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Ontogenetic changes in heartbeat fluctuation and nonlinear interactions between neural oscillators

Research Project

Project/Area Number 07680931
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KAWAHARA Koichi  Hokkaido Univ., Res.Inst.for Electr.Sci., Prof., 電子科学研究所, 教授 (20125397)

Co-Investigator(Kenkyū-buntansha) TAKEI Yoshiaki  Kobe Univ., Fac.of Human Develop., Assoc.Prof., 発達科学部, 助教授 (40188149)
YAMAUCHI Yoshiko  Hokkaido Univ., Res.Inst.for Electr.Sci., Res.Assoc., 電子科学研究所, 助手 (50230313)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordschick embyos / heartbeat period / fluctuation / ontogeny / neural oscillators / nonlinear interactions between oscillators
Research Abstract

In this research project, we have tried to elucidate the ontogenetic changes of heart beat period fluctuations in chick embryos. The results obtained from this study are summarized as follows :
(1) Electrocardiogram (ECG) colud be recorded from chick embryos at about the 10th day of incubation (DI). During this period, there was little fluctuation in heartbeat periods. However, the heartbeat fluctuation, especially the low-frequency components of it, became greater as the DI increased.
(2) The spectrum analysis of heartbeat fluctuation disclosed that the power spectral density of the heartbeat periods was almost flat like a white noise in the early period of incubation. However, the spectral density became inversely proportional to the frequency as embryos grew up, and finally showed the characteristics of 1/f fluctuation at the 17th or 18th DI.
(3) A spectral component representing the respiratory modulation of the heartbeat was first observed at about 10th DI,and the component became greater during development of the chick embryos.
(4) A model study using mutually interacting nonlinear BVP oscillators showed that a bunch of oscillators functions as a single "limit-cycle oscillator" when the coupling strength between them is strong.
All the above results suggested that the autonomic nervous control of the heart may fully developed by about the 17ty DI,and that the spectral changes of heartbeat fluctuation may reflect the ontogenetic process of the autonomic nerve innervation of the heart.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 河原: "生体におけるリズム現象の制御とゆらぎに関する研究" 電子科学研究. 4. 33-39 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 河原: "生体リズムゆらぎの機能的解釈" 医用電子と生体工学(BME). 11. 66-74 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 原田、山内、中村、河原: "単離心筋培養系における拍動リズムのダイナミクス" 信学技報. MBE96-34. 1-6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 新関、河原、宮本: "Cardiac, respiratory, and locomotion coordination during walking in humans." Folia Primatol.66. 226-239 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山内、原田、中村、河原: "培養心筋細胞の拍動リズムゆらぎとダイナミクスの解析" 生体生理工学シンポジウム論文集. 11. 113-116 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山内、原田、中村、河原: "Rhythm dynamics of spontaneously beating cardiac myocytes of neonatal rats in culture" Proc. 2nd IMIA-IFMBF Internat. Workshop on Biosignal Interpretation. 51-54 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Kawahara: "Functional interpretation of the fluctuations in biorogical rhythm" Bio-Med.Engineering. 11. 66-74 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Niizeki, K.Kawahara and Y.Miyamoto: "Cardiac, respiratory, and locomotor coordination during walking in humans" Folia Primatol.66. 226-239 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamauchi, A.Harada, T.Nakamura and K.Kawahara: "Rhythm dynamics of spontaneously beating cardiac myocytes of neonatal rats in culture" Proc.2nd IMIA-IFMBE Internat. Workshop on Biosignal Interpretation. 51-54 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nakamura, Y.Yamauchi and K.Kawahara: "Valid method to evaluate the slope of Fourier transformed spectrum for the analysis of biological rhythm fluctuation" Bio-Med.Mater.Engng. 5. 21-28 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nakamura, K.Kawahara, M.Kusunoki, T.Hara and I.Minejima: "Involvement of the nervous system in the control of glucose uptake in contracting muscle in the rat" Hormone & Metab.Res. (in submission).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamauchi, T.Nakamura and K.Kawahara: "Spectral analysis on heart beat period fluctuations in developing chick embryos" (in preparation).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 河原: "生体におけるリズム現象の制御とゆらぎに関する研究" 電子科学研究. 4. 33-39 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 河原: "生体リズムゆらぎの機能的解釈" 医用電子と生体工学(BME). 11. 66-74 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 原田、山内、中村、河原: "単離心筋培養系における拍動リズムのダイナミクス" 進学技報. MBE96-34. 1-6 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 新関、河原、宮本: "Cardiac, respiratory, and locomotion coordination during walking in humans" Folia Primatol.66. 226-239 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山内、原田、中村、河原: "培養心筋細胞の拍動リズムゆらぎとダイナミクスの解析" 生体生理工学シンポジウム論文集. 11. 113-116 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山内、原田、中村、河原: "Rhythm dynamics of spontaneously beating cardiac myocytes of neonatal rats in culture" Proc. 2nd IMIA-IFMBF Internat. Workshop on Biosignal Interpretation. 51-54 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山内,中村、河原: "鶏胚における心拍リズムゆらぎの発生過程における変化" 医用電子と生体工学. 33. 231 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山内,松浦,中村,河原: "単離心筋細胞培養系における生体振動子のダイナミクスとゆらぎの解析" 生体生理工学シンポジウム論文集. 10. 357-360 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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