• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dose and dose rate effectiveness to determine the risk of low dose radiation to human

Research Project

Project/Area Number 07408031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionOsaka University

Principal Investigator

NOMURA Taisei  Osaka University Faculty of Medicine, Professor, 医学部, 教授 (90089871)

Co-Investigator(Kenkyū-buntansha) TODO Takeshi  Kyoto University Rasiation Biology Center, Associate Professor, 放射線生物研究センター, 助教授 (90163948)
SAITO Tadashi  Osaka University Radioisotope Research Center, Associate Professor, 助教授 (50153812)
NONGYO Tadashi  Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (90271569)
NAKAJIMA Hiroo  Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (20237275)
SUGIYAMA Haruo  Osaka University Faculty of Medicine, Professor, 医学部, 教授 (70162906)
Project Period (FY) 1995 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1998: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1996: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsLow dose and low dose rate radiation / Dose rate effectiveness factor / Physical risk / Genetic risk / Leukemia / Solid tumor / Mortality and malformation / Mutation
Research Abstract

1.0.5 and 1.7 Gy of ^<60>Co-gamma radiation was given to 6 weeks old C3H/HeJ and C57BL/6J mice 4 times at 7 days interval at different dose rates from 0.0002 to 0.57 Gy/min, and Dose and Dose Rate Effectiveness Factor (DDREF) was calculated for the risk estimation.
(1) There were apparent dose rate effects in leukemia induction. DDREF was 20-40. Delayed increase of solid tumors was also observed by the lowere dose rates.
(2) There was a slight reduction of solid tumors by lower dose rate in C57BL/6J mice, but nothing in C3H/HeJ mice (DDREF*1.0). However, dose rate effects were detected in the lung, breast, and pituitary tumors (DDREF*2.3).
2. Fetal deaths, malformations somatic mutation and tumors were induced in PTHTF mice after in utero doses of X-rays, ^<60>Co-rays, and ^<252>Cf neutron. About 1/3 reduction of these defects was observed by lower dose rate. RBE of ^<252>Cf was 6-9 for mutation and cancer.
3. PLDR and dose rate effects were absent or very small in double strand breaks repair deficient SCID cells, white it was obvious in wild type culture cells, indicating that dose rate effects were caused by double strand breaks repair in the most parts.
4. Measurement of the expression level of WT 1 gene is carried out for the liquidators with hematological abnormality after Chernobyl catastrophe, because it is extremely sensitive to detect leukemia in human.

Report

(5 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report

Research Products

(64 results)

All Other

All Publications

  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(和文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications] 「研究成果報告書概要(欧文)」より

    • Related Report
      1998 Final Research Report Summary
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1998 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1997 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1996 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report
  • [Publications]

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi