Water barrier function and lipid metabolism in epidermis
Project/Area Number |
08670953
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Niigata University |
Principal Investigator |
YAMAMOTO Ayako Niigata Univ.School of med., Dept.of Dermatology, Associate Prorssor, 医学部, 助教授 (00200783)
|
Project Period (FY) |
1996 – 1997
|
Project Status |
Completed (Fiscal Year 1997)
|
Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
Keywords | Cutaneous fatty acid-binding protein / Lipid metabolism / water barrier function / Psoriasis / 水分バリアー機能 / 脂質代謝 / 表皮脂質 |
Research Abstract |
Cutaneous fatty acid-binding protein (C-FABP) has been newly discovered from rat skin. The immunohistochemical study revealed that G-FABP is strongly expressed in rat epidermis.Recently, a highly homologous protein to rat C-FABP was found in psoriatic epidermis, which is termed psoriasis-associated fatty acid-binding protein (PA-FABP). In the present study, we investigated the expression of PA-FABP in normal and pathological human skin using immunohistochemical techniques. In normal skin, PA-FABP was expressed in basal and prickle cell layrs, and more strongly in the granular cell layr. The expression pattern of PA-FABP was similar to that of C-FABP on rat skin. In psoriatic skin, PA-FABP was expressed in suprabasal layrs and more strongly in more differentiated keratinocytes. In squamous cell carcinoma, PA-FABP showed very strong expression in squamous nests. Thses results indicate that PA-FABP is a human homologue of C-FABP.Moreover, it is suggested that C-FABP has important roles in the transport and metabolism of fatty acids in epidermis and that altered lipid metabolism may affect the proliferation and/or differentiation of keratinocytes.
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Report
(3 results)
Research Products
(21 results)