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Development of machine measuring cough for 24 hours and its clinical application

Research Project

Project/Area Number 07670651
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

SEKIZAWA Kiyohisa  Department of Geriatric Medicine Tohoku University School of Medicine Associate Professor, 医学部・附属病院, 助教授 (50171335)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsCough / Defense mechanism / Pneumonia in the elderly / Substance P / C-fiber / Copsaicin / Airway in flammation / Bronchoal asthma / 咳反射 / 誤嚥性肺炎 / ACE阻害剤 / 睡眠 / 嚥下反射
Research Abstract

Cough is the most important symptom of respiratory disease and a decrease in cough reflex is believed to cause pneumonia. A machine continuously measuring the number of coughs during 24 hours is needed to elucidate mechanisms of cough and to control cough in patients with respiratory disease. We therefore developed the portable machine that able to count the number of coughs continuously for 24 hours and to distinguish cough from conversation. However, frictional sounds produced by interaction between a microphone and clothes had a similar power spectrum as cough sound, and therefore it was impossible to count the number of coughs. Now, we are trying to develop a new strategy for a continuous measurement of the number of coughs.
To investigate mechanisms of cough, we used awake guinea pigs for measuring the number of coughs during the treatment with phosphoramidon, an angiotensin converting enzyme inhibitor and bronchoconstriction induced by acetylcholine, histamine and ovalbumin antigen. A substance P antagonist attenuated the cough response in all cases in guinea pigs, and therefore it is suggested that substance P may be a mechanism responsible for the development of cough in the body. In humans, the levels of substance P in suputum were markedly low in patients with aspiration pneumonia who had the attenuated cough response compared to controls. These results suggest that substance P in the airway may be an important substance for causing cough and a reduction of substance P content in the airway may lead the patients to aspiration pneumonia.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 氏家祐子: "Evidence for substance Pas an endogenous substance causing cough in guinea pigs" American Review of Respiratory Disease. 148. 1628-1632 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 菊地亮: "High incidence of silent aspiration in elderly patients with community-acquired pneumonia" American Journal of Respiratory and Critical Care Medicine. 150. 251-253 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 関沢清久: "Role of substance P in cough during bronchoconstriction in awake guinec pigs" American Journal of Respiratory and Critical Care Medicine. 151. 815-821 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 勝又宇一郎: "Aging effects on cough reflex" Chest. 107. 290-291 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 中川琢磨: "Sputum substance P in aspiration pneumonia" Lancet. 341. 1447 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 海老原孝枝: "Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinec pigs" American Journal of Respiratory and critical Care Medicine. 153. 812-819 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuko Ujiie et al.: "Evidence for substance P as an endogenous substance causing cough in guinea pigs." American Review of Respiratory Disease. 148. 1628-1632 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ryo Kikuchi et al.: "High incidence of silent aspiration in elderly patients with community-acquired pneumonia." American Journal of Respiratory and Critical Care Medicine. 150. 251-253 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kiyohisa Sekizawa et al.: "Role of substance P in cough during bronchoconstriction in awake guinea pigs." American Journal of Respiratory and Critical Care Medicine. 151. 815-821 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Uichiro Katsumata et al.: "Aging effects on cough reflex." Chest. 107. 290-291 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takuma Nakagawa et al.: "Sputum substance P in aspiration pneumonia." Lancet. 341. 1447 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takae Ebihara et al.: "Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs." American Journal of Respiratory and Critical Care Medicine. 153. 812-819 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 氏家祐子: "Evidence for substance P as an endogenous substance causing cough in guinea pigs" American Review of Respiratory Disease. 148. 1628-1632 (1993)

    • Related Report
      1996 Annual Research Report
  • [Publications] 菊地 亮: "High incidence of silent aspiration in elderly patients with community-acquired pneumonia" American Journal of Respiratory and Critical Care Medicine. 150. 251-253 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 関沢清久: "Role of substance P in cough during broncho constrition in awake guinea pigs" American Journal of Respiratory and Critical Care Medicine. 151. 815-821 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 勝又宇一郎: "Aging effects on cough reflex" Chest. 107. 290-291 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 海老原孝枝: "Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs" American Journal of Respiratory and Critical Care Medicine. 153. 812-819 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 中川琢磨: "Sputum substance P in aspiration pneumonia" Lancet. 345. 1447 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] アルトール ピント: "Swallowing reflex in the night" Lancet. 344. 820-821 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中川琢磨: "Sputum substance P in aspiration pneumonia" Lancet. 345. 1447 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 海老原孝枝: "Angiotensin-converting enzyme inhibitor and danacol increase sensitivity of cough reflex on female guinea pigs" Am J Respli Crit Care Med. 153. 812-819 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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