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Abnormal excitability of a spinal motoneuron in patients with amyotrophic lateral sclerosis.

Research Project

Project/Area Number 07670710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KOHARA Nobuo  Kyoto University, Medical School, Assistant, 医学研究科, 助手 (20252439)

Co-Investigator(Kenkyū-buntansha) KAJI Ryuji  Kyoto University, Medical School, Lecturer, 医学研究科, 講師 (00214304)
KIMURA Jun  Kyoto University, Medical School, Professor, 医学研究科, 教授 (10204976)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsALS / MND / magnetic stimulation / corticospinal tract / PSTH / motor unit / pyramidal tract / motor neuron disease / 錐体的 / ALS(筋萎縮性側索硬化症) / MND(運動ニューロン障害) / PSTH(Peristimulus Time Histogram) / Magnefic Stimulation / Corticospinal tract
Research Abstract

The pathophysiology of corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) was investigated by studying the effect of transcranial magnetic stimulation on discharge characteristics of single motor units during voluntary activation. The motor units were recorded from the first dorsal interosseus muscles of 12 patients with ALS,14 healthy subjects, 12 patients with upper motor neuron lesions and 9 with pure lower motor neuron diseases. More than 100 magnetic stimuli were delivered over the scalp during minimal muscle contraction. The occurrence of motor unit discharges was plotted in a peristimulus time histogram. An increase in discharge probability at latencies of 20-30 msec, that represents monosynaptic activation (primary peak) was found in normal units. Motor units from ALS patients with short disease durations had significantly increased discharge probabilities in the primary peak (p<0.01). Motor units from 4 ALS patients with upper motor neuron signs showed double primary peaks ; an initial synchronized peak followed by a dispersed peak. The latter was ascribed to a slow corticospinal pathway, which remains undetected or is functionally insignificant in healthy subjects. We conclude that the excitabilities of the surviving corticospinal tract pathways ate abnormally increased in ALS,especially in the early stage.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Kohara N, Kaji R, Kojima Y, et al.: "Magnetic stimulation in ALS; a single motor unit study using transcranial magnetic stimulation." Electroenceph. clin. Neurophysiol. Suppl 46. 327-336 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N, Kaji R, Kojima Y, et al.: "Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis : a single motor unit study using transcranial magnetic stimulation." Electroencephalogr and clin neurophysiol. 101. 32-41 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N, Kaji R, Kojima Y, Mills K, Fujii H, Hamano T.: "Increased excitability of the corticospinal neurons in patients with amyotrophic lateral sclerosis. In : Kimura J, Shibasaki H eds." Recent Adv in Clin Neurophysiol. Amsterdam : Elsevier. 91-96 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 幸原 伸夫、小島 康祐: "筋萎縮性側索硬化症の運動ニューロンの障害" 臨床脳波. 37. 576-579 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 幸原 伸夫: "大脳磁気刺激法を用いた運動ニューロン機構の研究 一筋萎縮性側索硬化症(ALS)の病態解明をめざして。板倉徹、前田敏博編 大脳皮質運動領野" 東京:ブレーン出版. 65-81 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N,Kaji R,Kojima Y,et al.: "Magnetic Stimulation in ALS ; a single motor unit study using transcranial magnetic stimulation." Electroenceph.clin.Neurophysiol. Suppl.46. 327-336 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N,Kaji R,Kojima Y,et al.: "Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis : a single motor unit study using transcranial magnetic stimulation." Electroenceph.clin.Neurophysiol. 101. 32-41 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N,Kaji R,Kojima Y,Mills K,Fujii H,Hamano T.: "Increased excitability of the corticospinal neurons in patients with amyotrophic lateral sclerosis." In ; Kimura J,Shibasaki H eds.Recent Adv in Clin Neurophysiol.91-96 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N and Kojima Y.: "Disorders of motoneurons in patient with ALS." Clinic.electroenceph.576-579 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N.: Function of corticomotoenruonal system in ALS investigated by transcranial magnetic stimulation.In ; Itakura T,Maeda T eds.Motor cortex Tokyo : Brain shuppan,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohara N,Kaji R,Kojima Y,et al.: "Magnetic stimulation in ALS ; a single motor unit study using transcranial magnetic stimulation." Electroenceph.clin.Neurophysiol. supp146. 327-336 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kohara N,Kaji R,Kojima Y,et al.: "Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis : a single motor unit study using transcranial magnetic stimulation." Electroencephalogr and clin neurophysiol. 101. 32-41 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kohara N,Kaji R,Kojima Y,Mills K,Fujii H,Hamano T.: "Increased excitability of the corticospinal neurons in patients with amyotrophic lateral sclerosis. In : Kimura J,Shibasaki Heds." Recent Adv in Clin Neurophysiol. Amsterdam : Elsevier. 91-96 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 幸原伸夫、小島康祐: "筋萎縮性側索硬化症の運動ニューロン障害" 臨床脳波. 37. 576-579 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kohara, N, Kaji R etal: "Abnormal excitability of the corticospinal pathway in patients with awyotrophic lateral sclerosis" Electroencephalogra pley and Elirical Neurphyciolgy. (in press).

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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