Grant-in-Aid for Scientific Research (A)
Biomedical engineering/Biological material science
|Research Institution||HOKKAIDO UNIVERSITY|
YASUDA Kazunori Hokkaido Univ., School of Medicine, Profcssor, 医学部, 教授 (20166507)
川崎 俊彦 (株)ユフ精器, 取締役営業部長
MIYAGI Noboru Hokkaido Univ., Hospital, Instractor, 医学部付属病院, 助手 (90261297)
WADA Tatsuhiko Hokkaido Univ., College of Med.Tech., Professor, 医療技術短期大学部, 教授 (90002112)
MATSUNO Takeo Asahikawa Univ., Hospital, Professor, 教授 (10165847)
KAWASAKI Toshihiko Yufu Seiki, Co.LTD,General manager
|Project Fiscal Year
1995 – 1997
Completed(Fiscal Year 1997)
|Budget Amount *help
¥13,200,000 (Direct Cost : ¥13,200,000)
Fiscal Year 1997 : ¥1,700,000 (Direct Cost : ¥1,700,000)
Fiscal Year 1996 : ¥3,600,000 (Direct Cost : ¥3,600,000)
Fiscal Year 1995 : ¥7,900,000 (Direct Cost : ¥7,900,000)
|Keywords||Polyester fiber / Biomaterial / Autograft / Allograft / Biomechanics / Hybrid-type synthetic ligament / High molecular fiber / 人工靭帯 / 生体材料 / 自家腱移植 / 同種膠原線維移植 / 生体工学 / ハイブリッド材料 / 高分子繊維 / 人工靱帯 / 同種腱移植 / ハイブリット材料|
l.Tensile tests after implantation demonstrated that the strength of the polyester fiber is the greatest in synthetic fibers which have favorable histocompatibility and clinical utility.
2.The tensile strength of the semitendinosus tendon is the greatest (124.3 MPa) in the collagen fiber bundles harvested from human body.
3.The alpha-type connection method between flatly knit polyester fibers and looped flexor tendons is the strongest in serial connection methods between synthetic fibers and human collagen fiber bundles.
4.The tensile strength of the femur-graft-tibia complex that has undergone ACL reconstruction using the hybrid-type synthetic ligament, where flatly knit polyester fibers are connected in series with human collagen fiber bundles using the alpha -type connection method, is approximately 900N.It is the greatest in the complexes reconstructed with currently available procedures, and is resistant to submaximal cyclic loading.
5.The collagen bundle portion in the hybrid-type sy
nthetic ligament is fixed by thick connective tissues in bone tunnels at 6 weeks postoperatively. The fixation strength is not affected by disagreement of the diameter between a graft and a bone tunnel.
6.The tensile strength of the collagen fiber bundle portion of the hybrid-type synthetic ligament changes into 59,50,5l, and 56% at 3,6,9,12, and 24 weeks, respectively, after implantation. The deterioration rate is less than that of the patellar tendon autograft at each period.
7.The tensile strength of the grafted collagen fiber bundle portion is deteriorated by both stress deprivation and stress enhancement. The deterioration rate, however, is less than that of the patellar tendon autograft.
8.Based on the above-described basic data, a clinically available hybrid-type synthetic ligament composed of synthetic polyester fibers and human collagen fiber bundles has been developed, and evaluated clinically in 110 cases of ACL reconstruction. The result demonstrated that normal stability is restored in 91% of the knees. This result is superior to that reported in previous literature. Less