| Project/Area Number |
08457352
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Second department of surgery, faculty of medicine, University of the Ryukyus. |
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Principal Investigator |
KOJA Kageharu University of the Ryukyus, faculty of medicine professor, 医学部, 教授 (10101479)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Makie University of the Ryukyus, faculty of medicine Assistant professor, 医学部, 助教授 (80040187)
MIYAGI Kazufumi University of the Ryukyus, faculty of medicine, 医学部・附属病院, 助手 (00229808)
KUDAKA Manabu University of the Ryukyus, faculty of medicine, 医学部, 助手 (30295315)
KUNIYOSHI Yukio University of the Ryukyus, faculty of medicine Associate professor, 医学部・附属病院, 講師 (50153317)
赤崎 満 琉球大学, 医学部, 助手 (00192881)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | selective perfusin / thoracoabdominal aneurysm / ATP / renal ischemia / inorganic phosphorus / actic acid / viability |
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| Research Abstract |
Object : Selective perfusion (SP) of the visceral arteries is a useful adjunctive method for the prevention of organic ischemia during thoracoabdominal aneurysm surgery. However, the appropriate perfusion flow rate is unclear. The present study attempts to characterize the changes seen in the kidney associated with various perfusion flow rates. Method : 28 dogs underwent laparotomy and both kidneys were exposed. A cannula delivering perfusate was introduced in to the left renal artery. The kidney was perfused selectively with normothermic blood for 2 hrs and then returned to normal circulation for 2 hrs. The contralateral kidney served as a control. ATP,inorganic phosphorus (IP) and lactic acid (LA) of the renal cortex were measured. The perfused kidneys were classified into the following 4 groups according to perfusion flow rate.
Group 1 (G1) : perfusion flow 10% of native renal blood flow. Group 2 (G2) : 25%. Group 3 (G3) : 50%. Group 4 (G4) : 100%. Results : There was a significant difference in ATP content between G1, G2 and the control group after 2 hrs SP.However, the ATP content was restored in G2 after 2hrs reperfusion. No significant difference was observed in G3 and G4. The level of IP and LA increased significantly in G1 after SP and then decreased after reperfusion. Morphological change was slight in G2, and more pronounced in G1 and G4. During SP,mean renal artery pressure exceed 200 mmHg in G4. Conclusion : The renal function was maintained to almost normal in G3, whereas reversable improvement of renal function was seen in G2.
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