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Magnetometoric Evaluation of Cellular Toxicity of Semiconductor Material

Research Project

Project/Area Number 08457118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

AIWAZA Yoshiharu  Kitasato University School of Medicine, Department of Preventive Medicine and Public Health, Professor, 医学部, 教授 (10124926)

Co-Investigator(Kenkyū-buntansha) KARUBE Hitomi  Kitasato University School of Medicine, Assistant Professor, 医学部, 講師 (10161259)
KOTANI Makoto  Tokyo Denki University Faculty of Engineering, Professor, 工学部, 教授 (60057205)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1996: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsSemiconductor / Magnetometry / Microelectronics / Cellular toxicity / Gallium Arsenide / インジウムリン / インジウム砒素 / 石灰石 / インジウムヒ素
Research Abstract

Gallium arsenide(GaAs) has led to the development of electro-optical devices such as light emitting diodes and semiconductor lasers. Several reports point to pulmonary exposure to GaAs dust as a potential occupational health hazard.
A rapid decrease in the magnetic field after magnetization of the thorax of animals intratracheally instilled with magnetic particles has been noted and designated as "relaxation't. This phenomenon indicates a rapid decrease of remanent magnetic field following magnetization of the lungs due to random rotation of phagocytosed iron oxide particles in macrophages. Delayed relaxation and clearance of iron oxide have been observed in rabbits exposed to GaAs.
In this study, alveolar macrophages adhered to glass in the bottom of wells were exposed to iron oxide 60mug with or without GaAs 2Omug/ml in culture medium. Rapid relaxation was observed in the sample of GaAs free medium, whereas relaxation for the specimen with GaAs was delayed. GaAs impaired relaxation dose-dependently. Since addition of Ga_20_3 into the medium did not affect relaxation, arsenic is considered affecting relaxation. LDH release from cells also indicated toxic effect of GaAs on macrophages. Transmission electron microscopy revealed alterations of cell membrane, organelles in macrophages exposed to GaAs.
Other chemicals such as limestone, chrysotile fiber, titanium dioxide, silicon carbide were tested with the same methods and all substances except limestone showed appreciable in vitro delay of relaxation by this method.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report

Research Products

(24 results)

All Other

All Publications

  • [Publications] Sugiura, Y.: "Effect of limestone on the alveolar macrophages of hamsters." Advances in the Prevention of Occupational Respiratory Disease. 550-554 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mashimo, K.: "Effect of limestone on the lungs of rabbits." Advances in the Prevention of Occupational Respiratory Disease. 555-560 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okada, M.: "Magnetometric evaluation for the toxicity of titanium dioxide to alveolar macrophages." Advances in the Prevention of Occupational Respiratory Disease. 621-625 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karube, H.: "Magnetometric evaluation for the toxicity of silicon carbide whisker to alveolar macrophages in hamsters." Advances in the Prevention of Occupational Respiratory Disease. 626-630 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Keira, T.: "Magnetometric evaluation for the toxicity of crysotile fibers to alveolar macrophages." Advances in the Prevention of Occupational Respiratory Disease. 664-668 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karube, H.: "In vivo and in vitro magnetometric evaluation for toxicity of GaAs to alveolar macrophages" 25th International Congress on Occupational Health. 182 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiura, Y.: "Effect of limestone on the alveolar macrophages of hamsters." Advances in the Prevention of Occupational Respiratory Diseases. 550-554 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mashimo, K: "Effect of limestone on the lungs of rabbits." Advances in the Prevention of Occupational Respiratory Diseases. 555-560 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okada, M.: "Magnetometric evaluation for toxicity of titanium dioxide to alveolar macrophages." Advances in the Prevention of Occupational Respiratory Diseases. 621-625 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karube, H.: "Magnetometric evaluation for the toxicity of silicon carbide whisker to alveolar macrophages in hamsters." Advances in the Prevention of Occupational Respiratory Diseases. 626-630 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Keira, T.: "Magnetometric evaluation for the toxicity of chrysotile fibers to alveolar macrophages" Advances in the Prevention of Occupational Respiratory Diseases. 664-668 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Karube, H.: "In vivo and in vitro magnetometric evaluation for toxicity of GaAs to alveolar macrophages" 25th International Congress on Occupational Health. 182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiura,Y.: "Effect of limestone on the alveolar macrophages of hamsters." Advances in the Prevention of Occupational Respiratory Diseases. 550-554 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mashimo,K.: "Effect of limestone on the lungs of rabbits" Advances in the Prevention of Occupational Respiratory Diseases. 555-560 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Karube,H.: "In vivo and in vitro magnetometric evaluation for toxicity of GaAs to alveolar macrophages" 25th International Congrees on Occupational Health. 182 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aizawa,Y.: "In vivo and in vitro magnetometoric evaluation of GaAs toxicity to the lungs." Aspects on Environmental Toxicology. 21-25 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] Aizawa,Y.: "Effects of GaAs and Ga_2O_3 on magnetometric behavior of iron oxide particles in rabbit lungs" Appl.Organ.Chemistry.8(3). 207-213 (1994)

    • Related Report
      1998 Annual Research Report
  • [Publications] 相澤好治: "産業保健における磁界" 産業医学レビュー. 10(2). 83-97 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 苅部ひとみ: "細胞磁界測定" 臨床環境医学. 6(1). 31-33 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keira,T.: "Adverse effects of colophony" Ind Health. 35(1). 1-7 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kuwashima,A.: "National servey on occupational low back pain" Ind Health. 36. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 苅部ひとみ: "細胞磁界測定による、GaAs、InP及びInAsの細胞障害性について" 日本衛生学雑誌. 51・1. 203-203 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 相澤好治: "Magnetometric evaluation of cytotoxicity of macrophage:dissociation with LDH release" Book of abstracts. II. 327-327 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 苅部ひとみ: "「展望」:細胞磁界測定" 臨床環境医学.

    • Related Report
      1996 Annual Research Report

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Published: 1996-03-31   Modified: 2016-04-21  

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