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Surgical Treatment of Arthythmia by Ablation of Selective Sinoatrial and Atrioventricular Parasympathetic Gangliias.

Research Project

Project/Area Number08457348
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

MISAKI Takuro  Toyama Med & Parm Univ, Dept of Surg, Professer, 医学部, 教授 (40092811)

Co-Investigator(Kenkyū-buntansha) KOTHO Keijyu  Toyama Med & Parm Univ, Dept of Surg, Research Head, 医学部, 助手 (80272904)
WATANABE Go  Toyama Med & Parm Univ, Dept of Surg, Assistant Professer, 医学部, 講師 (60242492)
Project Period (FY) 1996 – 1997
Project Status Completed(Fiscal Year 1997)
Budget Amount *help
¥6,900,000 (Direct Cost : ¥6,900,000)
Fiscal Year 1997 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 1996 : ¥6,000,000 (Direct Cost : ¥6,000,000)
Keywordsganglion / vagal syncope / selective stimulation / selective ablation / sinus bradycardia / atrio-ventricular block / thoracoscope / 胸腔鏡手術 / 上室性不整脈 / 選択的電気的刺激 / 迷走神経刺激装置 / 高解像度心表面マッピング電極
Research Abstract

1. We developed our original parasympathetic nerve stimulator and high resolusion epicardial mapping sheet electrode with 96 bipolar electrodes.
2. In animal study using dogs, parasympathetic intracardiac ganglia to the sinoatrial node was detected in the fat pad overlying the right pulmopnary vein at the junction of the right atrium. Vagally induced sinus bradicardia could not induced after radiofrequency ablation of this area. Parasympathetic ganglia to the atrio-ventricular node was detected in the fat pat of the junction of inferior vena cava and inferior left atrium. After ablation of this area, vagally induced atrio-ventricular could not induced. Light microscopic examination of ablated fat fad revealed the presence of the damaged ganglia cells.
3. In clinical case having aminiinvassive direct coronary bypass, stimulation of fad pad of right pulmonary vein using thoracoscopic approach was performed successfully to get sinus bradycardia.
This procedure made beating coronary bypass easy without extracorporial circulation.
Therefore surgical treatment of arrhythmia using thoracoscopic radiofrequency ablation is expected to be a new treatment for patients with vacal syncope.

Report

(3results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report

Research Products

(24results)

All Other

All Publications

  • [Publications] 山下 昭雄: "迷走神経性失神に対する外科治療の新しい試み" JPN Circ J. 60巻. 97- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Ohotake: "A new contact probe for intraoperative laser ablation." PACE. 19巻. 2060-5 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.Watanabe: "Bilateral minimally invasive direct coronary artery bypass grafting with the use of two arterial grafts." J Thorac Cardiovasc Surg. 113巻. 949- (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 上田 哲之: "迷走神経心臓枝刺激による心拍数制御の基礎的研究:MIDCABへの応用は可能か?" 日胸外会誌. 45巻. 1457- (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.Watanabe: "Bilateral minimally invasive direct coronary artery bypass(MIDCAB)using internal thoracic arteries." Ann Thoracic Surg. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.Watanabe: "Thoracoscopic radiofrequency ablation of the myocardium." PACE. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 三崎 拓郎: "WPW症候群:心肺蘇生例とその特徴" 医学書院(笠貫 宏), 166-70 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akio Yamashita et al.: "New surgical treatment for patients with vagal syncope." JPN Circulation J. 60. 97 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiroshi Ohotake et al.: "A new contact probe for intraoperative laser ablation." PACE. 19. 2060-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Go Watanabe et al.: "Bilateral minimally invasive direct coronary bypass grafting with the two arterial grafts." J Thoracic Cardio Vasc Surg. 113. 949 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Go Watanabe et al.: "Bilateral minimally invasive direct coronary bypass (MIDCAB) using internal thoracic arteries." Ann Thoracic Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] "Thoracoscopic radiofrequency ablation of myocardium." PACE. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山下昭雄: "心表面高周波アブレーションを用いた迷走神経心臓枝の選択的遮断に関する研究" 日胸外会誌. 45巻. 1372 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 上田哲之: "迷走神経心臓枝刺激による心拍数制御の基礎的研究:MIDCABへの応用は可能か?" 日胸外会誌. 45巻. 1457 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] G.Watanabe: "Bilateral minimally invasive direct coronary artery bypass grafting with the use of two arterial grafts." J Thorac Cardiovasc Surg. 113巻. 949 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] G.Watanabe: "Thoracoscopic chemical ablation of aconitine induced ventricular tachycardia in dogs." PACE. 20巻. 1578 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] G.Watanabe: "Bilateral minimally invasive direct coronary artery bypass(MIDCAB) using internal thoracic arteries." Ann Thoracic Surg. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] G.Watanabe: "Thoracoscopic radiofrequency ablation of the myocardium." PACE. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 三崎拓郎: "WPW症候群:心肺蘇生例とその特徴" 医学書院(笠貫 宏編), 166-70 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 上田哲之: "臨床例における心表面単相電位測定の意義" 心臓ペーシング. 12. 202- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 上田哲之: "迷走神経洞結節枝刺激が心拍変動に与える影響" 心電図. 16. 492- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山下昭雄: "心房性不整脈に対する胸腔鏡下手術の実験的検討" 心臓ペーシング. 12. 217- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 上田哲之: "迷走神経心臓枝刺激が心臓最早期興奮部位に与える影響" JPN Circ J. 60. 235- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山下昭雄: "迷走神経性失神に対する外科治療の新しい試み" JPN Circ J. 60. 97- (1996)

    • Related Report
      1996 Annual Research Report

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Published : 1996-04-01   Modified : 2016-04-21  

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