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Trial manufacture of the automatic and remote-controlled apparatus for the mass production of ^<195>mpt radiolabeled compounds

Research Project

Project/Area Number 08559011
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 広領域
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

AKABOSHI Mitsuhiko  Research Reactor lnstitute Kyoto University, Professer, 原子炉実験所, 教授 (00027418)

Co-Investigator(Kenkyū-buntansha) TAKADA Jitsuya  Kyoto University, Research Fellow, 原子炉実験所, 助手 (10115868)
KINASHI Yuko  Kyoto University, Research Fellow, 原子炉実験所, 助手 (80252534)
MASUNAGA Shinichiro  Kyoto University, Associate Professor, 原子炉実験所, 助教授 (80238914)
ONO Koji  Kyoto University, professor, 原子炉実験所, 教授 (90122407)
KAWAI Kenichi  Kyoto University, Resserch Fellow, 原子炉実験所, 助手 (30110761)
田野 恵三  京都大学, 原子炉実験所, 助教授 (00183468)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥12,700,000 (Direct Cost: ¥12,700,000)
Keywords^<195>mPt / ^<195>mPt-CDDP / Mass Production / HPLC / rare earth element / ^<195M>Pt / シスプラチン / カルボプラチン / PWA-2114R / 254-S
Research Abstract

We have synthesized various ^<195>mPt radiolabeled compounds and successfully applied these compounds to the fundamental studies in the biomedical field. As the specific activity of the ^<195>mPt is high enough (12 MBq/mg-Pt) to be applied in these studies as the tracer and the half-life of ^<195>mPt is too short (4.02d) to be commercially available, there have been a great need of the application from the scientists of both the domestic and foreign countries.
The present application was made to construct the automatic and remote-controlled apparatus for the mass-production of ^<195>mPt-radiolabeled compounds. The apparatus mainly consist of the two parts, the automatic synthesis device and the automatic separation-purification device (HPLC). By this application, we could purchase the later part, while another application proposed afterward made us possible to get the former part. The apparatus is now fully warking to synthesize radiolabeled Pt-as well as various rare earth element-compounds.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] M.Akaboshi: "Relationship between cell-killing effeciency and number of platinum atoms binding to DNA,RNA and protein molecule in HeLa cells" Jpn.J.Cancer Res.87. 178-183 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Ono: "Radio biological evidence suggesting heterogeneous microdistbution of boron compounds in tumors : It relation to quiescent cell" Int.J.Radiat.Oncol.Biol.Phys. 34. 1081-1086 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Cell-killing effiency and number of plantinum atoms binding to DNA,RNA and protein moleculeo of HeLa cells treated with tran-DDP" Jpn.J.Cancer Res.88. 506-511 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "The relationship between cellkilling effect and number of lamtionide atoms bound to DNA,RNA moleculeo in caltered HeLa cell treated^<aiR> REE" J.Radioanal.Nucl.Chem.217. 179-183 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Kinashi: "Mutagenic effects at HPRT locus induced in Chinese hamster ovary cells by thermal meutrons with or without boron compound" Mutation Res.377. 211-215 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Masunaga: "Alleration in the hypoxic fraction quiescent cell populations by hyperthermia at mild temperatures" Int.J.Hyperthermia. 13. 401-411 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Relationship between Cell-kelling efficiency and number of Platinum atoms binding to DNA,RNA and protein molecules in HeLa Cells." Jpn.J.Cancer Res. 87. 178-183 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Ono: "Radiobiolugical evidence Suggesting heteogeneous microdistribution of boron compounds in tumors : HS relation to quiescent cills." Int.J.Radiat.Oncol.Biol.Phys.34. 1081-1086 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Cell killing efficiency and number of Platinun atoms binding to DNA,RNA and protein molecules of HeLa cells treated with Combirlctivos 6 trans-diaminedichloro Platinum (II) and hyperthermia" Jpn.J.Cancer Res.88. 506-511 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akahoshi: "The relationship between cell-killing effect and number of lanthanide atoms bound to DNA,RNA and protein molecules in Culfurez HeLa cells treated with rave earth elements" J.Radioanal.Nucl.Chem. 217. 179-183 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Kinashi: "Mutagenic effects at HPRT locus induced in Chinese hamster ovary cells by thermal neutrons with or without boron compound" Mutation Res. 377. 211-215 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Masunaga: "Alteration in the byposic fraction of quiescent cell populations by hyper thermla" Int.J.Hyperthermia. 13. 401-411 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Relationship between cell-killing efficiency and number of platinum atoms binding to DNA,RNA and protein malecule in HeLa cell" Jpn.J.Cancer Res.87. 178-183 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Ono: "Radio biological evidence suggesting heterogeneous microdia of boron compounds in tumors : it relation to quiescent cell" Int.J.Radiat.Oncol,Biol.Phys.34. 1081-1086 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "Cell-killing efficiency and number of platinum atoms binding to DNA,RNA and protein molecules of Hela cells treated with tren DDP" JPn.J.Cancer Res.88. 506-511 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "The relationship between cell-killing effect and number of lanthari atomy bound to DNA , RNA molecules O in cultured Hela cell teated Ree" J.Radioanal.Nucl.Chem.217. 179-183 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Kinashi: "Mutagenic effects at HPRT locus induced in chinese hamster ovu cells by thermal nutrons with or with out boron compound" Mutation Res.377. 211-215 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Masunaga: "Alteration in the hypopic fiaction of quiescent cell populations by byperthermia at mild temperatures" Int.J.Hyperthermia. 13. 401-411 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi,K.Kawai et al: "Cell-billing efficiency and anmbea of Platinum atoms binding to DNA,RNA and Protein molecule of Hela cells treated with combinations of TDDP and hypeerthermia" Jpn.J.Cancer Res. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi,et al: "The relationship between cell killing effect and number of lanthanide atoms bound to DNA molecules in Hela cells treated with rare earth elements" J.Radioanal.Nucl.Chem. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi,K.Kawai: "Relation ship between cell-killing efficinay and number of Platinum atoms binding to DNA,RNA and Protein moleailes in Hela Cells treated with cis-diamine(glycolate)Pt" Jpn.J.Cancer Res. 87-2. 178-183 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi,K.Kawai: "Effet of hyperthermie on the number of Platinum atoms binding to DNA of HeLa cells treted with Platinum 195m radiolabeled 4,5-diaminedichloropaltinum(II)." Int.J.Radiat.Biol.66. 215-220 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Masunaga,K.Ono et al: "An attempt at enhance chemisensitiuity of quiescent cell populations in solid tumors by combined treatment with nivtinamid and carbogen." J.Cancer Res.Clin.Oncol. 122. 533-540 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Ono,S.Masanaga et al: "Radiobiological evidence suggesting heterogeneous microdistubution of born compound in tumors." Omt.J.Radiat.Oncol Biol.Phy. 34. 1081-1086 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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