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Morphological and molecular cell biology studies on aging changes and reconstruction of bone tissue.

Research Project

Project/Area Number 08407056
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

OZAWA Hidehiro  Niigata University, School of Dentisty, Professor, 歯学部, 教授 (60018413)

Co-Investigator(Kenkyū-buntansha) AMIZUKA Norio  Niigata University, School of Dentisty, Research, Associate, 歯学部, 助手 (30242431)
NAKAMURA Hiroaki  Niigata University, School of Dentisty, Research, Associate, 歯学部, 助手 (50227930)
IRIE Kazuharu  Niigata University, School of Dentisty, Research Associate, 歯学部, 助手 (70223352)
EJIRI Sadakazu  Niigata University, School of Dentisty, Associate Professor, 歯学部, 助教授 (40160361)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥29,300,000 (Direct Cost: ¥29,300,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1997: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1996: ¥21,700,000 (Direct Cost: ¥21,700,000)
KeywordsBone Tissue / Aging / Bone Reconstruction / Bone Morphometry / Histochemistry / Molecular and Cell Biology / PTH / BMP / 顎骨 / 骨粗鬆症 / 骨形態計測 / μCT / PTHrPレセプター / 脊柱靭帯骨化症 / メカニカルストレス / 加齢 / 卵巣摘出 / 骨形成誘導因子 / インプラント / 骨形態測定 / 細胞基質間認識 / In situハイブリダイゼーション / 遺伝子発現
Research Abstract

[Studies on aging in bone tissue using new bone morphometrical methods] In order to establish the basic system for the research on aging phenomena in the jaw bone, we developed a new morphometrical method using confocal laser microscope and applied muCT on the bone morphometrical studies. From the results using the system, it is demonstrated that the bone loss occurred in mandibular condyle following estrogen deficiency and the condyle maintained the bone mass with dynamic structural alterations, due to regionally different reactivity against estrogen deficiency and the bone formative stimulus by occlusal force. [Histochemical studies on aging bones] With advancing age, the mandibular chondylar cartilage, which produced type II collagen fibers, became fibrocartilage-like tissue which produced type I collagen fibers. Hypertrophic chondrocytes in the condyle disappeared in the course of aging. Adipocytes were found prominently in the bone marrow of aged rat. From these results, it is sug … More gested that aging phenomena in bone tissue occurred through the control mechanisms in proliferation and differentiation of chondrocytes, osteoblasts and osteoclasts. [Molecular and cell biological studies on aging bones] Using the in situ hybridization method, we assessed the changing of the gene expression patterns in bone tissue with advancing age. In bones of OVX rats and PTHrP gene-knock out mice, gene expression patterns of osteonectin, ALPase, PTHrP, FGF and their receptor were suppressed in the course of aging. Gene expression patterns in bones with advancing age may change in association with the suppression of cell differentiation. [Inducing bone experiments] In order to prevent and recover the bone loss which occurred with aging, we assessed the effects of intermittent administration of PTH and implantation of BMP-2 pellets on mandibles of experimental animals. The preventive and therapeutic intermittent administrations of PTH in ovariectomized rats increased the bone formation in rat mandibular condyle without accelerating bone resorptive activity. When BMP-2 pellets were implanted into the extracted teeth cavities, proliferation of mesenchymal cells and differentiation of preosteoblasts into osteoblasts were induced and rapid bone formation occurred in the cavities. Furthermore, application of e-PTFE membrane after the implantation of BMP-2 pellets was effective to form the new bone into the designed bone shape. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (214 results)

All Other

All Publications (214 results)

  • [Publications] Hiraga,T.他: "Inhibitory effects of bisphosphonate(YM175)on bone resorption induced by a metastatic bone tumor." Bone. 18・1. 1-8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hara,F.他: "Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs." Bone. 18・1. 29-39 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Irie,K.他: "Immunohistochemical localization of parathyroid hormone/parathyroid hormone-related peptide receptor in rat tibiae." Journal of Bone and Mineral Metabolism. 14・1. 10-24 (1996)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura,H.他: "Ultrastructural,eyzyme,lectin and immunohistochemical studies of the erosion zone in rat tibiae." Journal of Bone and Mineral Research. 11・8. 1158-1164 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiba,N.他: "Immunohistochemical localization of HLA-DR positive cells in the unerupted and erupted normal and carious human teeth." Journal of Dental Research. 75・8. 1585-1589 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiba,K.他: "Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide." Journal of Dental Research. 75・8. 1590-1597 (1996)

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      1998 Final Research Report Summary
  • [Publications] Amizuka,N.他: "Haploinsufficiency of parathyroid hormone-related peptide(PTHrP)results in abnormal post-natal bone development:Analysis of mice heterozygous for PTHrP gene ablation." Development Biology. 175・1. 166-176 (1996)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Sato,K.他: "17 β-Estradiol increases calcium content in fetal parietal bones cultured in serum-free medium only at physiological concentrations." Bone. 19・3. 213-221 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田中みか子 他: "卵巣摘出が成熟ラット下顎関節突起に及ぼす影響に関する軟X線写真画像解析" 日本補綴歯科学会雑誌. 40・4. 188-193 (1996)

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      1998 Final Research Report Summary
  • [Publications] Iguchi, H.他: "An experimental model of bone metastasis by human lung cancer cells : The role of parathyroid" Cancer research 56. 56. 4040-4043 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura H.他: "Immunolocalization of CD44 and ERM family in osteoblasts and osteoclasts in mouse tibiae." Journal of Bone and Mineral Research. 11・11. 1715-1722 (1996)

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      1998 Final Research Report Summary
  • [Publications] Alpaslan C.他: "Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system." British Journal of Oral and Maxillofacial Surgery. 34. 414-418 (1996)

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      1998 Final Research Report Summary
  • [Publications] Kabasawa, M.他: "Effect of age on physiological and mechanically-stressed alveolar bone-a cytological and histochemical study-" International Journal of Adult Orthodontics and Orthognathic Surgery. 11・4. 313-327 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kazama, JJ.他: "24R, 25-dehydroxyvitamin D3 ameliorates the high-turnover bone diseases without suppressing parathyroid function in chronic renal failure in rats." Nephrology. 2. 36 (1996)

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      1998 Final Research Report Summary
  • [Publications] Amizuka, N.他: "The biological action of parathyroid hormone-related peptide on bone cells." Tissue Engineering. 2・4. 277-287 (1996)

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      1998 Final Research Report Summary
  • [Publications] Amizuka, N.他: "Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide(PTHrP)gene deletion." Endocrinology. 137・11. 5055-5067 (1996)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga, T.他: "Effects of bisphosphonate(pamidronate)on bone resorption resulting from metastases of a human squamous cell carcinoma.-Report of an Autopsy Case and Evaluation of Bone Resorbing Activity by Animal Experimental Model-" Journal of Oral Maxillofacial Surgery. 54. 1327-1333 (1996)

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      1998 Final Research Report Summary
  • [Publications] Hamamoto, Y.他: "Production of amelogenin by enamel epithelium of Hertwig′s root sheath." Oral Surg.Med.Oral Pathol.Oral Radiol.Endod.81. 703-709 (1996)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] 江尻貞一 他: "骨組織の動態観察" 細胞工学. 15・3. 358-364 (1996)

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      1998 Final Research Report Summary
  • [Publications] 網塚憲生 他: "副甲状腺ホルモン関連ペプチド遺伝子ノックアウトマウスとレセプターの新しい研究展開" 実験医学. 14・10. 190-196 (1996)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨 : 骨形成" 生体の科学. 47・5. 510-515 (1996)

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      1998 Final Research Report Summary
  • [Publications] 平賀 徹 他: "骨転移の微細構造" THE BONE. 10・3. 53-61 (1996)

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      1998 Final Research Report Summary
  • [Publications] 中村浩彰 他: "共焦点走査型レーザー顕微鏡の硬組織分野への応用" 細胞. 28・9. 8-13 (1996)

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      1998 Final Research Report Summary
  • [Publications] 中村浩彰 他: "骨改造現象と細胞連関" 日本整形外科学雑誌. 70・11. 740-750 (1996)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.他: "Cell-specific expression of the parathyroid hormone/(PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters." Endocrinology. 138・1. 469-481 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato,K.他: "Saccharated ferric oxide(SFO)-induced osteomalacia : In vitro inhibition by SFO of bone formation and 1, 25-dihyroxy-vitamin D production in renal tubules." Bone. 21・1. 57-64 (1997)

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      1998 Final Research Report Summary
  • [Publications] Rakiba,S.他: "Histochemical study of alveolar bone remodeling in op/op mice by the administration of macrophage-colony stimulating factor." Journal of Bone and Mineral Metabolism. 15・2. 59-66 (1997)

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      1998 Final Research Report Summary
  • [Publications] Tanaka, M.他: "Histochemical examination of ectopic bone formation induced in rat bone marrow." Journal of Bone and Mineral Metabolism. 15・2. 67-76 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohashi, N.他: "Changes in type I, II and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model." Journal of Bone and Mineral Metabolism. 15・2. 77-83 (1997)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Hoshi, K.他: "Immunolocalization of tissue non-specific alkaline phosphatase in mice." Histochemistry and Cell Biology. 107. 183-191 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, H.他: "Immunolocalization of CD44 and the ezrin-radixin-moesin(ERM)family in the stratum intermedium and papillary layer of the mouse enamel organ." Journal of Histochemistry and Cytochemistry. 45・11. 1481-1492 (1997)

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      1998 Final Research Report Summary
  • [Publications] Hoshi, K.他: "Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2 : Morphological examinations for ossification of spinal ligaments." Bone. 21・2. 155-162 (1997)

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      1998 Final Research Report Summary
  • [Publications] Amizuka, N.他: "An Ultrastructural study of cell-cell contact between mouse spleen cells and calvaria-derived osteoblastic cells in a co-culture system for osteoclast formation." Acta Histochemistry and Cytochemistry. 30・4. 351-362 (1997)

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      1998 Final Research Report Summary
  • [Publications] Nakamura, H.他: "The Localization of CD44 and Moesin in Osteoclasts after Calcitonin Administration in Mouse Tibiae." Journal of Bone and Mineral Metabolism. 15. 184-192 (1997)

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      1998 Final Research Report Summary
  • [Publications] Hoshi, K.他: "Ultrastructure and immunolocalization of transforming growth factor-beta in chondrification of murine ligamentous fibroblasts and endochondral calcification induced by recombinant human bone morphogenetic protein-2." Acta Histochemistry and Cytochemistry. 30・4. 371-379 (1997)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Nakamura, H.他: "CD44 and the ERM family in bone cells." Acta Histochemistry and Cytochemistry. 30・2. 125-134 (1997)

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      1998 Final Research Report Summary
  • [Publications] 網塚憲生 他: "軟骨と骨組織におけるアポトーシス" 現代医療. 29・1. 171-180 (1997)

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      1998 Final Research Report Summary
  • [Publications] 網塚憲生 他: "軟骨の分化増殖における形態学的、細胞生物的知見" THE BONE. 11・3. 39-52 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨組織の微細構造と機能に関する最近の知見" 日本界面医学界雑誌. 28. 1-12 (1997)

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      1998 Final Research Report Summary
  • [Publications] 網塚憲生 他: "骨と腎ではPTH/PTHrPレセプターの遺伝子発現は異なるプロモーター領域で調節される" 日本骨代謝学会雑誌. 15・1. 1-7 (1997)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga, T.他: "Morphology of bone metastasis." European Journal of Cancer. 34・2. 230-239 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kameda, T.他: "Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells." Biochemical and Biophysical Research Communications. 245. 419-422 (1998)

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      1998 Final Research Report Summary
  • [Publications] Beck, L.他: "Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities." Proceedings of the National Academy of Science of the United States of America. 95. 5372-5377 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kabasawa, Y.他: "Immunoreactive localization of transforming growth factor-β type II receptor-positive cells in rat tibiae." Bone. 22・2. 93-98 (1998)

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      1998 Final Research Report Summary
  • [Publications] Mizuno, A.他: "Swvere osteoporosis in mice lacking OCIF/OPG(Osteoclastogenesis inhibitory factor/Osteoprotegerin)." Biochemical and Biophysical Research Communications. 247. 610-615 (1998)

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      1998 Final Research Report Summary
  • [Publications] Amizuka, N.他: "Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow." Microscopy Research and Technique. 41. 313-322 (1998)

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      1998 Final Research Report Summary
  • [Publications] Fukushi, M.他: "Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a gly317 asp substitution associated with lethal hypophosphatasia." Biochemical and Biophysical Research Communications. 246. 613-618 (1998)

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      1998 Final Research Report Summary
  • [Publications] Tanaka, M.他: "The effect of aging and ovariectomy on mandibular condyle in rats." The Journal of Prosthetic Dentistry. 79・6. 685-690 (1998)

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      1998 Final Research Report Summary
  • [Publications] Ueda, J.他: "Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of india ink." Japan Journal of Ophthalmology. 42. 337-344 (1998)

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      1998 Final Research Report Summary
  • [Publications] 上田 潤 他: "墨汁の前房内注入と隅角光凝固によるラット緑内障モデルの作製" 日本眼科学会雑誌. 102・4. 239-246 (1998)

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      1998 Final Research Report Summary
  • [Publications] Yoshiba, N.他: "Immunohistochemical localizations of class II antigens and nerve fibers in human carious teeth : HLA-DR immunoreactivity in schwann cells." Archives of Histology and Cytology. 61・4. 343-352 (1998)

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      1998 Final Research Report Summary
  • [Publications] Tanaka, Y.他: "Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cells." Cancer Research. 58. 4138-4145 (1998)

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      1998 Final Research Report Summary
  • [Publications] Hamamoto, Y.他: "Morphological changes of epithelial rests of Malassez in rat molars induced by local administration of N-methylnitrosourea." Archives of Oral Biology. 43. 899-906 (1998)

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      1998 Final Research Report Summary
  • [Publications] Irie, K.他: "Morphological and immunocytochemical characterization of primary osteogenic cell cultures derived from fetal rat cranial tissue." Anatomical Record. 255. 554-567 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "インプラント周囲骨の再生-微細構造学的にみた骨代謝-" 日本歯科医学会誌. 17. 130-133 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 1.骨のリモデリングのメカニズム" クインテッセンス・デンタル・インプラントロジー. 5・1. 73-75 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 2.骨の基本構造" クインテッセンス・デンタル・インプラントロジー. 5・2. 68-72 (1998)

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      1998 Final Research Report Summary
  • [Publications] 平賀 徹 他: "癌の骨転移病巣の組織像" CLINICAL CALCIUM. 8・3. 98-100 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 3.骨の細胞たち" クインテッセンス・デンタル・インプラントロジー. 5・3. 48-50 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨改造現象の形態学" 日本臨牀. 56・6. 24-41 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 4.骨の細胞たち-II" クインテッセンス・デンタル・インプラントロジー. 5・4. 78-83 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨改造現象の微細形態学的見解" 日本補綴歯科学会雑誌. 42・3. 359-368 (1998)

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      1998 Final Research Report Summary
  • [Publications] 濱本宜興 他: "マラッセの上皮遺残の臨床的役割" ザ・クインテッセンス. 17・5. 3-12 (1998)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨芽細胞と破骨細胞の超微細構造と機能" 実験医学. 16・1. 96-107 (1998)

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      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] 平賀 徹 他: "骨転移巣の微細形態" 病理と臨床. 17・1. 39-42 (1998)

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      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨の構造と機能 1-骨の基本構造と骨形成系細胞-" 歯界展望. 92・5. 1123-1136 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨の構造と機能(2)-骨吸収破骨細胞-" 歯界展望. 92・6. 1377-1392 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 5.骨の細胞たち-III" クインテッセンス・デンタル・インプラントロジー. 5・5. 70-74 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "破骨細胞におけるカルシトニンのカルシトニンレセプターへの作用" Osteoporosis Japan. 6・2. 143-148 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨・基礎講座 6.骨の細胞たち-IV" クインテッセンス・デンタル・インプラントロジー. 5・6. 62-69 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 樺澤裕未 他: "成長期ラット脛骨におけるTGF-βII型レセプターの局在と遺伝子発現の検討" 新潟歯学会雑誌. 28・1. 81-82 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 大橋直子 他: "成長ラット下顎頭軟骨の加齢に伴うI, II, Xコラーゲンの局在変化に関する免疫組織化学的研究" 新潟歯学会雑誌. 28・1. 85-86 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 泉 直也 他: "電子顕微鏡観察のための硬組織迅速脱灰法" 電子顕微鏡. 33・3. 202-204 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karaplis A.他: "Blomstrand chondrodisplasia caused by a missense mutation in the human parathyroid hormone receptor-1." Endocrinology. 139・12. 5255-5258 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka N.他: "Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage." Journal of Clinical Investigation. 103・3. 373-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi K.他: "The primary calcification in bones follows removal of decorin and fusion collagen fibrils." Journal of Bone and Mineral Research. 14・2. 273-280 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 平賀 徹 他: "癌の骨転移の微細形態" 腎と骨代謝. 12・1. 15-21 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "骨の微細構造" 月刊ザ・クインテッセンス. 18・1. 176-185 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Horiuchi K.他: "Identification and Characterization of a novel protein, Periostin(OSF-2)with restricted expression to periosteum and periodontal ligament and increased expression by transforming factor." Journal of Bone and Mineral Research. in press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi K.他: "Histopathological Characterization of Melorheostosis." Orthopedics. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "解剖学者が語る人体の世界" 風人社, 237 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "かむこと、のむこと、たべること-咀嚼の科学-" 医歯薬出版, 270 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩他: "分子骨代謝学と骨粗鬆症" メディカルレビュー社, 405 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 中村浩彰: "骨シグナルと骨粗鬆症" 羊土社, 108 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "カルシウムと骨代謝-最近の進歩-" 雪印株式会社健康生活研究所, 285 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "プラクティカル内科シリーズ4.骨粗鬆症" 南江堂, 230 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 網塚憲生 他: "カルシトニン-基礎と臨床-" ライフサイエンス出版, 235 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 池亀美華 他: "カルシトニン-基礎と臨床-" ライフサイエンス出版, 235 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小澤英浩: "最新骨粗鬆症" ライフサイエンス出版 (印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga, T.et al.: "Inhibitory effects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor." Bone. 18 (1). 1-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hara, F.et al.: "Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs." Bone. 18 (1). 29-39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Irie, K.et al.: "Immunohistochemical localization of parathyroid hormone/parathyroid hormone-related peptide receptor in rat tibiae." Journal of Bone and Mineral Metabolism. 14 (1). 10-14 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, H.et al.: "Ultrasturctural, enzyme, lectin and immunohistochemical studies of the erosion zone in rat tibiae." Journal of Bone and Mineral Research. 11 (8). 1158-1164 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiba, N.et al.: "Immunohistochemical localization of HLA-DR positive cells in the unerupted and erupted normal and carious human teeth." Journal of Dental Research. 75 (8). 1585-1589 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiba, K.et al.: "Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide." Journal of Dental Research. 75 (8). 1590-1597 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal post-natal bone development : Analysis of mice heterozygous for PTHrP gene ablation." Development Biology. 166-176 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato, K.et al.: "17beta-Estradiol increases calcium content in fetal parietal bones cultured in serum-free medium only at physiological concentrations." Bone. 19 (3). 213-221 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Iguchi, H.et al.: "An experimental model of bone metastasis by human lung cancer cells : The role of parathyroid hormone-related protein in bone metastasis." Cancer research. 56. 4040-4043 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura H.et al.: "Immunolocalization of CD44 and ERM family in osteoblasts and osteoclasts in mouse tibiae." Journal of Bone and Mineral Research. 11 (11). 1715-1722 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Alpaslan C.et al.: "Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system." British Journal of Oral and Maxillofacial Surgery. 34. 414-418 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kabasawa, M.et al.: "Effect of age on physiological and mechanically-stressed rat alveolar bone-a cytological and histochemical study-" International Journal of Adult Orthodontics and Orthognathic Surgery. 11 (4). 313-327 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kazama, J.J.et al.: "24R,25-dehydroxyvitamin D3 ameliorates the high-turnover bone diseases without suppressing parathyroid function in chronic renal failure in rats." Nephrology. 2. 361-366 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "The biological action of parathyroid hormone-related peptide on bone cells." Tissue Engineering. 2 (4). 277-287 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide (PTHrP) gene diletion." Endocrinology. 137 (11). 5055-5067 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga, T.et al.: "Effects of bisphosphonate (pamidronate) on bone resorption resulting from metastases of a humansquamous cell carcinoma. -Report of an Autopsy Case and Evaluation of Bone Resorbing Activity by Animal Experimental Model-" Journal of Oral Maxillofacial Surgery. 54. 1327-1333 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hamamoto, Y.et al.: "Production of amelogenin by enamel epithelium of Hertwig's root sheath." Oral Surg.Med.Oral Pathol.Oral Radiol.Endod.81. 703-709 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "Cell-specific expression of the parathyroid hormone/(PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters." Endocrinology. 138 (1). 469-481 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato, K.et al.: "Saccharated ferric oxide (SFO) -induced osteomalacia : In vitro inhibition by SFO of bone formation and 1,25-dihydroxy-vitamin D production in renal tubules." Bone. 21 (1). 57-64 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Rakiba, S.et al.: "Histochemical study of alveolar bone remodeling in op/op mice by the administration of macrophage-colony stimulating factor." Journal of Bone and Mineral Metabolism. 15 (2). 59-66 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka, M.et al.: "Histochemical examination of ectopic bone formation induced in rat bone marrow." Journal of Bone and Mineral Metabolism. 15 (2). 67-76 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohashi, N.et al.: "Changes in type I,II and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model." Journal of Bone and Mineral Metabolism. 15 (2). 77-83 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi, K.et al.: "Immunolocalization of tissue non-specific alkaline phosphatase in mice." Histochemistry and Cell Biology. 107. 183-191 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, H.et al.: "Immunolocalization of CD44 and the ezrin-radixin-moesin (ERM) family in the stratum intermedium and papillary layer of the mouse enamel organ." Journal of Histochemistry and Cytochemistry. 45 (11). 1481-1492 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi, K.et al.: "Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2 : Morphological examinations for ossification of spinal ligaments." Bone. 21 (2). 155-162 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "An Ultrastructural study of cell-cell contact between mouse spleen cells and calvaria-derived osteoblastic cells in a co-culture system for osteoclast formation." Acta Histochemistry and Cytochemistry. 30 (4). 351-362 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, H.et al.: "The Localization of CD44 and Moesin in Osteoclasts after Calcitonin Administration in Mouse Tibiae." Journal of Bone and Mineral Metabolism. 15. 184-192 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi, K.et al.: "Ultrastructure and immunolocalization of transforming growth factor-beta in chondrification of murine ligamentous fibroblasts and endochondral calcification induced by recombinant human bone morphogenetic protein-2." Acta Histochemistry and Cytochemistry. 30 (4). 371-379 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakamura, H.et al.: "CD44 and the ERM family in bone cells." Acta Histochemistry and Cytochemistry. 30 (2). 125-134 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga, T.et al.: "Morphology of bone metastasis." European Journal of Cancer. 34 (2). 230-239 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kameda, T.et al.: "Calcium-sensing receptor in mature osteoclasts, which at bone resorbing cells." Biochemical and Biophysical Research Communications. 245. 419-422 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Beck, L.et al.: "Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities." Proceedings of the National Academy of Science of the United States of America. 95. 5372-5377 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kabasawa, Y.et al.: "Immunoreactive localization of transforming growth factor-beta tyep II receptor-positive cells in rat tibiae." Bone. 22 (2). 93-98 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mizuno, A.et al.: "Swvere osteoporosis in mice lacking OCIF/OPG (Osteoclastogenesis inhibitory factor/Osteoprotegerin)." Biochemical and Biophysical Research Communications. 247. 610-615 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka, N.et al.: "Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow." Microscopy Research and Technique. 41. 313-322 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukushi, M.et al.: "Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a gly317 asp substitution associated with lethal hypophosphatasia." Biochemical and Biophysical Research Communications. 246. 613-618 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka, M.et al.: "The effect of aging and ovariectomy on mandibular condyle in rats." The Journal of Prosthetic Dentistry. 79 (6). 685-690 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ueda, J.et al.: "Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of india ink." Japan Journal of Ophthalmology. 42. 377-344 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshiba, N.et al.: "Immunohistochemical localizations of class II antigens and nerve fibers in human carious teeth : HLA-DR immunoreactivity in schwann cells." Archives of Histology and Cytology. 61 (4). 343-352 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka, Y.et al.: "Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cells." Cancer Research. 58. 4138-4145 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hamamoto, Y.et al.: "Morphological changes of epithelial rests of Malassez in rat molars induced by local administration of N-methylnitrosourea." Archives of Oral Biology. 43. 899-906 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Irie, K.et al.: "Morphological and immunocytochemical characterization of primary osteogenic cell cultures derived from fetal rat cranial tissue." Anatomical Record. 252. 554-567 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karaplis A.et al.: "Blomstrand chondrodisplasia caused by a missense mutation in the human parathyroid hormone receptor-1." Endocrinology. 139 (12). 5255-5258 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Amizuka N.et al.: "Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage." Journal of Clinical Investigation. 103 (3). 373-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi K.et al.: "The Primary calcification in bones follows removal of decorin and fusion of collagen fibrils." Journal of Bone and Mineral Research. 14 (2). 273-280 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Horiuchi K.et al.: "Identification and Characterization of a novel protein, Periostin (OSF-2) with restricted expression to periosteum and periodontal ligament and increased expression by transforming factor." Journal of Bone and Mineral Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hoshi K.et al.: "Histopathological Characterization of Melorheostosis." Orthopedics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiraga,T.他: "Morphology of bone metastasis." European Journal of Cancer. 34・2. 230-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kameda,T.他: "Calcium-sensing receptor in mature osteoclasts,which are bone resorbing cells." Biochemical and Biophysical Research Communications. 245. 419-422 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Beck,L.他: "Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting,hypercalciuria,and skeletal abnormalities." Proceedings of the National Academy of Science of the United States of America. 95. 5372-5377 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kabasawa,Y.他: "Immunoreactive localization of transforming growth factor-β type II receptor-positive cells in rat tibiae." Bone. 22・2. 93-98 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizuno,A.他: "Swvere osteoporosis in mice lacking OCIF/OPG(Osteoclastogenesis inhibitory factor/Osteoprotegerin)." Biochemical and Biophysical Research Communications. 247. 610-615 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Amizuka,N.他: "Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow." Microscopy Research and Technique. 41. 313-322 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukushi,M.他: "Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a gly317 asp substitution associated with lethal hypophosphatasia." Biochemical and Biophysical Research Communications. 246. 613-618 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,M.他: "The effect of aging and ovariectomy on mandibular condyle in rats." The Journal of Prosthetic Dentistry. 79・6. 685-690 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ueda,J.他: "Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of india ink." Japan Journal of Ophthalmology. 42. 337-344 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上田 潤 他: "墨汁の前房内注入と隅角光凝固によるラット緑内障モデルの作製" 日本眼科学会雑誌. 102・4. 239-246 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshiba,N.他: "Immunohistochemical localizations of class II antigens and nerve fibers in human carious teeth:HLA-DA immunoreactivity in schwann cells." Archives of Histology and Cytology. 61・4. 343-352 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,Y.他: "Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cells." Cancer Research. 58. 4138-4145 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hamamoto,Y.他: "Morphological changes of epithelial rests of Malassez in rat molars induced by local administration of N-methylnitrosourea." Archives of Oral Biology. 43. 899-906 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Irei,K.他: "Morphological and immunocytochemical characterization of primary osteogenic cell cultures derived from fetal rat cranial tissue." Anatomical Record. 252. 554-567 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "インプラント周囲骨の再生ー微細構造学的にみた骨代謝ー" 日本歯科医学会誌. 17. 130-133 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 1.骨のリモデリングのメカニズム" クインテッセンス・デンタル・インプラントロジー. 5・1. 73-75 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 2.骨の基本構造" クインテッセンス・デンタル・インプラントロジー. 5・2. 68-72 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 平賀 徹 他: "癌の骨転移病巣の組織像" CLINICAL CALCIUM. 8・3. 98-100 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 3.骨の細胞たち" クインテッセンス・デンタル・インプラントロジー. 5・3. 48-50 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨改造現象の形態学" 日本臨牀. 56・6. 24-41 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 4.骨の細胞たちーII" クインテッセンス・デンタル・インプラントロジー. 5・4. 78-83 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨改造現象の微細形態学的見解" 日本補綴歯科学会雑誌. 42・3. 359-368 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 濱本宜興 他: "マラッセの上皮遺残の臨床的役割" ザ・クインテッセンス. 17・5. 3-12 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨芽細胞と破骨細胞の超微細構造と機能" 実験医学. 16・1. 96-107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 平賀 徹 他: "骨転移巣の微細形態" 病理と臨床. 17・1. 39-42 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨の構造と機能 1-骨の基本構造と骨形成系細胞ー" 歯界展望. 92・5. 1123-1136 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨の構造と機能(2)ー骨吸収と破骨細胞ー" 歯界展望. 92・6. 1377-1392 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 5.骨の細胞たちーIII" クインテッセンス・デンタル・インプラントロジー. 5・5. 70-74 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "破骨細胞におけるカルシトニンのカルシトニンレセプターへの作用" Osteoporosis Japan. 6・2. 143-148 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨・基礎講座 6.骨の細胞たちーIV" クインテッセンス・デンタル・インプラントロジー. 5・6. 62-69 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 樺澤裕未 他: "成長期ラット脛骨におけるTGF-βII型レセプターの局在と遺伝子発現の検討" 新潟歯学会雑誌. 28・1. 81-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大橋直子 他: "成長ラット下顎頭軟骨の加齢に伴うI,II,Xコラーゲンの局在変化に関する免疫組織化学的研究" 新潟歯学会雑誌. 28・1. 85-86 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 泉 直也 他: "電子顕微鏡観察のための硬組織迅速脱灰法" 電子顕微鏡. 33・3. 202-204 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Karaplis A.他: "Blomstrand chondrodisplasia caused by a missense mutation in the human parathyroid hormone receptor-1." Endocrinology. 139・12. 5255-5258 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Amizuka N.他: "Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage." Journal of Clinical Investigation. 103・3. 373-381 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hoshi K.他: "The Primary calcification in bones follows removal of decorin and fusion of collagen fibrils." Journal of Bone and Mineral Research. 14・2. 273-280 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 平賀 徹 他: "癌の骨転移の微細形態" 腎と骨代謝. 12・1. 15-21 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "骨の微細構造" 月刊ザ・クインテッセンス. 18・1. 176-185 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Horiuchi K.他: "Identification and Characterization of a novel protein,Periostin(OSF-2)with restricted expression to periosteum and periodontal ligament and increased expression by transforming factor." Journal of Bone and Mineral Research. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Hoshi K.他: "Histopathological Characterization of Melorheostosis." Orthopedics. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "カルシウムと骨代謝ー最近の進歩ー" 雪印株式会社健康生活研究所, 285 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "プラクティカル内科シリーズ4.骨粗鬆症" 南江堂, 230 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 網塚憲生 他: "カルシトニンー基礎と臨床ー" ライフサイエンス出版, 235 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 池亀美華 他: "カルシトニンー基礎と臨床ー" ライフサイエンス出版, 235 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小澤英浩: "最新骨粗鬆症" ライフサイエンス出版(印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] Amizuka,N., 他: "Cell - specific expression of the parathyroid hormone / (PTH) / PTH - related peptide receptor gene in kidney from kidney - specific and ubiquitous promoters." Endocrinology. 138・1. 469-481 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Rakiba,S., 他: "Histochemical study of alveolar bone remodeling in op / op mice by the administration of macrophage - colony stimulating factor." J. Bone Miner. Metab.15・2. 59-66 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka,M., 他: "Histochemical examination of ectopic bone formation induced in rat bone marrow." J. Bone Miner. Metab.15・2. 67-76 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohashi,N., 他: "Changes in type I, ・・ and X collagen immunoreacitivity of the mandibular condylar cartilage in a naturally aging rat model." J. Bone Miner. Metab.15・2. 77-83 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshi,K., 他: "Immunolocalization of tissue non - specific alkaline phosphatase in mice." Histochem. Cell Biol.107. 183-191 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura,H., 他: "Immunolocalization of CD44 and the ezrin - radixin - moesin (ERM) family in the stratum intermedium and papillary of the mouse enamel organ." J. Histochem. Cytochem.45・11. 1481-1492 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshi,K., 他: "Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein - 2 : Morphological examinations for ossification of spinal ligaments." Bone. 21・2. 155-162 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amizuka,N., 他: "An Ultrastructural study of cell - cell contact between mouse spleen cells and calvaria - derived osteoblastic cells in a co - culture system for osteoclast formation." Acta Histochem. Cytochem.30・4. 351-362 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura,H., 他: "The Localization of CD44 and Moesin in Osteoclasts after Calcitonin Administration in Mouse Tibiae." J. Bone Miner. Metab.15. 184-192 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshi,K., 他: "Ultrastruccture and immunolocalization of transforming grouwth factor - β in chondrification of murine ligamentous fibroblasts and endochondral calcification induced by recombinant human bone morphogenetle protein - 2." Acta Histochem. Cytochem.30・4. 371-379 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura,H., 他: "CD44 and the ERM family in bone cells." Acta Histochem. Cytochem.30・2. 125-134 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 網塚憲生, 他: "軟骨の分化増殖における形態学的、細胞生物学的知見" THE BONE. 11・3. 39-52 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小澤英浩, 他: "骨組織の微細構造と機能に関する最近の知見" 日本界面医学会雑誌. 28. 1-12 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amizuka,N., 他: "Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow." Microscopy Research and Technique. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 中村浩彰, 他: "骨シグナルと骨粗鬆症" 羊土社, 108 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小澤英浩: "最新骨粗鬆症" ライフサイエンス出版(印刷中),

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiraga,T.他: "Inhibitory cffects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor." Bone. 18・1. 1-8 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hara,F.他: "Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs." Bone. 18・1. 29-39 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Irie,K.他: "Immunohistochemical localization of parathyroid hormone/parathyroid hormone-related peptide receptor in rat tibiae." J.Bone Miner.Metab.14・1. 10-14 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakamura,H.他: "Ultrasturctural,enzyme,lectin and immunohistochemical studies of the erosion zone in rat tibiac." J.Bone Miner.Res.11・8. 1158-1164 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Amizuka,N.他: "Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal post-natal bone development : Analysis of mice heterozygous for PTHrP gene ablation." Dev.Biol.175. 166-176 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato,K.他: "17β-Estradiol increases calcium content in fetal parietal bones cultured in serum-free medium only at physiological concentrations." Bone. 19・3. 213-221 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中みか子、他: "卵巣摘出が成熟ラット下顎関節突起に及ぼす影響に関する軟X線写真画像解析" 日本補綴歯科学会雑誌. 40・4. 188-193 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nakamura,H.他: "Immunolocalization of CD44 and ERM family in osteoblasts and osteoclasts in mouse tibiae." J.Bone Miner.Res.11・11. 1715-1722 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Alpaslan,C.他: "Long-term cvaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system." British Journal of Oral and Maxillofacial Surgery. 34. 141-148 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kabasawa,M.他: "Effect of age on physiological and mechanically-stressed rat alveolar bone - a cytological and histochemical study-" Int.J.Adult Orthod.Orthognath.Surg.11・4. 313-327 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazama,J.J.他: "24R,25-dehydroxyvitamin D3 ameliorates the high-turnover bone diseases without suppressing parathyroid function in chronic renal failure in rats." Nephrology. 2. 361-366 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Amizuka,N.他: "Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide (PTHrP) gene deletion." Endocrinology. 137・11. 5055-5067 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Amizuka,N.他: "Cell-specific expression of the parathyroid hormone/(PTH)/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters." Endocrinology. 138・1. 469-481 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Amizuka,N.他: "Parathyroid hormone-related peptide (PTHRP) modulates normal post-natal bone development : Analysis of mice homozygous for PTHRP gene ablution." Dev.Biol. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiraga,T.他: "Effects of Bisphosphonate (Pamidronate) on Bone Resorption Resulting from Metastases of a Human squamous Cell Carcinoma.-Report of an Autopsy Case and Evaluation of Bone" J.Oral Maxillofac.Surg.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 小澤英浩: "かむこと,のむこと,食べること -咀嚼の科学-" 医歯薬出版株式会社, 270 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小澤英浩: "分子骨代謝学と骨粗鬆症" メディカルレビュー社, 405 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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