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Physioengineering approach to the autonomic nervous control of the heart rate fluctuations in developing embryos.

Research Project

Project/Area Number 08650471
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 計測・制御工学
Research InstitutionMuroran Institute of Tehnology

Principal Investigator

TAZAWA Hiroshi  Muroran Institute of Technology, Department of Electrical and Electronic Engineering, Professor, 工学部, 教授 (40002109)

Co-Investigator(Kenkyū-buntansha) PEARSON James T.  Muroran Institute of Technology, Department of Electrical and Electronic Enginee, 工学部, 助手 (30261390)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsAutonomic nervous control / Autonomic drugs / Arterial blood pressure / Embryonic heart rate / Heart rate fluctuations / Pipping / Allometry / Embryonic respiratory movements / 尿膜動脈圧 / 心拍数無侵態計測 / 鳥類卵 / 鳥類胚 / 心拍数無侵熱計測 / 心拍数成長パターン / 心拍数アロメトリー特性 / 心拍数変動性と不規則性 / 低酸素及び高酸素濃度環境
Research Abstract

1.Daily changes (developmental patterns) of embryonic heart rate (HR) of the king quail (mean egg mass=about 6g) were determined during the whole incubation period. Allometric equation of HR in 9 species of the precocial birds including the king quail and ostrich was redulted in HR=440・M^<-0.128> (M=egg mass in g).
2.Developmental patterns of embryonic HR in chickens were determined by impedancecardiogrpahy during the first half of incubation without impeding gas exchange through the eggshell. Additionally, the responses of embryonic HR to 10% O_2 and 100% O_2 exposoures were investigated.
3.Embryonic HR of chickens was measured continously by acoustocardiography throughout the last half of incubation. In addition to the HR irregularities which began to appear on days 14-16, the HR variability (cyclic oscillation) with period of 0.5-1 hour was found to appear on these days and the magnitude of the oscillation became augmented with embryonic development.
4.It was found that appearance and time course of respiratory movements due to lung ventilation of embryos prior to and during internal pipping could be recorded by acoustocardiography. This is the new finding which may contribute to an investigation of ontogenic mechanism of pulmonary gas exchange in avian embryos.
5.Using the electrocardiography, we could record the HR fluctuations of chick embryos during internal and external pipping period. It was found that the HR variability and irregularities and their time course were particularly unique in external pipping embryos.
6.Autonomic nervous controls of the HR fluctuations during the prenatal development of chick embyos were investigated by dosing intravenously the various autonomic drugs. It was found that the transient deceleration of HR was produced by parasympathetic nervous functions. But, the relation between sympathetic nervous functions and various patterns of HR accleration was not clear and need further investigation.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Akiyama, R.: "Noninvasive determination of instantaneous heart rate in developing avian embryos bymeans acoustocardiogram." Medical & Biological Engineering & Computing.35. 323-327 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ono, H.: "Ballistocardiogram of avian eggs determined by an electromagnetic induction coil." Medical & Biological Engineering & Computing.35. 431-435 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Pearson, J.T.: "Development of heart rate in precocialking quail,Coturnix chinensis." Journal of Experimental Biology.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Heart rate in developing ostrich embryos." British Poultry Science.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Effect of incubator humidity on embryonic heart rate in the ostrich." J.of World Poultry Association. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Avian cardiovascular development. In:Development of Cardiovascular Systems." Cambridge University Press., 360 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Incubation physiology. In:Avian Physiology" Academic Press.(in press), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akiyama, R.: "Noninvasive determination of instantaneous heart rate in developing avian embryos by means of acoustocardiography" Med.& Biol.Eng.& Comput.vol.35. 323-327 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ono, H.: "Ballistocardiogram of avian eggs determined by an electromagnetic induction coil.Med.& Biol.Eng.& Comput." vol.35. 431-435 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Pearson, J.T.: "Development of heart rate in precocial king quail, Coturnix chinensis." J.Exp.Biol.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Heart rate in developing ostrich embryos." Br., Poult.Sci.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Effect of incubator humidity on embryonic heart rate in the ostrich." J.of World Poultry Association. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: "Effect of incubator humidity on embryonic heart rate in the ostrich." J.of World Poultry Association. (in press). (1998)Tazawa, H.:

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Cambridge University Press.: Development of Cardiovascular Development(Avian cardiovascular development). 360 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa, H.: Avian Physiolsogy (Incubation physiology). Academic Press, (in press.), (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tazawa,H.: "Avian cardiovascular development." In:Development of Cardiovascular Systems,Cambridge University Press.193-210 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akiyama,R.: "Noninvasive determination of instantaneous heart rate in developing avian embryos by means of acoustocardiogram" Medical & Biological Engineering & Computing. 35. 323-327 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ono,H.: "Ballistocardiogram of avian eggs determined by an electromagnetic induction coil." Medical & Biological Engineering & Computing. 35. 431-435 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tazawa,H.: "Incubation physiology." In:Avian Physiology. Academic Press.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Pearson,J.T.: "Development of heart rate in the precocial king quail, Coturnix chinensis." Journal of Experimental Biology.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tazawa,H.: "Effect of incubator humidity on embryonic heart rate in the ostrich." J.of World Poultry Association.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ono,H.: "Ballistocardiogram of avian eggs determined by an electromagnetic induction coil." Medical & Biological Engineering & Computing. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akiyama,R.: "Noninvasive determination of instantaneous heart rate by means of acoustocardiogram in developing avian embryos." Medical & Biological Engineering & Computing. (in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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