| Project/Area Number |
08671343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
TAZAWA Kenji TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,PROFESSER, 医学部, 教授 (80018887)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Masatoshi TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,ASSISTANT, 医学部, 教務職員 (30143861)
HONDA Takashi TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,VICE PRESIDENT, 副学長 (40019914)
TAKEMORI Shigeru TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,LECTURER, 附属病院, 講師 (30227061)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Apple pectin / Dietary fiber / Hepatic metastasis / free radical / Carcinogeneses / pectin / Cancer prevention / アップル、ペクチン |
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| Research Abstract |
Highly reactive oxygen-derived free radicals may play a role in carcinogenesis and hepatic metastasis. Free radical scavenging activity of apple pectin (Oligosaccharides and Oligogalacturonic acids) and components of Oligosaccharides used for the attenuation of colon carcinogenesis and hepatic metastasis, were investigated in vivo and in vitro. The used exprimental system was a radical scavenging action against superoxide anion radical and hydroxyl radical by the electron spin resonance technique. Oligosaccharides of apple pectin showed radical scavenging activity in a concentration-dependent manner in vitro, while on the han there are not significant in vivo. Components of Oligogalacturonic acids showed radical scabenging activity only in lowest molecular weight. The results indicate that the components of apple pection treated for prevention of carcinogenesis and metastasis were good radical scabenger that could possibly prevent the immune suppression of hepato-portal system.
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