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Studies of Floral Antitumor Medicines in Yunnan Province

Research Project

Project/Area Number 09042010
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research Field 応用薬理学・医療系薬学
Research InstitutionTeikyo University

Principal Investigator

NISHIMURA Toshio  School of Science and Engineering Teikyo University, professor, 理工学部, 教授 (10013327)

Co-Investigator(Kenkyū-buntansha) 姚 新生  瀋陽薬科大学, 教授
SAKUDA Shohei  Department of Applied Biological Chemistry, The University of Tokyo, associate professor, 大学院農学生命科学研究科, 助教授 (80192087)
TSURUO Takashi  Institute of Molecular and Cellular Biosciences, The University Tokyo, professor, 分子細胞生物学研究所, 教授 (00012667)
崔 承彬  北京生物医薬研究所, 教授
しょう 剛  瀋陽薬科大学, 教授
YAO Xin-sheng  Department of Phytochemistry Shenyang Pharmaceutical University, professor
CUI Cheng-bin  Beijing Institute of Biomedicinal Research, professor
SHAO Gang  Department of Phytochemistry Shenyang Pharmaceutical University, professor
劭 剛  瀋陽薬科大学, 教授
Project Period (FY) 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1997: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsAntitumor activity / cytotoxity / Yunnan Provience / BRM activity / Antioxidative activity / Benibana / Kamebakurin / ferulic acid / 雲南植物圏
Research Abstract

Studies of Floral Antitumor Medicines in Yunnan Province.
1) On the basis of 1997 project on the studies of floral antitumor medicines in Yunnan province, 116 herbal plant samples were collected from the province area of Yunnan and Sichuan. The aqueous and alcoholic extracts were tested inhibitory activity against mouse leukemia P388/ADM and human leilira K562/ADM cells, together with BRM and antioxidative activities. As a results, 15 kinds of the plant extracts showed strong biological activity.
Isolation of these active principles are under progress.
2) Extracts of Terminalia Chebula Retaz showed a marked antitumor activity in vitro against mouse leukemia P388/ADM. The active principles were isolated in pure form which were identified as arjunglucoside I and arjungenein. Extract of Plectranthus excisus Mexim showed a strong antitumor activity against P388/ADM cells in vitro. The active principle was isolated in pure form which was identified as kamebakaurin.
3) Water extracts of Carthmus tinctorius showed antitumor activity against transplantable mouse breast cancer FM3A. Two active compounds were isolated in pure form by alcohol precipitation and gel filtration methods which were characterized as the polysaccharides and the name SF1 and SF2 were given. The compounds were not inhibited the growth of cultured FM3A cells in vitro. from the result, the antitumor activity of these compounds may be due to activation of host mediated mechanisms. The mechanisms of action are now under study.
4) Extract of Casealpinia sappan L showed antioxidative activity in TBA method used the rabbit erythrocyte membrane ghost. The active principle was isolated in pure form which was identified as ferulalic acid.

Report

(2 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] T. Nishimura. et al.: "Isolation and structure elucidation of the biologically active components of Terminalia chebula Retzius (Combretaceae)"KIMIKA. 12. 1-10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Nishimura. et al.: "Immunosuppressive effects of gallic acid and Chebulagic acid an CTL-mediated cytotoxicity"Biol. Pharm. Bull.. 20. 1017-1019 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Tsuruo. et al.: "Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from western diamondback rattlesnake venom"J. Biol. Chem.. 272. 9539-9542 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Tsuruo. et al.: "Action cleavage by CPP-32/apopain during the development of apoptosis"Oncopgene. 14. 9539-9542 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S. Sakuda. et al.: "Stereospecific reduction of virginiamycin M1 as the virginiamycin resistance pathway in Streptomyces virginiae"Antimicrobiol Agents and Chemotheraphy. 40. 595-601 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C-B. Cui. et al.: "Screening of cell cycle inhibitor from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210"Bioorg. Med. Chem.. 5. 193-203 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Nishimura et al.: "Isolation and structure elucidation of the biologically active components of Terminalia chebula Retzius (Combretaceae)"KIMIKA. 12. 1-10 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Nishimura et al.: "Immunosuppressive effects of gallic acid and Chebulagic acid an CTL-mediated cytotoxicity"Biol. Pharm. Bull. 20. 1017-1019 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Tsuruo et al.: "Apoxin l, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from western diamondback rattlesnake venom"J. Biol. Chem. 272. 9539-9542 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T. Tsuruo et al.: "Action cleavage by CPP-32/apopain during the development of apoptosis"Oncopgene. 14. 1007-1012 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S. Sakida et al.: "Stereospecific reduction of virginiamycin M1 as the virginiamycin resistence pathway in Streptomyces virginiae"Antimicrobiol Agents and Chemotheraphy. 40. 595-601 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C B. Cui. et al.: "Screening of cell cycle inhibitor from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsft210"Bioorg. Med. Chem.. 5. 193-203 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Nishimura.et al.: "Isolation and structure elucidation of the biologically active components of Terminalia chebula Retzius(Combretaceae)." KIMIKA. 12. 1-10 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Nishimura.et al.: "Immunosuppressive effects of gallic acid and Chebulagic acid an CTL-mediated cytotoxicity." Bio1.Pharm.Bull.20. 1017-1019 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Tsuruo.et al.: "Apoxin I,a nobel apoptosis-inducing factor with L-amino acid oxidase activity purfied from western diamondback rattlesnake venom." J.Biol.Chem.272. 9539-9542 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Tsuruo.et al.: "Action cleavage by CPP-32/apopain during the development of apoptosis." Oncopgene. 14. 9539-9542 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Sakuda.et al.: "Stereospecific reduction of virginiamycin M1 as the virginiamycin resistance pathway in Streptomyces virginiae." Antimicrobiol Agents and Chemotheraphy. 40. 595-601 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] X.S.Yao.et al.: "Furostanol glycosids from bullbs of Allium Chinese." Phytochemistry. 41. 283- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] C-B.Cui.et al.: "Novel mammalian cell cycle inhibitors,tryprostatins A,B and other diketopiperazines produced by Aspergillus fumigatus. I Taxonomy,fermentation, isolation an biological properties." J,Antibiot.49. 527-533 (1996)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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