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The Effect of Neurotrophic Factor MK on the Expression and Repair of Brain injury

Research Project

Project/Area Number 07670718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKagoshima University

Principal Investigator

YOSHIDA Yoshihiro  School of Allied Medical Sciences, Kagoshima University Assistant Professor, 医療技術短期大学部, 助教授 (10107906)

Co-Investigator(Kenkyū-buntansha) OZAWA Masayuki  Faculty of Medicine, Kagoshima University Professor, 医学部, 教授 (90136854)
OSAME Mitsuhiro  Faculty of Medicine, Kagoshima University Professor, 医学部, 教授 (10041435)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsNeurotrophic factor / Midkine / cerebral infarction / rat / GFAP / astrocytes / 脳虚血けいれん / 胎児脳形成 / ヘパリン / 脳虚血 / BDNF / NGF / HSP70 / 神経細胞
Research Abstract

Midkine (MK) was found as a product of retinoic acid responsive gene and a protein, which has a promoting effect of growth or diferetiation on the cultured cells. It is so called on of the neurotrophic factor because of the repairing effects of the degeneration of neuron in culture. We found that MK express penubral area around the infarct of rat experimental infarct in the early stage. Furthermore, MK were found in the astrocytic cytoplasm in 2 days after the infarction by double staining of both anti-glial fibrillary acidic protein antibody and anti-MK antibody. MK was found in the neuropil on the 4 days after the infarction, where MK was stained in the swollen astrocytic processes. AP-1 responsive element was recognized in the upper sites of MK genom. Accordingly MK was thought to express through the AP-l, immediate early gene product. In human cerebral infarctin MK was expressed in the early stage.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Yoshihiro, Yoshida: "Midkine is present in early.stage of cerebral infarction" Dev Brain Res. 85. 25-30 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hiroya, Obama: "Midkine (MK) expression in extraembryonic tissues amniotic fluid and cerebrospinal fiuid during embryogemests" J.Biochem. 118. 88-93 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sha-yan Wang: "Midkine exists in astrocytes in the early stage of cerebral infarction" Dev Brain Res. 106. 205-209 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉田 義弘: "ラット脳梗塞における神経栄養因子ミッドカインの発現" 鹿児島血管障害研究会会誌. 13. 45-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉田 義弘: "脳虚血マウスにおける神経栄養因子ミッドカインの発現" 鹿児島血管障害研究会会誌. 14. 61-64 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉田 義弘: "ラット脳梗塞、マウス脳虚血、ラット脳損傷によるミッドカインの発現" Brain Hypoxia. 10. 41-4 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshihiro yoshida: "Midkine is present in the early stage of cerebral infarction." Dev Brain Res. 85. 25-30 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hiroya Obama: "Midkine (MK) expression in extraembryonic tissues, amniotic fluid, and cerebrospinal fluid during mouse embryogenesis." J Biochem. 118. 88-93 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sha-yan Wang: "Midkine exists in astrocytes in the early stage of cerebral infarction." Dev Brain Res. 106. 205-209 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshida,Y: "Midkine is present in the early stage of infarct" Dev Brain Res. 85. 25-30 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Obama H: "Midkine (MK) expression in extraembryonic tissues,amniotic fluid,and cerebrospinal fluid during mouse embryogenesis" J Biochem. 118. 88-93 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉田義弘: "ラット脳梗塞における神経栄養因子ミドカインの発現" 鹿児島脳血管障害研究会会誌. 13. 45-48 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉田義弘: "脳梗塞,脳虚血ラットにおける神経栄養因子ミッドカインの発現〜第2報〜" 鹿児島脳血管障害研究会会誌. 14. 61-64 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉田義弘: "ラット脳梗塞、マウス脳虚血、ラット脳損傷によるミッドカインの発現" Brain Hypoxia. 10. 41-47 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshida Y: "Midkine is present in the early stage of cerebral infarct" Dev.Brain Res. 85. 25-30 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Obama H: "Midkine(MK) expression in extracmbryonic tissues,amniotic fluid,and cerebrospinal fluid during mouse embryogenesis." J.Biochem. 118. 88-93 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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