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EBV関連腫瘍の実態解明のための病理学的・分子病理学的研究

Research Project

Project/Area Number 08457061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

青笹 克之  大阪大学, 医学部, 教授 (30115985)

Co-Investigator(Kenkyū-buntansha) 菅野 祐幸  大阪大学, 医学部, 助手 (40252663)
大澤 政彦  大阪大学, 医学部, 講師 (80213685)
富田 裕彦  大阪大学, 医学部, 助手 (60263266)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsEBウイルス / 膿胸リンパ腫 / 鼻腔リンパ腫 / 慢性炎症 / リンパ腫 / 癌 / PCR / in situ ハイブリダイゼーション / 免疫組織化学 / HLA / サイトカイン
Research Abstract

1.慢性膿胸患者に発生する膿胸関連リンパ腫(PAL)はほぼ全例がEBV陽性であり、EBNA2を発現している。又、LMP-1発現細胞も少なからずみられる。このようなEVNA2、LMP-1発現PAL細胞が宿主のcytotoxic T細胞による免疫学的監視からのがれる機序として、腫瘍細胞によって分泌される免疫抑制性サイトカインIL-10が関与している可能性がある(Am J Pathol 1997)。又、PALには高率にp53遺伝子の変異が観察される(Cancer Res in press)。
2.進行性鼻壊疽の病態を示す鼻腔リンパ腫においてCD56陽性症例はEBVゲノム陽性であることを認めた。CD56はnatural killer細胞のマーカーと考えられていることから、NK細胞性鼻リンパ腫とEBV陽性との関連が示された。(Int J Cancer 1997)
3.胃癌におけるEBV陽性率を大阪と中国蘇州で検討したところ7-9%と同様であった。EBV認識に関係するといわれるHLA class IのうちA2の発現頻度について調べたところ、EBV陽性例と陰性例間で相違はなかった。(Int J Cancer 1997)
4.臓器移植患者に悪性腫瘍が多く発生するのは使用される免疫抑制剤の影響と考えられている。免疫抑制剤投与による免疫抑制状態下ではEBV潜伏感染細胞が排除されず、悪性腫瘍の発生に至る可能性が考えられる。本邦の腎移植患者1744例を調べたところ46例(2.6%)に悪性腫瘍の発生がみられた。EBVゲノムの検出されたのは悪性リンパ腫のみであった。(Int J Cancer 1997,J Cancer Res Clin Oncol 1997)

Report

(2 results)
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Kanno H, Aozasa K, et al.: "Induction of the immunosuppressive cytokine,interleukin-10,by Epstein-Barr virus expressing pyothorax-associated lymphoma : possible role in the development of overt lymphoma in immunosuppressive hosts." Am J Pathol. 150. 349-357 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita Y, Aozasa K, et al.: "Epstein-Barr virus in lymphoproliferative diseases in the sino-nasal region : close association with CD56 immunophenotype and polymorphic reticulosis morphology." Int J Cancer. 70. 9-13 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Qiu K, Aozasa K, et al.: "Epstein-Barr virus in gastric carcinoma in Suzuhou,China and Osaka,Japan : Association with clinicopathologic factors and HLA-subtype." Int J Cancer. 71. 155-158 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshida Y, Aozasa K, et al.: "Cancer risk after renal transplantation in Japan." Int J Cancer. 55. 27-32 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita Y, Aozasa K, et al: "Plasmacytoma of the gastrointestinal tract in Korea : higher incidence rate than in Japan and EBV-association." Oncology. 10. 933-938 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita Y, Aozasa K, et al: "Non-Hodgkin's lymphoma of the Waldeyer's ring as a manifestation of human T cell leukemia virus type-1-associated lymphoproliferative diseases in South West Japan." Mod Pathol. 123. 509-516 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshida Y, Aozasa K, et al: "Epstein-Barr virus in malignancies developing in renel transplants in Japan." J Cancer Res Clin Oncol. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hongyo T, Aozasa K, et al: "Nomura T.Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma(PAL)." Cancer Res. (in press). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanno H, Aozasa K, et al: "Appearance of different clones of Epstein-Barr Virus genome in recccurent tumor of pyothorax-associated lymphoma." Leukemia. (in revision). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 青笹克之: "新病理学入門" 南山堂, 308 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 青笹克之: "医学のあゆみ特集号「知っておきたい200ワード現代医学用語」" 医歯薬出版, 1 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita Y,Aozasa K,et al.: "Epstein-Barr virus in Hodgkin's disease in Japan." Cancer. 77. 186-192 (1966)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kanno H,Aozasa K,et al.: "Expression of Epstein-Barr virus latent infection genes and oncogenes in lymphoma cells lines derived from‐‐‐" Int J Cancer. 67. 86-94 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kanno H,Aozasa K,et al.: "Production of immunosuppressive cytokine,interleukin-10,by Epstein-Barr virus expressing pyothorax-associated lymphoma" Am J Pathol. 150. 349-357 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tomita Y,Aozasa K,et al.: "Epstein-Barr virus in Iymphoproliferative diseases in the sino-nasal region : Close association with CD 56 immunophenotype" Int J Cancer. 70. 9-13 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Qiu K,Aozasa K,et al.: "Epstein-Barr virus in gastric carcinoma in Suzhou,China and Osaka,Japan : Association with clinicopathologic factors" Int J Cancer. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Hoshida Y,Aozasa K,et: "Cancer risk after renal transplantation in Japan." Int J Cancer. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 青笹克之: "「病理学」青笹克之編著" 好生館, 123 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 青笹克之: "MALTリンパ腫 「知っておきたい200ワード」" 医歯薬出版 (印刷中),

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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