Grant-in-Aid for Scientific Research (A)
|Allocation Type||Single-year Grants|
|Research Institution||HOKKAIDO UNIVERSITY|
TAKAHASHI Kyoko(1998-1999) School of Medicine, Hokkaido Univ., Inst., 医学部, 助手 (50292008)
斎藤 和雄(1997-1998) 北大, 医学部, 教授 (80000917)
HOSOKAWA Toshiyuki Center for Res. And Develop. In Higher Edu., Hokkaido Univ., Asso. Pro., 高等教育機能開発総合センター, 助教授 (00157025)
SAITO Takeshi School of Medicine, Hokkaido Univ., Asso. Prof., 医学部, 助教授 (40153811)
SAITO Kazuo Hokkaldo Univ., Professor Emeritus, 名誉教授 (80000917)
SHIDO Koichi School of Medicine, Hokkaido Univ., Inst., 医学部, 助手 (20206098)
KURASAKI Masaaki Grad. School of Env. Earth Sci., Hokkaido Univ., Inst., 大学院・地球環境科学研究科, 助手 (80161727)
高橋 恭子 北海道大学, 医学部, 助手 (50292008)
|Project Period (FY)
1997 – 1999
Completed(Fiscal Year 1999)
|Budget Amount *help
¥30,200,000 (Direct Cost : ¥30,200,000)
Fiscal Year 1999 : ¥5,200,000 (Direct Cost : ¥5,200,000)
Fiscal Year 1998 : ¥8,000,000 (Direct Cost : ¥8,000,000)
Fiscal Year 1997 : ¥17,000,000 (Direct Cost : ¥17,000,000)
|Keywords||stress / immune function / Anaerobic Threshold / VDT work / combined effects / zinc / White Blood Cells / Diabetes Mellitus / カテコールアミン / 老化ストレス / 糖尿病 / Tリンパ球 / ストレス中枢 / リンパ球サブセット|
In the present study, we intended to evaluate the mechanism of stress reaction in the central nervous system and effects of stress on immune function. Results obtained in the present investigations are as follows ;
1. Mechanism of stress reaction in the central nervous system
1) We determined different exercise intensities with the anaerobic threshold (AT) as the standard on electroencephalograph and heart rate variability. The results suggest that exercise intensity 20% less than one's AT level has good effects on one's health.
2) We determined combined effects of city noise and the luminance of computer display on human subjects. The results showed high luminance with noise had the greatest effects on subjective fatigue and mental activities.
2. Effects of stress on immune function
1) We determined the effects of physical stress on immune function in rats. The results indicate that the effect of stress on immune function depends on the intensity of stress.
2) We determined zinc concentrations in leukocytes of healthy subjects and patients with NIDDM, one of stress related diseases. There was a significant difference in the zinc concentrations of leukocytes between healthy subjects and patients with NIDDM.