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A study on the effect of central neuropeptides on hepatic function.

Research Project

Project/Area Number 07670554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionAsahikawa Medical College

Principal Investigator

YONEDA Masashi  Asahikawa Medical College Second Department of Medicine Assistant Professor, 医学部, 助手 (30261407)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
KeywordsNeuropeptide / Hepatic function / Hepatic prliferation / Hepatic blood flow / Neurotrnsmitter
Research Abstract

1. The central nervous system (CNS) effect of thyrotropin releasing hormone (TRH) on hepatic microcirculation was studied in rats. Hepatic microcirculation was measured by hydrogen-gas clearance method in urethane-anesthetized rats. Intracisternal injection of TRH analog dose-dependently enhanced hepatic blood flow with peak response at 30 min. The stimulation of hepatic blood flow by central TRH was abolished by atropine, indomethacin, L-NAME and vagotomy.
2. The CNS effect of TRH on hepatic proliferation was studied in awaked rats. Hepatic proliferation was assessed by thymidine incorporation into hepatic DNA.Hepatic proliferation was dose-dependently stimulated by intracisternal TRH analog with peak response at 48 h after the peptide injection and returned to basal at 72 h. Stimulation of hepatic proliferation by central TRH was abolished by hepatic branch vagotomy, atropine and indomethacin but not by L-NAME.
3. The CNS effect of TRH and corticotropin releasing factor (CRF) on CC14-induced acute liver damage in awaked rats. Intracisternal TRH analog dose-dependently inhibited the elevation of serum ALT level 24 h after CC14 injection and this inhibitory effect was abolished by atropine, indomethacin and vagotomy, but not by L-NAME or 6-OHDA.Intracisternal CRF dose dependently enhanced hepatic damage induced by CC14.
4. The CNS effect of TRH on hepatic cAMP synthesis was studied in awaked rats. Intracisternal TRH analog stimulate hepatic cAMP synthesis with peak response at 12 h.
It is of interest to investigate specific brain sites for TRH and CRF and to evaluate a role of endogenous TRH and CRF in hepatic function using specific antibody and antagonist.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Masashi Yoneda: "Neuropeptide Y in the dorsal vagal complex stimulates bicarbonatedependent bile secretion in rats" Gastroenterology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hiroshi Itoh: "Rapid gastric emptying and pathological changes of vagus nerve in the spontaneously diabetic chinese hamster" Diabetic Research and clinical Practice. 28. 89-95 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masashi Yoneda: "Liver Innervation" Takashi Shimizu, John Libbey & Company Ltd., 484 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Itoh H,Yoneda M,Tamori K,et al.: "Rapid gastric emptying and pathological changes of the vagus nerves in the spontaneously diabetic Chinese hamsters." Diabetic Research and Clinical Practice. 28. 89-95 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoneda M,Tamori K,Sato Y,Yokohama S,Nakamura K and Makino I: "Central regulation of hepatic function by neuropeptides." Liver innervation, Ed Shimazu T.John Libbey Co.London England. 441-448 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoneda M,Yokohama S,Tamori K,et al.: "Neuropeptide Y in the dorsal vagal complex stimulates bicarbonate-dependent bile secretion in rats." Gastroenterology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masashi Yoneda: "Neuropeptide Y in the dorsal vagal complex stimulates bicarbonate-dependent bile secretion in rats" Gastroenterology. (印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiroshi Itoh: "Rapid gastric emptying and pathological changes of vagus nerve in the spontaneously diabetic Chinese hamster" Diabetic Research and clinical Practice. 28. 89-95 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masashi Yoneda: "Liver Innervation" Takashi Shimizu,John Libbey & Company Ltd., 484

    • Related Report
      1996 Annual Research Report
  • [Publications] Masashi Yoneda: "Liver Innervation" Takashi Shimazu,John Libbey & Company Ltd., (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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