Analysis the Modes of Three-Dimensional Invasion of Squamous Cell Carcinoma of the Tongue in Relation to Cervical Lymph Node Metastasis
Grant-in-Aid for Scientific Research (C)
|Research Institution||Kurume University|
TANAKA Shunichi Medical department Kurume University Lecturer, 医学部, 講師 (20188303)
|Project Fiscal Year
1995 – 1996
Completed(Fiscal Year 1996)
|Budget Amount *help
¥2,300,000 (Direct Cost : ¥2,300,000)
Fiscal Year 1996 : ¥1,400,000 (Direct Cost : ¥1,400,000)
Fiscal Year 1995 : ¥900,000 (Direct Cost : ¥900,000)
|Keywords||tongue cancer / cervical lymph node metastasis / mode of invasion / tumor-host interface / 3 dimensional structure / 舌癌 / 頚部リンパ節転移 / 腫瘍の浸潤様式 / 腫瘍宿主境界 / 三次元構造 / 頚部転移 / 浸潤様式 / 立体構造 / 舌扁平上皮癌 / 頸部リンパ節転移|
The relationship between the three-dimmensional form of tumor-host interface and cervical lymph node metastasis was studied in cases of primary tongue cancer. To this end, 45 cases of T1 and T2 tongue cancer were examined as to : (1) the three-dimensional from of the tumor-host interface of primary tongue cancer, (2) the distribution of each mode of tumor invasion within the primary tumor lesion, and (3) three-dimensional structure of the cancer nest at the tumor-host interface.
Gemetrical analysis of the tumor-host interface of primary tongue cancers revealed that the degree of complexity of the interface and the manner of spread of interface towards the deeper tissue are factors determining the likelihood of cervical lymph node metastasis.
Histopathological analysis of the tumor-host interface of primary tongue cancers showed that the presesce of diffuse (D type) mode of invasion at the interface and the extent of this mode of invasion are factors related to cervical lymph node metasta
sis of tongue cancer. However, the distribution of D type mode of invasion within the primary cancer lesion was variable (localized, scattered or extesive) and did not seem to be related to cervical lymph node metastasis.
When the relationship between geometical and histopathological features of the tumor-host interface was analyzed, we found that the distribution of well type (W type) mode of invasion was related to the manner of spread of the interface towards the deeper tissue, but we observed no particular relationship between the distribution of D type mode of invasion and the geometrical features of the tumor-host interface.
The cancer nest at the tumor-host interface had a three-dimensional structure related to the mode of tumor invasion. When the relationship between the cancer nest's three-dimensional structure and cervical lymph node metastsis was analyzed, the process-like or net-like structure of the D type invasion area and the rod-like structure of the W type invasion area were found as major three-dimensional structures related to cervical lymph node metastasis.
These results suggest that three-dimensional form of the tumor-host interface in primary lesions of tongue cancer is related to cervical lymph node metastasis, and that the degree of complexity of the interface, the manner of spread of the interface towards deeper tissue and the three-dimensional structure of cancer nest are probably useful in predicting the pressibility of cervical lymph node metastasis of tongue cancer.
Research Output (8results)