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New Approaches to Chemical System Designing in Kinetic-Differentiation Capillary Electrophoresis Separations of Metal and Molecular Complexes.

Research Project

Project/Area Number 08405053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 工業分析化学
Research InstitutionTohoku University

Principal Investigator

YOTSUYANAGI Takao  Graduate School of Engineering, Tohoku University Professor, 大学院・工学研究科, 教授 (00001199)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Akira  Graduate School of Engineering, Tohoku University Professor, 大学院・工学研究科, 教授 (50093076)
MIYANO Sotaro  Graduate School of Engineering, Tohoku University Professor, 大学院・工学研究科, 教授 (60005501)
KANEKO Emiko  Graduate School of Engineering, Tohoku University Research Associate, 大学院・工学研究科, 助手 (00241539)
HOSHINO Hitoshi  Graduate School of Engineering, Tohoku University Associate Professor, 大学院・工学研究科, 助教授 (20124620)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥31,200,000 (Direct Cost: ¥31,200,000)
Fiscal Year 1998: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1997: ¥15,900,000 (Direct Cost: ¥15,900,000)
Fiscal Year 1996: ¥11,900,000 (Direct Cost: ¥11,900,000)
Keywordscapillary electrophoresis / polymer electrolytes / thiacalixarenes / metal complexes / computer chemistry / molecular recognition / chiral recognition / molecular dynamics / 金属包接錯体 / 分子設計 / ポリアミノカルボン酸 / ビナフタレン
Research Abstract

The aim of this research project is the exploitation of novel CE separation modes for metal- and molecular complexes via a better understanding of the underlying solution chemistry of the CE separation, and the molecular designing approach for derivatizing ligands bifurcaied into the organic synthesis methodology and the computational chemistry.
(1) Ionic mobilities are controlled by ion-ion interactions in eiectropnoretic buffer solutions ; an addition of polymer electrolyte such as poly(diallyldimethyi ammonium chioride) was found to be very effective for the fine separation of anionic metal chelates of poiyaminocarboxyiaies, EDTA, Quin 2, and HBED complexes.
(2) The dissociation kinetics of 2,2'-dihydroxyazobenzene-5,5'-disulfonate chelates of AI(III), Ga(III), and In(III) ions in a CZE system were investigated, developing a new method for electroosmotic flow control by the pretreatment of the capillary tube with an acidic buffer solution.
(3) Gel (molecular Sieving) CE was applied to … More the monitoring of naturally-occurring organics of humic and fulvic acids using polyacrylamide and cellulose as gel matrices. This methodology makes good contribution to the water quality assessment technology.
(4) Some new methods were developed for the preparation of various kinds of thiacalixarenes compounds, and the suitability for the CE separation systems was examined in terms of metal ion recognition and chiral separations. Also it was found that a certain kind of this ligand specifically works as a receptor for haloorganics.
(5) An approach of the molecular designing based on the computational chemistry was attempted ; an integrated computational system was constructed with the aid of density functional calculations, quantum molecular dynamics, the Monte Carlo method, and computer graphics. This system enables ones to make a fast calculation of the electronic states and structures of ligands under finite temperature and pressure, which is expected to be a very helpful and versatile tool for the molecular designing on a predicted proposition basis. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report

Research Products

(52 results)

All Other

All Publications (52 results)

  • [Publications] O.V.Krokhin: "Simultaneous determination of inorganic anions and equally charged complexes of transition metals with polyaminocarboxylic acids by capillary electrophoresis." Chemistry Letters. 1095-1096 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 鈴木俊夫: "キャピラリー電気泳動法によるフミン物質のキャラクタリゼーション" 分析化学,. 46, 6,. 477-482 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.V.Krokhin: "Use of Cationic polymers for simultaneous determination of inorganic anions and metal-4-2-(2-pyridylazo) resorcinolato chelates in kinetic differentiation-mode capillary electrophoresis." Journal of Chromatography,. 776. 329-336 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.V.Krokhin: "Influence of cationic polymers on separation selectivity in kinetic differentiation mode capillary electrophoresis of metal-4-(2-pyridylazo) resorcinolato chelates." Journal of Chromatography, A.772. 339-346 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Hattori: "Highly Stereospecific Conversion of Planar Chirality of a Cyclophane into Axial Chirality of Binaphthyls" Tetrahedron Lett.37, (12). 2057-2060 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kumagai: "Facile Synthesis of p-tert-butylthiacalix [4] arene by the reaction of p-tert-butyl-phenol with elemental sulfur in the presence of a base." Tetrahedron Lett.38, 22,. 3971-3972 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "High Compiexation Ability of Thiacalixarene to Transition Metal Ions. The Effect of Replacing Methylene Bridges of Tetra (p-t-butyl) calix [4] arenetetrol by Epithio Group" Bull.Chem.Soc.Jpn.71(7). 1597-1603 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "Selective Oxidation of Thiacalix [4] arenes to the Sulfinyl-and Sulfonylcalix [4] arenes and Their Coordination Ability to Metal lons" Tetrahedron Lett.39(41). 7559-7562 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "Selective Synthesis of Three Different Isomers of Tetrakis [(ethoxycarbonyl)methoxy]-thiacalix[4]-arene and Their Complexation Properties Towards Alkali Metal lons" Journal of the Chemical Society, Perkin Trans.2. (12). 2745-2750 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] E.Broclawik: "On the Electronic Structure of the Palladium Monoxide and the Methane Adsorption : Density Functional Calculations." The Journal of Chemical Physics,. 104. 4098-4104 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Oumi: "The Structure and Electronic Characteristics of Metallosilicates with ZSM-5 Structure." Catal.Lett.45. 21-26 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Sato: "Molecular Dynamics Simulation of Metal Porphyrin Complex Encapsulated in Zeolite." Appl.Surf.Sci.119. 346-350 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.Chatterjee: "Application of lntegrated Computer Simulation Approach to Solid Surfaces and Interfaces." Catalysis Surveys from Japan. 2. 133-154 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Sato: "The Dynamics Study of Metallocene Catalyst Using Molecular Dynamics" Applied Surface Science,. 130-132. 501-505 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.Yamada: "Tight-binding Molecular Dynamics Simulation of Desorbed SiO Molecule during the Oxidation of Si(III) Surface" Japanese Journal of Applied Physics,. in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.V.Krokhin: "Simultaneous determination of inorganic anions and equally charged complexes of transition metals with polyaminocarboxylic acids by capillary electrophoresis" Chemistry Letters. 1095-1096 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Suzuki: "Capillary Electrophoresis for the Characterization of Humic Substances" Bunnseki Kagaku. 46,6. 477-482 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.V.Krokhin: "Use of Cationic polymers for simultaneous determination of inorganic anions and metal-4- (2-pyridylazo) resorcinolato chelates in kinetic differentiation-mode capillary electrophoresis" Journal of Chromatography. 776. 329-336 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] O.V.Krokhin: "Influence of cationic polymers on separation selectivity in kinetic differentiation mode capillary electrophoresis of metal-4- (2-pyridylazo) resorcinolato chelates" Journal of Chromatography. A., 772. 339-346 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Hattori: "Highly Stereospecific Conversion of Planar Chirality of a Cyclophane into Axial Chirality of Binaphthyls" Tetrahedron Lett.37, (12). 2057-2060 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kumagai: "Facile Synthesis of p-tert-butylthiacalix [4] arene by the reaction of p-tert-butyl-phenol with elemental sulfur in the presence of a base" Tetrahedron Lett.38, No.22. 3971-3972 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "High Complexation Ability of Thiacalixarene to Transition Metal Ions. The Effect of Replacing Methylene Bridges of Tetra (p-t-butyl) calix [4] arenetetrol by Epithio Groups" Bull.Chem.Soc.Jpn.71 (7). 1597-1603 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "Selective Oxidation of Thiacalix [4] arenes to the Sulfinyl-and Sulfonylcalix [4] arenes and Their Coordination Ability to Metal Ions." Tetrahedron Lett.39 (41). 7559-7562 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "Selective Synthesis of Three Different Isomers of Tetrakis [(ethoxycarbonyl) methoxy] -thiacalix [4] -arene and Their Complexation Properties Towards Alkali Metal Ions" Journal of the Chemical Society, Perkin Trans. 2. 2745-2750 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] E.Broclawik: "On the Electronic Structure of the Palladium Monoxide and the Methane Adsorption : Density Functional Calculations" The Journal of Chemical Physics. 104. 4098-4104 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Oumi: "The Structure and Electronic Characteristics of Metallosilicates with ZSM-5 Structure" Catal.Lett.45. 21-26 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Sato: "Molecular Dynamics Simulation of Metal Porphyrin Complex Encapsulated in Zeolite" Appl.Surf.Sci.346 (350). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.Chatterjee: "Application of Integrated Computer Simulation Approach to Solid Surfaces and Interfaces" Catalysis Surveys from Japan. 2. 133-154 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Sato: "The Dynamics Study of Metallocene Catalyst Using Molecular Dynamics" Applied Surface Science. 130-132. 501-505 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.Yamada: "Tight-binding Molecular Dynamics Simulation of Desorbed SiO Molecule during the Oxidation of Si (111) Surface" Japanese Journal of Applied Physics. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] N.Iki: "High Complexation Ability of Thiacaliarene to Transition Metal Ions.The Effect of Replacing Methylene Bridges of Tetra(p-t-butyl)calix[4]arenetetrol by Epithio Groups" Bull.Chem.Soc.Jpn.71・7. 1597-1603 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Iki: "Selective Oxidation of Thiacalix[4]arenes to the Sulfinyl-and Sulfonylcalix[4]arenes and Their Coordination Ability to Metal Ions" Tetrahedron Lett.39・41. 7559-7562 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Iki: "Selective Synthesis of Three Different Isomers of Tetrakis[(ethoxycarbonyl)methoxy]-thiacalix[4]-arene and Their complexation Properties Towards Alkali Metal Ions" J.Chem.Soc., Perkin Trans.2. 12. 2745-2750 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abhijit Chatterjee: "Application of Integrated Computer Simulation Approach to Solid Surface and Interfaces" Catalysis Sureveys from Japan. 2. 133-154 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takeshi Sato: "The Dynamics Study of Metallocene Catalyst Using Molecular Dynamics" Applied Surface Science. 130 132. 501-505 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aruba Yamada: "Tight-binding Molecular Dynamics Simulation of Desorbed SiO Molecule during the Oxidation of Si(111)Surface" Japanese Journal of Applied Physics,. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Oleg V.Krokhin: "Use of Cationic polymers for simultaneous determination of inorganic anion and metal-4-(2-pyridylazo)resorcinolato chelates in kinetic differentiation-mode capillary electrophoresis" Journal of Chromatography. 776. 329-336 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oleg V.Krokhin: "Influence of cationic polymers on separation selectivity in kinetic differentiation mode capillary electrophoresis of metal-4-(2-pyridylazo)resorcinolato chelates" Journal of Chromatography. 772. 339-346 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 鈴木 俊夫: "キャピラリー電気泳動法によるフミン物質のキャラクタリゼーション" 分析化学. 46. 477-482 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Sato,: "Molecular Dynamics Simulation of Metal Porphyrin Complex Encapsulated in Zeolite" Applied Surface Science. 119. 346-350 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Endou: "Adsorption of NO on Rhodium and Palladium Clusters : A Density Functional Study" Applied Surface Science. 119. 318-320 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] E.Broclawik: "Electronic Structure and Adsorption Properties of Precious Metals and Their Oxides : Density Functional Calculations" Journal of Molecular Catalysis. A119. 35-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Miyano: "Facile Synthesis of p-tert-Butylthiacalix[4]arene by the Reaction of p-tert-Butylphenol with Elemental Sulfur in the Presence of a Base" Tetrahedron Lett.,. 38(22). 3971-3972 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Miyano: "Ester-Mediated Nucleophilic Aromatic Substitution of 2,3-Alkylidenedioxybenzoic Esters by Aryl Lithium Reagents" Chem.Lett.,. 1997(7). 641-642 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Miyano: "Chelation-assisted Nucleophilic Aromatic Substitution of 2-Sulfonyl-substituted 1-Meth-oxynaphthalenes by Grignard Reagents" J.Chem.Soc.,Perkin Trans.1,. 1997(4). 1117-1123 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Miyano: "Synthesis of Chiral Aminophosphines via Nucleophilic Aromatic Substitution and Their Application to Palladium-Catalyzed Allylic Substitution" Enantiomer,. 2(3/4). 203-213 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 宮本明: "環境触媒ー実際と展望ー" 共立出版, 112 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oleg V. Krokhin: "Simultaneous Determination of Inorganic Anions and Equally Charged Complexes of Transition Metals with Polyminocarboxylic Acids by Capillary Electrophoresis." Chem. istry Letters. 1095-1096 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nobuhiko Iki: "High-Performance Liquid Chromatographic Methods for Monitoring of Nickel and Vanadium in Air at the Nanogram per Cubic Meter Levels." Environmental Science and Technology. 31. 12-16 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tetsutaro Hattori: "Highly Stereospecific Conversion of Planar Chirality of a Cyclophane into Axial Chirality of Binaphthyls." Tetrahedron Letters. 37. 2057-2060 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ewa Broclawik: "On the Electronic Structure of the Palladium Monoxide and the Methane Adsorption Density Functional Calculations" The Journal of Chemical Physics. 104. 4098-4104 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ewa Broclawik: "Density Functional Theory as a Tool in Studying Catalytic Processes" Theoretical and Computational Chemostry. 3 (in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-03-31   Modified: 2016-04-21  

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