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Non-invasive study on sensorimotor Integration in human gait

Research Project

Project/Area Number 09308031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, Brain Pathophysiology, Professor, 医学研究科, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助手 (90212761)
NAGAMINE Takashi  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助教授 (90181297)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1997: ¥14,000,000 (Direct Cost: ¥14,000,000)
KeywordsGait / Sensorimotor integration / Visual stimulus / Cerebral blood flow / SPECT / MEG / Station / 脳磁場 / 非侵襲的検査
Research Abstract

Ample clinical evidence has indicated that visual information processing plays en essential role in the sensorimotor integration during gait, although the underlying neural mechanisms are scarcely understood. In the recent three years, we have shown that neural system being composed of the lateral premotor-parietal cortex and cerebellum participates in visuomotor integration in gait and relates to the development of paradoxical movement in Parkinson's disease.
Using single photon emission computed tomography (SPECT), we investigated regional cerebral blood flow changes (rCBF) induced by station, gait and visually guided gait in patients with Parkinson's disease and age-matched control subjects. Task-related rCBF images were obtained by injecting ィイD199mィエD1Tc radiotracers during the task performance. Task-related brain activation was determined by statistical parametric mapping. Station-related activation in elderly subjects was observed in the supplementary motor area (SMA), foot prima … More ry motor areas (foot M1), visual cortex, and cerebellar vermis. During gait on a treadmill, elderly subjects showed activation in large mediodorsal frontoparietal areas including SMA and foot M1, visual cortex, dorsal brainstem and cerebellum. In parkinsonian patients, gait-related activation was reduced in the rostral SMA and cerebellar hemisphere, compared with the controls. During gait under visual guidance that improved parkinsonian gait, parkinsonian patients showed enhanced activation in the lateral premotor-parietal cortex and cerebellum. The findings suggest that the lateral premotor cortex, relatively well preserved in function in parkinsonian patients, may undertake the impaired SMA function in gait under the special condition.
Using magnetoencephalograpy (MEG), we examined temporal characteristics of visual evoked signals during motor or nonmotor tasks. The simple visual evoked magnetic responses in the frontal lobe were enhanced in the attention-requiring conditions, suggesting the context-dependent modulation of the frontal visual response. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (115 results)

All Other

All Publications (115 results)

  • [Publications] Hanakawa, T. et al.: "Enhanced lateral remotor activity during paradoxical gait in Parkinson's desease"Ann. Neurol.. 45. 329-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada,K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamono,T. et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishitani,T. et al: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J.Neurosci.. 19. 2647-2657 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toma,K. et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study"J.Neurosci.. 19. 3527-3534 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda,A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of descrimination/selection-related potentials"Brain. 122. 915-931 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima,T. et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-1862 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa,T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa,S. et al.: "Abnormal corticl processing of voluntary muscle relaxation in patients with focal hand dystoia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimazu,H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-2460 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima,T. et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanda,M. et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Murase,N. et al.: "Abnormal premovement gating of somatosensory input in wrier's cramp"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa,S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda,A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunieda,T. et al.: "Different activation of pre-supplementary motor srea(pre-SMA), SMA proper and premary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa, T. et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease."Ann. Neurol.. 45. 329-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Terada, K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles."Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamano, T. et al.: "Abnormal contingent negative variation in writer's cramp."Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishitani, N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit."J. Neurosci.. 19. 2647-2657 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toma, K., et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study."J. Neurosci.. 19. 3527-3534 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda, A., et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials."Brain. 122. 915-931 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima, T. et al.: "Somesthetic function of supplementary motor area during voluntary movements."NeuroReport. 10. 1859-1862 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa, T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study."Brain. 122. 1271-1282 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa, S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials."Brain. 122. 1357-1366 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimazu, H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials."NeuroReport. 10. 2457-2460 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mima, T., et al.: "Brain structures related to active and passive finger movements in man."Brain. 122. 1989-1997 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanda, M., et al.: "Primary somatosensory cortex is actively involved in pain processing in human."Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Murase, N., et al.: "Abnormal premovement gating of somatosensory input in writer's cramp."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa, S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda, A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunieda, T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans."Exp. Brain Res. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hanakawa T.et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-336 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Terada K.et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishitani N.et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 2647-2657 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci,. 19. 3527-3534 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda A.et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"Neuro Report. 10. 1859-1862 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hanakawa T.et al.: "Mechanisms underlying gait disturbance in Parkinson's disease.A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimazu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"Neuro Report. 10. 2457-2460 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mima T.et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanada M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in Press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda A.et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kunieda T.et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujiwara,N.et al.: "Role of the primary auditory cortex in auditory selective attention studied by whole-head neuromagnetometer." Brain Res Cogn Brain Res. 7. 99-109 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukuyama,H.et al.: "Issues in measuring glucose metabolism of rat brain using PET:the effect of harderian glands on the frontal lobe." Neurosci Lett. 255. 99-102 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukuyama,H.et al.: "Neuroimaging findings in Alzheimers disease." Neuropathology. 18. 91-97 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Gerloff,C.et al.: "Cortical activation during fast repetitive finger movements in humans: steady-state movement-related magnetic fields and their cortical generators." Electroenceph.clin.Neurophysiol.109. 444-453 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hamano,T.et al.: "Abnormal contingent negative variation in writer's cramp." Electroencephalogr Clin Neurophysiol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Hanakawa,T.et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease." Ann Neurol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Hanakawa,T.et al.: "Mechanisms underlying gait disturbance in Parkinson's disease.A single photon emission computed tomography study." Brain. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Honda,M.et al.: "Comparative study of event-related potentials and positron emission tomography activation during a paired-associate memory paradigm." Exp Brain Res. 119. 103-115 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Focal ictal DC shifts in human epilepsy as studied by subdural and scalp recording." Brain. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Role of mesial temporal lobe in voluntary movements: Bereitschaftspotential study in epileptic patients after left antero-mesial temporal resection." Electroencephalogr Clin Neurophysiol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related cortical potentials." Brain. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Clonic convulsion caused by epileptic discharges arising from human supplementary motor area(SMA)as studied by subdural recordings." Epileptic Disord. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanda,M.et al.: "Cortical mechanisms underlying point localization of pain spot as studied by event-related potentials following CO2 laser stimulation in man." Exp Brain Res. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura,K.et al.: "Sleep-disordered breathing at an early stage of amyotrophic lateral sclerosis." J Neurol Sci. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Mima,T.et al.: "Attention modulates both primary and second somatosensory cortical activities in humans: a magnetoencephalographic study." J Neurophysiol. 80. 2215-2221 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagahama,Y.et al.: "Neural activity during attention shifts between object features." Neuroreport. 9. 2633-2638 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura,M.et al.: "Realization of artificial intelligenece for integrative electroencephalogram interpretation." Artif Life Robotics. 2. 91-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishitani,N.et al.: "Modality-specific subregions in human inferior parietal lobule: a magnetoencephalographic study during cognitive tasks." Neurosci Lett. 252. 79-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishitani,N.et al.: "Role of hippocampus in auditory processing studied by event-related electric potentials and magnetic fields before and after temporal lobectomy." Brain. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Shindo,K.et al.: "Clinical usefulness of the dipole tracing method for localizing interictal spikes in partial epilepsy." Epilepsia. 39. 371-379 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Terada,K.et al.: "Movement-related potential associated with voluntary relaxation of foot muscles." Electroencephalogr Clin Neurophysiol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Toma,K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study." J Neurosci. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Yazawa,S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia as studied by movement-related potentials." Brain. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村政俊 他: "脳波中瞬目アーチファクトの選択的正規化加算平均による除去法." 医用電子と生体工学. 36. 359-364 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tassinari,C.A.et al.: "Invited Review: Neurophysiology of positive and negative myoclonus." Electroencephalogy Clin Neurophysiol. 107. 181-195 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shibasaki,H.: "Myoclonus and startle syndrome." In Parkinson's Disease and Movement Disorders,3rd ed.,(eds.by Jankovic,J.and Tolosa,E.),Williams & Wilkins,Baltimore,. 453-466 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shibasaki,H.: "Nonhereditary myoclonic epilepsy." In The Epilepsies: Etiologies and Prevention(eds.by Kotagal,P.and Lueders,H.O.),Academic Press,. 417-420 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Dong,Y.et al.: "Assessment of benzodiazepine receptors using lodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease A comparison with PET study" Stroke. 28. 1776-1782 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukuyama,H.et al.: "Brain functional activity during gait in normal subjects : A SPECT study." Neurosci Lett.288. 183-186 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukuyama,H.et al.: "Effects of extracranial radioactivity on measurement of cerebral glucose metabolism by Rat-PET with [18F]-2-fluoro-2-deoxy-D-glucose." J.Cereb.Blood Flow Metab.17. 1261-1262 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hamano,T.et al.: "The cortical generators of the contingent negative variarion in humans : a study with subdural electrodes." Electroenceph.clin.Neurophysiol.104. 257-268 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirano,S.et al.: "Cortical activation by monaural speech sound stimulation demonstrated by positron emission tomography." Exp.Brain Res.113. 75-80 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirano,S.et al.: "Cortical processing mechanism for vocalization with auditory verbal feedback" NeuroReport. 8. 2379-2392 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Honda,M.et al.: "Movement-related cortical potentials and regional cerebral blood flow change in patients with stroke after motor recovery" J.Neurol.Sci.146. 117-126 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Dissociation between contingent negative variation (CNV) and Bereitschaftspotential (BP) in patients with parkinsonism" Electroenceph.clin.Neurophysiol.102. 142-151 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Alopecia with carbamazepine in two patients with focal seizures." J Neurol Neurosurg Psychiatr.63. 549-550 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Scalp-recorded focal,ictal DC shift in a patient with tonic seizure" Epilepsia. 38. 1350-1354 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Reappraisal of the effects of electrode property on recording slow potentials." Electroenceph.clin.Neurophysiol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda,A.et al.: "Role of mesial teporal lobe in voluntary movements : Bereitschaftspotential study in epileptic patients after left antero-mesial temporal resection" Electroenceph.clin.Neurophysiol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Kojima,H.et al.: "The role of the temporal coding system in the auditory cortex on speech recognition." NeuroReport. 8. 2395-2398 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lai,C.et al.: "Event-related potentials associated with judgment : Comparison of S1-and S2-choice conditions in a contingent negative variation (CNV) paradigm" J.Clin.Neurophysiol.14. 394-405 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lu,C.et al.: "Electrophysiological studies of early stage corticobasal degeneration" Mov.Disord.13. 140-146 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mikuni,N.et al.: "Simultaneous recording of epileptiform discharges by MEG and subdural electrodes in temporal lobe epilepsy" Neuroimage. 5. 298-306 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mikuni,N.et al.: ""Cavernous sinus" EEG : a new method for the preoperative evaluation of temporal lobe epilepsy." Epilepsia. 38. 472-482 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mikuni,N.et al.: "Frontopolar ictal epileptiform discharges on scalp EEG in temporal lobe epilepsy" J.Clin.Neurophysiol.14. 507-512 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mima,T.et al.: "Human second somatosensory area : subdural and magnetoencephalographic recording of somatosensory evoked responses" J.Neurol.Neurosurg.Psychiatry. 63. 501-505 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mima,T.et al.: "Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs." Electroenceph.clin.Neurophysiol.104. 51-59 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mima,T.et al.: "Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicorotical recording" Electroenceph.clin.Neurophysiol.104. 103-107 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mima,T.et al.: "Pathogenesis of cortical myoclonus studied by magnetoencephalography" Ann.Neurol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Mima,T.et al.: "Cortical myoclonus : sensorimotor hyperexcitability" Neurology. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagahama,Y.et al.: "Age-related changes in cerebral blood flow activation during a Card Sorting Test." Exp.Brain Res.114. 571-577 (1997)

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      1997 Annual Research Report
  • [Publications] Yamauchi,H.et al.: "Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion.A PET study." Stroke. 29. 98-103 (1998)

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      1997 Annual Research Report
  • [Publications] Yamauchi,H.et al.: "Atrophy of the corpus callosum,cortical hypometabolism,and cognitive impairment in corticobasal degeneration." Arch Neurol. (in press).

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  • [Publications] Yazawa,S.et al.: "Subdural recording of Bereitschaftspotential is useful for functional mapping of the epileptogenic motor area,a case report." Epilepsia. 38. 245-248 (1997)

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  • [Publications] Yazawa,S.et al.: "Cortical mechanism underlying externally cued gait initiation studied by contingent negative variation" Electroenceph.clin.Neurophysiol.105. 390-399 (1997)

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  • [Publications] Yazawa,S.et al.: "Supplementary motor area is active in preparation for both voluntary muscle relaxation and contraction : subdural recording of Bereitschaftspotential" Neurosci.Lett.(in press).

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  • [Publications] 葛谷 聡 他: "Jerk-locked back averaging(JLA)法によっててんかん発作時焦点が確認された補足運動野発作の一症例" 臨床神経. 37. 923-926 (1997)

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  • [Publications] 杉 剛直 他: "安静閉眼時背景脳波の徐波特性 定量判読" 医用電子と生体工学. 35. 95-99 (1997)

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  • [Publications] 中村政俊 他: "脳波モデルを介した徐波律動特性の定量解析" 医用電子と生体工学. 35. 392-399 (1997)

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  • [Publications] Nagahama,Y.et al.: "Cerebral glucose metabolism in corticobasal degeneration : Comparison with progressive supranuclear pasly and nomal controls" Mov.Disord.12. 691-696 (1997)

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  • [Publications] Nagamine,T.et al.: "Serial processing of the somesthetic information revealed by defferent effects of stimulus rate on the somatosensory evoked potentials and magnetic fields" Brain Res.(in press)

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  • [Publications] Nishitani,N.et al.: "Cortical-hippocampal auditory processing identified by magnetoencephalography" J.Cog.Neurosci.in press

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  • [Publications] Shindo,K.et al.: "Clinical usefulness of dipole tracing method for localizing interictal spikes in partial epilepsy" Epilspsia. (in press)

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  • [Publications] Tanaka,F.et al.: "Presurgical identification of epilepstic foci with iodine-123 iomazenil SPECT : comparison with brain perfusion SPECT and FDG-PET." Eur.J.Necl.Med.24. 27-34 (1997)

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  • [Publications] Terada,K.et al.: "Familial cortical myoclomic tremor as a unique form of cortical reflex myoclonus" Mov.Disord.12. 370-377 (1997)

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  • [Publications] Tsukada,H.et al.: "Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition : a positron emission tomography study in unanesthetized monkeys." J.Pharmacol.Exp.Ther.281. 1408-1414 (1997)

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  • [Publications] Yamauchi,H.et al.: "Atrophy of the corpus callosum,cognitive impairment and cortical hypometabolism in progressive supranuclear palsy." Ann.Neurol.41. 606-614 (1997)

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Published: 1997-04-01   Modified: 2016-04-21  

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