|Budget Amount *help
¥1,700,000 (Direct Cost : ¥1,700,000)
Fiscal Year 1996 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1995 : ¥1,000,000 (Direct Cost : ¥1,000,000)
Ti (O-i-Pr) 4/2i-PrMgBr reagent mediates the intramolecular nucleophilic acyl substitution (INAS) reactions of unsaturated compounds to afford organotitanium compounds containing functional groups. Because of the versatility of organotitanium compounds, the chemistry developed here provides an efficient, general method for the synthesis of butenolides, butanolides, vinyl cyclic ketones, alpha, beta-unsaturated ketones, and furans. Moreover, the reaction is practical, since the starting reagents, Ti (O-i-Pr) _4 and i-PrMgBr, are inexpensive and available in bulk, and the reaction procedure is operationally simple. Thus, the reaction would find widespread usage in synthetic organic chemistry.