Project/Area Number |
08671777
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | KAWASAKI MEDICAL SCHOOL |
Principal Investigator |
TORIUMI Takashi Kawasaki Medical School.Medicine, Instructor, 医学部, 講師 (40242424)
|
Co-Investigator(Kenkyū-buntansha) |
YOKOTA Kimio Kawasaki Medical School.Medicine, Assistant Proffessor, 医学部, 助教授 (30210610)
SARI Atsuo Kawasaki Medical School.Medicine, Professor, 医学部, 教授 (80035203)
|
Project Period (FY) |
1996 – 1997
|
Project Status |
Completed (Fiscal Year 1997)
|
Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
Keywords | Dlaphragmatic blood flow / Sepsis / Mechanical ventilation / ARDS / Multiple organ failure |
Research Abstract |
This study was designed to examine the effects of low dose endotoxin (2 mug/kg) on respiratory muscle blood flow in spontaneously breathing dogs. Blood flow to diaphragm, other respiratory muscles, kidney, and alimentary canal was measured by colored microsphere tracing technique. The work of breathing was calculated from esophageal pressure-tidal volume curve by using pulmonary monitor CP-100 (ATOM Co.). Two hours after endotoxin administration, cardiac output and blood pressure amounted to 54% and 56% of the control value, respectively. And even if cardiac output did decrement, the blood flow to diaphragm and other respiratory muscles increased in approximately 3 times. The renal blood flow and the alimentary canal blood flow did decrement in approximately 60%. The work of breathing increased by 48% of control value. These data suggested that when bacterial infection has occurred, the blood flow to the kidney and alimentary canal was become low perfusion state relatively because of increment of the blood distribution to the respiratory muscles from early stage thought clinical manifestation was slightly changes. If low perfusion state lasts, organ incompetence such as kidney, alimentary canal happens, and suggests potency developing in multiple organ failure. We conclude that blood flow distribution between the respiratory muscles and other major organs was affected by endotoxin administration. We will examine what kind of artificial ventilation is appropriate and what kind of drug therapy is more effective in future.
|