Development of a new monitoring for spinal cord ischemia using intrathecal POィイD22ィエD2 measuring
Project/Area Number |
07671473
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Oakayama University |
Principal Investigator |
UCHIDA Hatsuzo Medical School, Okayama University, Lecturer, 医学部, 講師 (40033344)
|
Co-Investigator(Kenkyū-buntansha) |
角南 博 岡山大学, 医学部・附属病院, 医員
田辺 敦 岡山大学, 医学部・附属病院, 医員
|
Project Period (FY) |
1995 – 1996
|
Project Status |
Completed (Fiscal Year 1996)
|
Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
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Keywords | thoracic aortic surgery / spinal cord ischemia / intrathecal PO2 / spinal feeding arteries / 髄腔内酸素分圧 / 脊髄潅流動脈 / 合併症 / 対麻痺 / 酸素分圧 / モニター法 / 前脊髄動脈 |
Research Abstract |
We designed a new monitoring method, intrathecal PO2 monitoring, for spinal cord ischemia during thoracic aortic surgery. And we examined correlation of intrathecal PO2 (I-PO2) with spinal cord PO2 (S-PO2), accuracy of identification method of the spinal feeding arteries using it, and efficacy of the method of protecting spinal cord from ischemia with perfusing the spinal feeding arteries. First, we examine the correlation coefficient of intrathecal PO2 with spinal cord PO2 by creating stepwisely increasing spinal ischemia. Changes of I-PO2 correlates with those of S-PO2 with the correlation coefficient 0.927±0.060, which was better than the coefficient of epidural PO2 (E-PO2) 0.847±0.085. We assumed that I-PO2 is good enough as a monitoring method reflecting the spinal blood flow. Second, we tried to identify the spinal feeding arteries among a lot of intercostal or lumbar arteries by injecting oxygenated saline. By injecting oxygenated saline into the spinal feeding arteries, the spike-like increase of I-PO2 was obtained. After the examination of the anatomy of the spinal cord, the accuracy of this method was 84.6% overall. Third, by perfusing the oxygenated blood into arteries identified as spinal perfusing arteries, we obtained the PO2 recovery of 45.3±21.4% comparing the PO2 before clamp, and ESP recovery of 37.0±24.4%. We assume that, with this method, we can extend the duration of the cross clamping time with safe, and moreover we can monitor the blood flow recovery with I-PO2 monitoring. With these facts we got, by monitoring I-PO2 we will be able to continuously monitor the blood flow change of spinal cord, and to identify the spinal feeding arteries during operation, and to prevent spinal ischemia by perfusing the identified arteries and reconstructing those arteries.
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Report
(3 results)
Research Products
(4 results)