|Budget Amount *help
¥2,200,000 (Direct Cost : ¥2,200,000)
Fiscal Year 1997 : ¥1,100,000 (Direct Cost : ¥1,100,000)
Fiscal Year 1996 : ¥1,100,000 (Direct Cost : ¥1,100,000)
Background : How Helicobacter pylori infection affects gastric acid secretion is still unclear.
Methods : Gastric juice pH and a mmonia concentrationing astric juice, serum gastrin level, and grade of gastritis according to the Sydney System were determined for patients with gastric ulcer (GU) and duodenal ulcer (DU) before and a ftertreatment with lansoprazole and a moxicillin, and results were compared with H.pylori-negative controls.
Results : Scores for H.pylori-density, atrophy, metaplasia, and activity of gastritis in the corpus were higher in patients with GU,especially proximally those with located GU,than in those with DU.Gastric juice pH was significantly higher in GU patients than in DU patients and controls. After eradication of H.pylori, gastric juice pH and serum gastrin levels in both GU and DU patients were significantly decreased to control levels. In patients without eradication of H.pylori, no significant changes in those parameters were observed.
Conclusions : These findings suggest that H.pylori infection and gastritis in the corpus suppress acid secretion and increase gastric juice pH,resulting in hypergastrinemia, and that eradiction of H.pylori normalizes acid secretion and serum gastrin levels.