| Project/Area Number |
07671042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHMORI Tetsuro Hokkaido Univ.Medicine, Associate Professor, 医学部, 助教授 (00221135)
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| Co-Investigator(Kenkyū-buntansha) |
ODAGAKI Yuji Hokkaido Univ.I Medical Hospital.Lecturer, 医学部・附属病院, 講師 (10221160)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Schizophrenia / Methamphetamine / Sensitization / Environment / Glutamate / GABA / Acetylcholine / Sch:zophven:a / Wethawphetaw:ne / Behav:or |
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| Research Abstract |
Repeated administration of methamphetamine results in schizophrenia-like phychosis in human and behavioral sensitization in animals. Understanding of behavioral sensitization may provide insight into the pathogenesis of both methamphetamine-induced phychosis and schizophrenia.
1) Rats repeatedly received methamphetamine in a small cage did not show enhancement in locomotoer activity but showed enhancement in stereotyped behavior, suggesting that environment modifies the expression of behavioral sensitization.
2) Scopolamine, an antagonist of muscarinic cholinergic receptors, prevented behavioral sensitization. Central cholinergic receptors seem to play a role in the development of behavioral sensitization.
3) Clonazepam, and agonist of central GABA-benzodiazepine receptors, prevented behavioral sensitization. Central GABA neurotransmission seems to play a role in the development of behavioral sensitization.
These results, taken together with the reports showing glutamate antagonists and protein synthesis inhibitors also prevent sensitization, may indicate that behavioral sensitization have some common properties with other neural plastic change such as learning and memory.
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