suggest the possibility of low zinc nutriture. The problem that whether these findings in Americans are also adapted to Japanese or not are remain to be clafiried. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 糸川嘉則: "ミネラル・微量元素の栄養所要量と栄養評価法" フードケミカル. 10. 19-25 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 糸川嘉則: "長期経静脈栄養療法時における微量元素の必要性とその補充量" 日本臨牀. 54. 172-177 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 糸川嘉則: "微量元素と臨床栄養" 臨床栄養. 89. 243-250 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 糸川嘉則: "ミネラルの栄養評価と栄養所要量設定への提言" Food Style 21. 1. 80-83 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 横井克彦: "Comparison of tri-exponential and truncated models in plasma zinc(Zn)kinetics." J.Invest.Med.44. 355A (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 横井克彦: "Measurement of plasma chelatable zinc for zinc kinetic studies in humans." Fed.Am.Soc.Exp.Biol.98. 1-4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 糸川嘉則: "マグネシウム 成人病との関係" 光生館, 271頁 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 糸川嘉則: "病気と栄養" 南山堂, 438頁 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: "Dietary allowance and nutritional assessment of minerals and trace elements" Food Chemicals. 10. 19-25 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: "Requirement and supplementation of trace elements in long-term total parenteral nutrition" Nihon Rinsho. 54-1. 172-177 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: "Trace elements in clinical nutrition" Clinical Nutrition. 89-3. 243-250 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: "Nutritional assessments of minerals and a proposal on establishment of dietary allowance of minerals" Food Style 21. 1-1. 80-83 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuhiko YOKOI: "Comparison of tri-exponential and truncated models in plasma zinc (Zn) kinetics" J.Invest.Med.44. 355A (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuhiko YOKOI: "Measurement of plasma chelatable zinc for zinc kinetic studies in humans" Fed.Am.Soc.Exp.Med.98. 1-4 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: Magnesium, in relation to diseases in aged. Koseikan Co., Japan, 271 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinori ITOKAWA: Diseases and nutrition. Nanzando Co., Japan, 438 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura: "Application of nonlinear models to estimate zinc requirements of rats." International society for Trace Element Reserch in Human. September. 25-28 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 横井克彦、安井久晃、木村美恵子、糸川嘉則: "ラット組織中アンギオテンシン変換酵素(ACE)活性に及ぼす亜鉛欠乏の影響" 第50回日本栄養・食糧学会抄録集. 234. (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 横井克彦、木村美恵子、糸川嘉則: "亜鉛安定同位体を用いた人体における交換性亜鉛プールの定量" 第67回日本衛生学会. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 木村美恵子、中川晋一、張震華: "中国江鮮省における健康調査-中年女性ミネラル摂取状況-" 第67回日本衛生学会. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 池川雅哉、木村美恵子、糸川嘉則、本多和人、本山秀明、巻田和男、藤井理行: "ICP質量分析計による南極雪中の微量元素分析" 第7回日本微量元素学会抄録集. 34. (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Ikegawa,M.Kimura,K.Honda,K.Makita,Y.Fujii,Y.Itokawa: "Springtime peaks of tarce metals in east Antarctic snow." International Symosium on Environmental Reserch in the Antarctic. (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 糸川嘉則: "成人病とビタミン" 学会センター関西, 125 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 糸川嘉則: "骨粗しょう症" 学会センター関西, 96 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 糸川嘉則: "ミネラル・微量元素の栄養所要量と栄養評価法" 月刊フード ケミカル. 10月号. 19-25 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 糸川嘉則: "長期経静脈栄養療法時における微量元素の必要性とその補充量" 日本臨床. 54. 172-178 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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