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Mechamisms of death from asthma-basic and clinical approach-

Research Project

Project/Area Number 07670649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

KIKUCH Yoshihiro  Tohoku University School of Medicine, Associate Professor, 医学部, 講師 (20195217)

Co-Investigator(Kenkyū-buntansha) HIDA Wataru  Tohoku University School of medicine Associate Professor, 医学部, 助教授 (10142944)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsBrnchial asthma / death from asthma / hypoxia / Dyspnea / Carotid body / Posithon emission tomography / Positron emission tomography
Research Abstract

We have recently reported that patients with near-fatal asthma have lowered hypoxic respiratory response as well as blunted perception of dyspnea, suggesting that these two factors are predisposing factors to death from asthma attacks. We speculate that these factors may be due to dysfunction of peripheral (carotid) chemoreceptors. In this study, we have examined the relationships among death from asthma, hypoxic respiratory responses and the function of carotid body.
Our results were as follows,
(1) Using positron emission tomography, we have demonstrated that cingulate cortex, thalamus and premoter cortex were activated during inspiratory resistive loaded breathing in healthy subjects and that these areas were less activated in patients with nearfatal asthma.
(2) We have found expression of C-fos oncogen in the cingulate cortex, thalamus, hypothalamus, and pons of rats, which were exposed to hypoxia, hypercapnia or inspiratory resistance by using in situ hybridization and immunohistochemistry.. These results suggest that these area of the brain may be involved in the genesis of dyspnea and/or behavioral control of breathing during loaded breathing.
(3) The effects of doxapram on dyspnea and ventilatory response to hypoxia were examined in 7 normal subjects. Doxapram increased dyspnea snsation as well as hypoxic ventilatory response. There was a relationship dyspnea and the ablity of hypoxic ventilatory response, suggesting that carotid chemoreceptor may play some role in the genesis of dyspnea sensation.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Okabe S.et.al: "Effect of procain injection do vettlatory mudcllay shell on drciheal smoorh musile done and phsumc neursgram" Respin Physiol. 99. 89-96 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W.et.al.: "Submental stimulation and supragloffic rxsistance during breadhing" Respin Physiol. 101. 79-85 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogawa H.et al: "Role of nitric oride in the nucleus tractus solitorius during hypopic ventilctory repoxse." J.Physiol London. 486. 495-504 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mizusawa et al: "Role of parsbnal nucleus in ventilatory respinses of awake rats" J.Physiol London. 489. 877-884 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W et al: "N-acotylcysteine inhibits loss of cliaphragm funfin in strephzodocin-treated rats." Am.J.Respin critical care Med.153. 1875-1879 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okabe S et al: "Role of hypopic on increased blood prassure in patients with obstruchire sleep apicae" Thonat. 50. 28-34 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okabe S,Hida W,Chonan T,Izumiyama T,Kikuchi Y,Takishima T,Shirato K.: "Effects of procain injection to ventral medullary shell on tracheal smooth muscle tone and phrenic neurogram." Respir Physiol. 99. 89-96 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W,Kurosawa H,Okabe S,Kikuchi Y,Midorikawa J,Chung Y.-T,Shindoh C,Takishima T,Shirato K.: "Hypoglossal nerve stimulation affects the pressurevolume behavior of the upper airway." Am J Respir Crit Care Med.151. 455-460 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okabe S,Hida W,Kikuchi Y,Taguchi O,Midorikawa J,Ogawa H,Mizusawa A,Miki H,Shirato K.: "Blood pressure response to hypoxia in patients with obstructive sleep apnea." Thorax. 50. 28-34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ogawa H,Mizusawa A,Kikuchi Y,Hida W,Miki H,Shirato K.: "Role of nitric oxide in the nucleus tractus solitarius during hypoxic ventilatory response." J.Physiol London. 486. 495-504 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mizusawa A,Ogawa H,Kikuchi Y,Hida W,Shirato K.: "Role of the parabrachial nucleus in ventilatory responses of awake rats." J of Physiol London. 489. 877-884 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W,Okabe S,Miki H,Kikuchi Y,Kurosawa H,Takishima T, Shirato K.: "Submental stimulation and supraglottic resistance during mouth breathing." Respir Physiol. 101. 79-85 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W,Shindoh C,Satoh J,Sagara M,Kikuchi Y,Takayoshi T,Shirato K.: "N-acetylcysteine inhibits loss of diaphragn function in streptozotocin-treated rats." Am J Respir Crit Care Med.153. 1875-9 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Midorikawa J,Hida W,Taguchi O,Okabe S,Kurosawa H,Mizusawa A,Ogawa H,Ebihara S,Kikuchi Y,Shirato K.: "Lack of ventilatory threshold in patients with chronic obstructive pulmonary disease." Resipration. 64. 76-80 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hida W. et al: "N-acetylcysteine inhibits loss of diaphrcym function in streptozotocin-treated rats" Am. J. Respir Crit. Care Med. 153. 1875-1879 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Midorikawa J. et al.: "Lack of ventilatory threshold in patients with chromic obstructive pulimary disease." Respiration. 64. 76-80 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Okabe S. et al.: "Effects of procain injection to ventral muddloy shell on fraheal smooth muscle force and phicenic neurogram" Respir Physiol. 99. 89-96 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okabe S. et al.: "Blood pressure response to hypoxia in patients with obstructive sleep apnea" Thorax. 50. 28-34 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hida W. et al.: "Submental stimulation and supragloffic resistance during mouth breathing" Respir Physiol. 101. 79-85 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogawa H. et al.: "Role of nitric oxide in the nucleus tractus solitarius during hypoxic ventilatory response" J Physiol London. 486. 495-504 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mizusawa A: "Role of parabrachiol nucleus in ventilatory response of awake rats." J Phyiol London. 489. 877-884 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] ida W et al.: "N-acetylcysteine inhibits loss of disphragm function in streptozotocin-treated rats" Am J Respir Crit Care Med. (in press).

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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