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EXPERIMENTAL AND CLINICAL STUDY ON AN NOVEL STRATEGY AGAINST HEPATIC ARTERY THROMBOSIS AFTER LIVER TRANSPLANTATION

Research Project

Project/Area Number 08457297
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionSHINSHU UNIVERSITY,SCHOOL OF MEDICINE

Principal Investigator

HASHIKURA Yasuhiko  SHINSHU UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部附属病院, 講師 (10228398)

Co-Investigator(Kenkyū-buntansha) KAWASAKI Seiji  SHINSHU UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (80177667)
橋倉 泰彦  信州大学, 医学部附属病院, 講師 (10228398)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1996: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsLIVER TRANSPLANTATION / HEPATIC ARTERY THROMBOSIS / COAGULATION-FIBRINOLYTIC SYSTEM
Research Abstract

HEPATIC ARTERY THROMBOSIS AFTER ORTHOTOPIC LIVER TRANSPANTATION IS A SERIOUS COMPLICATION.WE HAVE DEVELOPED AN INTENSIVE ANTICOAGULANT THERAPY DURING AND AFTER LIVING-RELATED LIVER TRANSPLANTATION IN PEDIATRIC RECIPIENTS.EIGHTY-FOUR PATIENTS BETWEEN 5 MONTHS AND 60 YEARS OF AGE UNDER WENT LIVING-RELATED LIVER TRANSPLANTATION.THE MEAN DIAMETER OF THE ANASTOMOSED HEPATIC ARTERIES WAS 2.7 MM.THE ANTICOAGULANT THERAPY CONSISTED OF LOW MOLECULAR WEIGHT HEPARIN,ANTITHEROMBIN III CONCENTRATES,PROSTAGLANDIN E_1, FRESH FROZEN PLASMA AND A PROTEASE INHIBITOR.THE PROFILES OF THE COAGULATION AND FIBRINOLYTIC SYSTEMS WERE MONITORED BY MEASURING SEVERAL PARAMETERS,INCLUDING PLASMA LEVELS OF THROMBIN-ANTITHROMBIN III COMPLEX,ANTITHROMBIN III,PLASMIN-alpha 2 PLASMIN INHIBITOR COMPLEX,FIBRIN DEGRADATION PRODUCT D-DIMER,TISSUE TYPE-PLASMINOGEN ACTIVATOR AND PLASMINOGEN ACTIVATOR INHIBITOR-1. ACCELERATION OF THE COAGULATION SYSTEM AND DELAYED BECOVERY OF THE FIBRINOLYTIC SYSTEM WERE OBSERVED DURING THE EARLY POSTOPERATIVE DAYS.THE PLASMA LEVEL OF ANTITHROMBIN III ACTIVITY WAS MAINTAINED WITHIN THE NORMAL RANGE BY THE ADMINISTRATION OF ANTITHROMBIN III CONCENTRATES.NONE OF THE RECIPIENTS DEVELOPED HEPATIC ARTERY THROMBOSIS.WE BELIEVE THAT THE INTENSIVE ANTICOAGULATION THERAPY DEVELOPED IN THIS STUDY,THE MAIN CONCEPT OF WHICH ISTHE EARLY CORRECTION OF IMBALANCE BETWEEN THE COAGULANT AND ANTICOAGULANT SYSTEMS,COULD BECOME A MODEL FOR THE PREVENTION OF HEPATIC ARTERY THROMBOSIS IN PEDIA TRIC LIVER TRANSPLANTATION PATIENTS.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report

Research Products

(32 results)

All Other

All Publications

  • [Publications] Hashikura Y, et al: "Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation." Transplant Proc. 28. 1034-1035 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Donor selection for living-related liver transplantation" Transplant Proc. 29. 3410-3411 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Curent problems with liver transplantation for nepatic failure." Hepato-Gastroenterol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Urgent living-related liver transplantation using agraft with multiple intranepatic arterioportal" Transplantation. 64. 1076-1078 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Living related liver transplantation in adults" Ann Surgery. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Living related liver transplantation in children and adults." World J Surgery. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 橋倉 泰彦、他: "シクロスポリンの実際" 国際医学出版、東京, 5 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 橋倉 泰彦、他: "成人患者に対する生体部分肝移植、幕内雅敏監修" 中山書店、東京, (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S,Matsunami H,Terada M,Ikegami T,Nakazawa Y,Watanabe M,Chisuwa H,Kamijima T,Takagi S,Makuuchi M: "Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation." Transplant Proc. 28. 1034-1035 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ikegami T,Kawasaki S,Matsunami H,Hashikura Y,Nakazawa Y,Miyagawa S,Furuta S,Iwanaka T,Makuuchi M: "Should all hepatic arterial branches be reconstructed in living-related liver transplantation?" Surgery. 119. 431-436 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawasaki S,Hashikura Y,Matusnami H,Ikegami T,Nakazawa Y,Watanabe M,Iijima S,Makuuchi M: "Temporary shunt between right portal vein and vena cava in living related liver transplantation." J Am Coll Surg. 183. 74-76 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furuta S,Ikegami T,Nakazawa Y,Hashikura Y,Matsunami H,Kawasaki S,Makuuchi M: "Hpatic artery reconstruction in living donor liver transplantation from the microsurgeon Is point of view." Liver Transplantation and Surgery. 3. 388-393 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S,Miyagawa S,Terada M,Ikegami T,Nakazawa Y,Miwa S,Chisuwa H,Kubota T: "Donor selection for living-related liver transplantatin." Transplant Proc. 29. 3410-3411 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S,Miyagawa S,Terada M,Ikegami t, Nakazawa Y,Miwa S,Chisuwa H, Kubota T: "Impact of ABO compatibility and lymphocytotoxic crossmatch in living-related liver transplatation." Transplant Proc. 30. 127-128 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S,Miyagawa S,Terada M,Ikegami T,Nakazawa Y,Miwa S,Chisuwa H,Kubota T: "Living-related liver transplantation in children and adults." World J Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y,Kawasaki S,Miyagawa S,Terada M,Ikegami T,Nakazawa Y,Miwa S,Chiuwa H,Kubota T: "Current problems with liver transplantation for hepatic failure." Hepato-Gastroenterol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hashikura Y, et al: "Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation." Transplant Proc. 28. 1034-1035 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y, et al: "Donor selection for living-related liver transplantation" Transplant Proc. 29. 3410-3411 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y, et al: "Current problems with liver transplantation for hepatic failure." Hepato-Gastroenterol. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y, et al: "Urgent libving-related liver transprlntation using agraft with multiple intranepatic arterioportal" Transplantation. 64. 1076-1078 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y, et al: "Living related liver transplantation in adults" Ann Surgery. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y, et al: "Living related liver transplantation in children and adults." World J Surgery. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 橋倉泰彦、他: "シクロスポリンの実際" 国際医学出版、東京, 5 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 橋倉泰彦、他: "成人患者に対する生体部分肝移植.幕内雅敏監修" 中山書店、東京, (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura,Y.et al: "Immunosuppressant switching between cyclospovine and tacrolimus after liver transplantation" Transplantation Proceedings. 28・2. 1034-1035 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦.他: "肝移植術中術後の凝固線溶系の変動に関する研究" 外科. 58・2. 205-209 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦.他: "肝移植ドナーの術前後の栄養管理" JJPEN. 18・11. 833-836 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawasaki,S.et al: "Extended lateral segmentectorny using intraoperative ultrasound to obtain a partial graft" American Journal of Surgery. 171. 286-288 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawasaki,S.et al: "Temporary Shuat between right purtal veir and uera cava in living related liver transplantation" J.Am Coll Surg. 183. 74-76 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikegami T.et al: "Should all hepatic arterial branches be reconstructed in living-related liver transplantation?" Surgery. 119. 431-436 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦.他: "高木弘(編):シクロスポリンの実際「生体部分肝移植とシクロスポリン」" 国際医学出版, 19 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦.他: "丹羽寅文他(編):ベッドサイド消化器病学「肝区域切除術」" 南江堂, 5 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-03-31   Modified: 2016-04-21  

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