| Project/Area Number |
08671055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The Jikei University School of Medicine |
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Principal Investigator |
SHIGEMATSU Takashi (1997-1998) The Jikei University School of Medicine Medical, Assistant Professor, 医学部, 講師 (30187348)
川上 憲司 (1996) 東京慈恵会医科大学, 医学部・放射線医学講座, 教授 (10056814)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Yutaka The Jikei University School of Medicine Medical, Assistant Professor, 医学部, 講師 (30166376)
SEKIGUCHI Chiharu The Jikei University School of Medicine Medical, Professor, 医学部, 教授
重松 隆 東京慈恵会医科大学, 医学部・内科学講座第2, 講師 (30187348)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Micro fravity / Bone Mineral Density / DEXA / Calcium / Space flight / 微少重力 / 骨塩 / 宇宙飛行士 / 脂肪量 / 除脂肪量 / 丘中La値 / 男性宇宙飛行士 / 骨塩量変化 / 荷重骨 / 微少重力環境 |
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| Research Abstract |
The micro-gravity environment in outer space markedly effects bone, muscle and calcium metabolism. It has been reported that osteoporosis was occurred in relative short term space flight.
This mechanism of the bone mineral loss in the micro-gravity condition was not investigated in the detail in Japan because of little experience of astronauts in the microgravity environment. We evaluated the changes in the bone mineral density and calcium metabolism in the Japanese astronauts before and after four times of space-flight. Bone mineral density (BMD) was measured with dual energy X-ray absorptiometory(DXA)and UBD (ultrasound bone densitometory). The bone mineral density were measured whole body, lumbar spines, femur, and calcaneus. The measurements were scheduled on L-60(60days before the launch of the space flight), L-30 and R-3 (3days after return of the space flight), R-1O, R-30, R-60, R-120. Blood and urine sample were taken and collected by NASA.The items measured in the samples were electrolyted(sodium, potassium calcium etc.)
The results of changes in BMD were drifted because there were only four subjects with different age and flight durations. The tendency of decreased BMD in the weight-bearing bones lumbar spine and calcaneus was observed. The loss of calcium in urine increased in space flight. The kidneys were influenced by the loss of calcium in urine. It is expected that our results could support the next space flight and future space voyages.
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