| Project/Area Number |
07407026
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Tsunehiko Osaka University Medical School, Professor, 医学部, 教授 (70237733)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Tomoya Osaka University Medical School, Medical Staff, 医学部・附属病院, 基礎系医員
YAMAMOTO Haruko Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員
SEIKE Yujiro Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員
OKU Naohiko Osaka University Medical School, Medical Staff, 医学部・附属病院, 医員
HASHIKAWA Kazuo Osaka University Medical School, Lecturer, 医学部・附属病院, 講師 (70281128)
植原 敏勇 大阪大学, 医学部・附属病院, 講師 (80243202)
楠岡 英雄 大阪大学, 医学部, 助教授 (00112011)
福地 一樹 大阪大学, 医学部・附属病院, 医員
森脇 博 大阪大学, 医学部・附属病院, 医員
神長 達郎 帝京大学, 医学部, 講師
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| Project Period (FY) |
1995 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥25,400,000 (Direct Cost: ¥25,400,000)
Fiscal Year 1998: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1997: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1995: ¥13,400,000 (Direct Cost: ¥13,400,000)
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| Keywords | Metabolism / Receptor / SPECT / PET / Hypertrophic cardiomyopathy / Dilated cardiomyopathy / beta-blocker |
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| Research Abstract |
Assessment of pathophysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac . failure has been investigated by using myocardial metabolic and receptor imaging from 1995 to 1998. The following researches were done from the basic and clinical points.
1. basic research using isolated perfused rat heart and autoradiography
Metabolism of ^<123>I-BMIPP was clarified by isolated perfused rat heart model. Glucose uptake in stunned myocardium was also clarified by ^<31>P-MR spectroscopy and it was confirmed to be caused by the translocation of glucose transporter. Tracer kinetics of ^<99M>Tc-nitroimidazole was also clarified. These tracers were applied to animal models such as DCM hamster (Bio l4_<beta>6) etc. It was conformed that the metabolic and receptor changes were preceded before the flow and functional changes by autoradiography.
2. clinical research using SPECT and PET
^<123>I-BMiPP myocardial SPECT was useful for the assessment of severity of hypertrophic cardiomyopathy (HCMz) and therapeutic effect of Coenzyme Q1O in dilated cardiomyopathy (DCM). ^<123>I-MIBG was useful for the severity and therapeutic effect of BETA-blocker in DCM.Furthermore, ^<18>F-FDG myocardial PET was extremely useful for the pathophysiologic diagnosis of HCM and DCM.These findings should be necessary for the indication of heart transportation.
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