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Studies on Bioactive Phenolic Compounds from Traditional Herbal Medicines.

Research Project

Project/Area Number 07672282
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

NISHIBE Sansei  Health Sciences Univ.of Hokkaido, Faculty of Pharm.Sciences, Professor, 薬学部, 教授 (40101290)

Co-Investigator(Kenkyū-buntansha) KODAMA Asaka  Health Sciences Univ.of Hokkaido, Faculty of Pharm.Sciences, Assistant, 薬学部, 助手 (20285521)
TAKENAKA Takako  Health Sciences Univ.of Hokkaido, Faculty of Pharm.Sciences, Assistant, 薬学部, 助手 (10265085)
MURAI Michiko  Health Sciences Univ.of Hokkaido, Faculty of Pharm.Sciences, Assistant, 薬学部, 助手 (10205883)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordstraditional herbal medicine / phenolic compound / lignan / flavonoid / coumarin / phenylethanoid glycoside / anticancer activity / anti-allergic activity / シャゼンソウ / レンギョウ / シンピ / 抗アレルギー / 絡石藤 / ニチニチソウ / ヒメツルニチニチソウ
Research Abstract

1. The screening assay for anticancer activity
(1) Arctigenin and trachelogenin, lignans from Caulis Trachelospermi, were shown to have a high inhibitory effect on TPA-induced ear edema, which reflects an antitumor-promoting effect in two-stage carcinogenesis.
Luteolin and its 7-O-glycosides, flavonoids from Caulis Trachelospermi, showed a strong DPPH radical-scavenging activity.
(2) Mauritianin, a flavonoid from Herba Catharanthi, enhanced the TPA-suppressed delayd type hypersensitivity reaction in mice, indicating that mauritianin may augument the resistance of the immune system to cancer.
(3) 2,3-Dihydroxybenzoic acid from Periwinkle showed a strong DPPH radical-scavenging activity, which is associated with a lower risk of cancer, and prevented the formation of advanced glycation end productions (AGEs), which may reduce development of diabetic complications.
(4) Syringaresinol-di-glucoside, a lignan from Eleutherococcus, displayd an antigastric ulcer effect in restrained, cold-water-stressed rats.
2.The screening assay for anti-allergic activity
(1) Plantamajoside, a phenylethanoid glycoside from Plantago Herb, and scutellarein and 6-hydroxyluteolin, flavonoids from Plantago Herb, were shown to have inhibitory activity on 5-lipoxygenase, which has the relationship with anti-allergy. Flavonoids showed anti-histamine release activity from mast cells. Phenylethanoid glycosides showed inhibitory activity on arachidonic acid-induced mouse ear edema.
(2) Forsythiaside, suspensaside and acteoside, phenylethanoid glycosides from Forsythiae Fructus, showed a potent inhibitory activity on 5-lipoxygenase and a strong DPPH radical-scavenging activity, which have the relationship with anti-allergy.
(3) Esculetin, a coumarin from Cortex Fraxini, showed strong inhibitory activities on 5-lipoxygenase, aldose reductase and rabbit platelet aggregation. Also esculletin showed a strong DPPH radical-scavenging activity.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Sansei Nishibe: "Bioactive Phenolic Compounds for Cancer Prevention from Herbal Medicines" International Confevence on Food Factors. 86 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Michiko Murai: "Phenylethanoids in the Herb of Plantago lanceolata and Inhibitory Effect on Arachidonic Acid-Induced Mouse Ear Edema" Planta Medica. 61(5). 479-480 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西部三省: "ハ-ブ・オオバコの生理活性成分" Food & Food Ingredients Journal of Japan. 166(1). 43-49 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Studies on Constituents of Plantage Herba 7" Natural Medicines. 49(3). 340-342 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西部三省: "柴胡清肝湯(2)重要構成生薬解説・連翹" 日病薬誌. 32(1). 95-96 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Bioactive Phenolic Compounds from Catharanthus roseus and Vinca minor" Natural Medicines. 50(6). 378-383 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西部三省 他: "Studies in Natural Products Chemistry Volume 18" Elsevier Science B.V., 620 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Bioactive Compounds of Plantago Herb" FFI Journal. 166. 43-49 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "A Phenylethanoid Glycoside from Plantago asiatica" Phytochemistry. 38 (3). 741-743 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Studies on Constituents of Plantaginis Herba 7. Flavonoids from Plantago asiatica and P.hostifolia" Natural Medicines. 49 (3). 340-342 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshihito Okada: "Search for Naturally Occurring Substances to Prevent the Complications of Diabetes. II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation" Chem.Pharm.Bull.43 (8). 1385-1387 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Michiko Murai: "Phenylethanoids in the Herb of Plantago lanceolata and Inhibitory Effect on Arachidonic Acid-Induced Mouse Ear Edema" Planta Med.61 (5). 479-480 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Michiko Murai: "Iridoids from Plantago major" Natural Medicines. 54 (4). 306 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takahiko Fujikawa: "Protective Effects of Acanthopanax senticosus Harms from Hokkaido and Its Components on Gastric Ulcer in Restrained Cold Water Stressed Rats" Biol.Pharm.Bull.19 (9). 1227-1260 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Bioactive Phenolic Compounds from Catharanthus roseus and Vinca minor" Natural Medicines. 50 (6). 378-383 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tomonori Nakamura: "Acteoside as the Analgesic Principle of Cedon (Lippia triphylla), a Peruvian Medicinal Plant" Chem.Pharm.Bull.45 (3). 499-504 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "Penolic Compounds from Fruit of Forsythia japonica and F.giraldiana" Natural Medicines. 51 (4), (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sansei Nishibe: "On the Constituents of Bark of Fraxinus americana" Natural Medicines. 51 (5), (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Atta-ur-Rahman (ed.): "Masao Arimoto, H.Yamaguchi, S.Nishibe, Studies in Natural Products Chemistry, Vol.18, Structure Elucidation and Synthesis of the Lignans from the Seeds of Hernandia ovigera L." Elsevier Science B.V.NLD. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 西部三省: "柴胡清肝湯(2)重要構成生薬解説・連翹" 日病薬誌. 32(1). 95-96 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sansei Nishibe: "Iridoids from Plantago major" Natural Medicines. 50(4). 306- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sansei Nishibe: "Drotective Effects of Acanthopanax senticosus Harms from Hokkaido and Its components on Gastvic Ulcer in Restrained Cold Water Stressed Rats" Biol.Pharm.Bull.19(9). 1227-1230 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sansei Nishibe: "Bioactive Phenolic Compounds from Catharanthus roseus and Vinca minor" Natural Medicines. 50(6). 378-383 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sansei Nishibe: "Phenolic Compounds from Fruits of Forsychia Japonica and F.giraldiana" Natural Medicines. 51(4)(掲載決定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asaka Kodama: "On the Constituents of Bark of Fraxinus americana" Natural Medicines. 51(5)(掲載決定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 西部三省他: "Studies in Natural Products chemistry vdume 18" Elsevier, 620 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sansei Nishibe: "Bioactive Phenolic Compounds for Cancer Prevention from Herbal Medicines" International Conference on Food Factors. 86 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Michiko Murai: "Phenylethanoids in the Herb of Plantago Ianceolata and Inhibitory Effect on Arachidonic Acid-Induced Mouse Ear Edema" Planta Medica. 61. 479-480 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 西部三省: "ハ-ブ・オオバコの生理活性成分" Food & Food Ingredients Journal of Japan. 166. 43-49 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sansei Nishibe: "Studies on Constituents of Plantago Herba 7" Natural Medicines. 49. 340-342 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshihito Okada: "Search for Naturally Occurring Substances to Prevent the Complications of Piabetes II." Chem. Pharm. Bull.43. 1385-1387 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sansei Nishibe: "A Phenylethanoid Glycoside from Plantago asiatica" Phytochemistry. 38. 741-743 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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