| Project/Area Number |
07408031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Osaka University |
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Principal Investigator |
NOMURA Taisei Osaka University Faculty of Medicine, Professor, 医学部, 教授 (90089871)
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| Co-Investigator(Kenkyū-buntansha) |
TODO Takeshi Kyoto University Rasiation Biology Center, Associate Professor, 放射線生物研究センター, 助教授 (90163948)
SAITO Tadashi Osaka University Radioisotope Research Center, Associate Professor, 助教授 (50153812)
NONGYO Tadashi Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (90271569)
NAKAJIMA Hiroo Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (20237275)
SUGIYAMA Haruo Osaka University Faculty of Medicine, Professor, 医学部, 教授 (70162906)
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| Project Period (FY) |
1995 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1998: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1996: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | Low dose and low dose rate radiation / Dose rate effectiveness factor / Physical risk / Genetic risk / Leukemia / Solid tumor / Mortality and malformation / Mutation |
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| Research Abstract |
1.0.5 and 1.7 Gy of ^<60>Co-gamma radiation was given to 6 weeks old C3H/HeJ and C57BL/6J mice 4 times at 7 days interval at different dose rates from 0.0002 to 0.57 Gy/min, and Dose and Dose Rate Effectiveness Factor (DDREF) was calculated for the risk estimation.
(1) There were apparent dose rate effects in leukemia induction. DDREF was 20-40. Delayed increase of solid tumors was also observed by the lowere dose rates.
(2) There was a slight reduction of solid tumors by lower dose rate in C57BL/6J mice, but nothing in C3H/HeJ mice (DDREF*1.0). However, dose rate effects were detected in the lung, breast, and pituitary tumors (DDREF*2.3).
2. Fetal deaths, malformations somatic mutation and tumors were induced in PTHTF mice after in utero doses of X-rays, ^<60>Co-rays, and ^<252>Cf neutron. About 1/3 reduction of these defects was observed by lower dose rate. RBE of ^<252>Cf was 6-9 for mutation and cancer.
3. PLDR and dose rate effects were absent or very small in double strand breaks repair deficient SCID cells, white it was obvious in wild type culture cells, indicating that dose rate effects were caused by double strand breaks repair in the most parts.
4. Measurement of the expression level of WT 1 gene is carried out for the liquidators with hematological abnormality after Chernobyl catastrophe, because it is extremely sensitive to detect leukemia in human.
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