| Project/Area Number |
07457157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Department of Neurology, Iwate Medical University |
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Principal Investigator |
TOHGI Hideo Depatment of Neurology Iwate Medical University Professor, 医学部, 教授 (90155490)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Satoshi Department of Neurology Iwate Medical University Iecturer, 医学部, 講師 (50216719)
ABE Takashi Department of Neurology Iwate Medical University Associate professor, 医学部, 助教授 (30202667)
UTSUGISAWA Kimiaki Department of Neurology Iwate Medical University Lecturer, 医学部, 助手 (00244913)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | aging / neuron death / selective vulnerability / molecular chaperone / nuclear receptors / dopamine receptor (D_1, D_2) / nicotinic acetyocholine receptor subunits(alpha4, beta2) / ニコチン性アセチルコリン受容体 / 線条体 / D_1,S_2受容体 / rt-PCR / ニューロン死 / 海馬 |
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| Research Abstract |
To investigate selsctive vulnerability of neurons in age-related neuronal death and its mechanisms, we studied changes with age in mRNA expression of a molecular chaperone (heat0shock cognate 70, hsc 70), neurtransmitter precursors (preprotechykinin and preproenkephalin), neurotransmitter receptors (dopamine D_1and D_<> receptrs), and receptor subunits (nicotinic acetylcholine receptor subunits [nAChR] alpha4 and beta2 )in differing regions (cerebral cortex, hippocampus, and putamen) of human autopsy brains. The results suggest 1) that valnerability of neurons to aging is related to expression of hsc 70, and differs between neurons with differing neurotransmitters.and 2 ) that the magnitude of the reduction with age differs between receptor subtypes for a transmitter (e.g.D_1and D_2) and between receptor subunits (e.g.nAChR alpha4 and beta2) in differing regions.
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