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Induction of monocytic cell heterogeneity by two novel factors

Research Project

Project/Area Number 08457197
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNational Cancer of Neurology and Psychiatry (NCNP)

Principal Investigator

KAMO Isao  National Institute of Neuroscience, Department of Ultrastructural Research, Section Cheif, 神経研究所・微細構造研究部, 室長 (70108489)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Aiko  National Institute of Neuroscience, Department of Ultrastructural Research, Rese, 神経センター・神経研究所・微細構造研究部, 研究員 (70159010)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordsmacrophage / monocyte / biglycan / growth factor / M-CSF / GM-CSF / thymus / myoid cell / ミクロファージ
Research Abstract

The vertebrates contains skeletal muscle like cells, myoid cells, in the thymus. These cells appear preceding development of thymic lymphocytes and in particular in human they are postulated to be responsible for the pathogenesis of myasthenia gravis. We attempted to clone thymic myoid cells to investigate their possible physiological roles in thymic phsiology. We found that myoid cells produce two novel monocytic cell growth and differentiation factors, such as an 80kDa factor and a 100kDa factor. Genes for these two factors were cloned under the information deduced from amino acid sequences. We succeeded in producing biologically active recombinat 80 kDa and 100 kDa factors. The biologial activity of these two factors are different from GM-CSF,M-CSF and also different from each oather. Furthermore, these two factors were particularly found in the central region of the hyperplasia associated with myasthenia gravis, suggesting the importantce of these factors for induction and maintenace of the hyperplastic state. We are currently attempting to prepare the knockout mice for these two genes to establish their detailed functions in vivo and to produce reconbinant factors in large scale for clinical use.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] N.Iwakami, A.Kikuchi, T.Kunishita, I.Nonaka, I.Kamo: "Analysis of lymphoproliferative cytokines produced by thymic myoid cells" Immunology. 87. 108-112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Sakuragawa, I.Kamo, , et al: "Expression of markers of both neuronal and glial cells in human ammnitotic epithelial cells" Neuroscience Letter. 209. 2-12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Kamo, A.Kikuchi: "Moncytic linage cell growth and dfferntiaton factors produced by thymic oymid cells" European Journal of Heamatology. 57. 31-31 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi, I.Kamo: "Thymic myoid cells produce cytokines for lymphocytes and monocytic cells" Cancer Detection and Prevention. 20. 395-395 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi et al: "Haemopoietic biglycan produced by brain cells stimulates growth of microglian cells" Journal of Neuroimmunology. (in pres).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Tomoyasu it al.: "Identication of haemopoietic biglycan in hypeaplastic thymus asociated with myasthenia gravis" Journal of Neuroimmunology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi, H.Tomoyasu, I.Kamo: "J.Neuroimmunology(in Japanese)" The production of Haemopoietic Biglycan from Brain Cells, 58-59 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Iwakami, A.Kikuchi, T.Kunishita, H.Yamamoto, I.Nonaka, I,Kamo: "Analysis of lymphoproliferative cytokines produced by thymic myoid cells" Immunology. 87. 108-112 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Sakuragawa, I.Kamo: "Expression of markers for both neuronal and alial cells in human ammnitotic epithlial cells" Neurosci.Lett. 209. 2-12 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Kamo, A.Kikuchi: "Monocytic lineage cell growth and differentiation factors produced by thymic myoid cells" Eur, J.Haematl.57. 31-31 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi, I.Kamo: "Thymic myoid cells produce cytokines for lymphocytes and monocytic cells" Cancer Detect and Prevent. 20. 395-395 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi et al.: "Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells" J.Neuroimmunol. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Tomoyasu et al.: "Identification of haemopoietic biglycan in hyperplastic thymus associated with myasthenia gravis" J.Neuroimmunol. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Kikuchi, H.Tomoyasu, I.Kamo: "The production of Haemopoietic Biglycan from Brain Cells (in Japanese)" Neuroimmunology. 6. 58-59 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Iwakami,A.Kikuchi,T.Kunishita,I.Nonaka,I.Kamo: "Analysis of lymphoproliferative cytokines produced by thymic myoid cells" Immunology. 87. 108-112

    • Related Report
      1997 Annual Research Report
  • [Publications] N.Sakuragawa,I.Kamo,,et al: "Expression of markers for both neuronal and glial cells in human ammnitotic epithelial cells" Neuroscience Letter. 209. 2-12 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] I.Kamo,A.Kikuchi: "Monocytic lineage cell growth and differentiation factors produced by thymic myoid cells" European Journal of Heamatology. 57. 31-31 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Kikuchi,I.Kamo: "Thymic myoid cells produce cytokines for lymphocytes and monocytic cells" Cancer Detection and Prevention. 20. 395-395 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Kikuchi et al.: "Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells" Journal of Neuroimmunology. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Tomoyasu et al.: "Identification of haemopoietic biglycan in hyperplastic thmus asoclated with myasthenia gravis" Journal of Neuroimmunology. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Kikuchi,H.Tomoyasu,I.Kamo: "J.Neuroimmunology(in Japanese)" The production of Haemopoietic Biglycan from Brain Cells, 58-59 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] I.Kamo: "Expression of markers for both neuronal and glial cells in human ammniotic epithelial cells" Neuroscience Letters. 209. 9-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Kamo,A.Kikuchi: "Monocytic lineage cell growth and differentiation factors produced by thymic myoid cells" Eur.J.Haematology. 57(supl). 31-31 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Kikuchi,I.Kamo: "Thymic myoid cells produce multiple cytokines for lymphocytes and monocytic cells" Cancer Detection and Prevention. 20. 395-395 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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