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Tissue-Engineered Cardiovascular Tissues

Research Project

Project/Area Number09357014
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Thoracic surgery
Research InstitutionKYUSHU UNIVERSITY(1998-1999)
National Cardiovascular Center Research Institute(1997)

Principal Investigator

MATSUDA Takehisa  Dept. Bioengineering, Graduate School of Medicine Kyushu University, Professor, 大学院・医学系研究科, 教授 (60142189)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Yasuhide  Department of Bioengineering, National Cardiovascular Canter Research Institute, 生体工学部, 室長 (50250262)
増田 慎介  国立循環器病センター研究所, 生体工学部, レジデント研究員
高見沢 計一  国立循環器病センター研究所, 生体工学部, 室員 (10163312)
中谷 武嗣  国立循環器病センター研究所, 生体工学部, 室長 (60155752)
関 淳二  国立循環器病センター研究所, 生体工学部, 室長 (20163082)
Project Period (FY) 1997 – 1999
Project Status Completed(Fiscal Year 1999)
Budget Amount *help
¥17,900,000 (Direct Cost : ¥17,900,000)
Fiscal Year 1999 : ¥3,400,000 (Direct Cost : ¥3,400,000)
Fiscal Year 1998 : ¥4,500,000 (Direct Cost : ¥4,500,000)
Fiscal Year 1997 : ¥10,000,000 (Direct Cost : ¥10,000,000)
KeywordsTissue Engineering / Extracelluar Matrix / Biomaterial / Surface Design / 人工素材 / サイトカイン / 人工組織外マトリックス / 細胞
Research Abstract

Hybrid tissues engineering focusing on the functional replacement of diseased tissues has been conducted from various aspects of engineering, biology and medicine. The molecular design, biomechanical scaffold designs and cellular biomechanical were newly developed and consolidated to develop a solid basis of tissue-engineered functional devices.

Report

(4results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report

Research Products

(23results)

All Other

All Publications

  • [Publications] Y. Nakayama and T. Matsuda: "Photocurable Surgical Tissuse Adhesive Glues Composed of Photoreactive Getatir…"J. Biomed Mater Res (Appl Biomater). 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Matsuda, R. E., Marchant, J. Higashi, Y. Nakayama: "High-Spatiotesolved Microarchitectual Surface Prepared by Photograft…"Langmuir. 15. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama, M. Miyamuta, Y. Hirano, K. Goto, T. Matsuda: "Prepartion of poly(ethylene glycol)-polystyrene block copdymers…"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Saito, T. Matsuda: "Protain adsorption on self-assembled monolayers with water…"Materials Science & Engineering. C6. 261-266 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama, T. Matsuda: "In Situ Observation of Dethiocarbamate-Based Surface Photograft…."Macromolecules. 16. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Makayama and Tekehisa Matsuda: "Photocurable Surgical Tissue Adhesive Glues Composed of Photoreactive Gelatin and Poly (ethylene Glycol) Diacrylate"J. Biomed Mater Res. (Appl Biomater). 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.Higashi, Y.Nakayama, R.E, Marchant and T.Matsuda: "High-Spatioresolved Microarchitectual Surface Prepared by Photograft Copolymerization Using Dithiocarbamate : Surface Preparation and Cellular Responses"Langmuir. 15, 6. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Nakayama, M.Miyamura, Y.Hirano, K.Goto,T. Matsuda: "Preparation of poly (ethylene glycol)-Polystytrene block copolymers using photochemistry of dithiocarbamate as a reduced cell-adhesive coating material"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noboru Saito, Takehisa Matsuda: "Protain adsorption on self-assembled monolayers with water-soluble non-ionic oligomers using quartz crystal microbalance"Materials Science & Engineering. C6. 261-266 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Nakayama and T.Matsuda: "In Situ Observation of Dethiocarbamate-Based Surface Photograft Copolymazation Using Quartz Crystal Microbalance"Macromolecules. 32, 16. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Nakayama and T.Matsuda: "Photocurable Surgical Tissue Adhesive Glues Composed of Photoreactive Getatir・・・"J.Biomed Mater Res(Appl Biomater). 48. 511-521 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Matsuda,R,E,Marchant J,Higashi, Y,nakayama: "High-Spatioresolved Microatchitecctual Surface Prepared by Photograft・・・"Langmuir. 15. 2080-2088 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Nakayama,M.Miyamura,Y,Gurano K,Goto,T,Matsuda: "Preparation of poly(ethylene glycol)-polystyrene block copdymers・・・"Biomaterials. 20. 963-970 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N,Saito.T.Matsuda: "Protain adsorption on self-assembled monolayers with mater・・・"Materials Science & , Engineering. C6. 261-266 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Nakayama,T,Matsuda: "IN Situ Observation of Dethiocarbamate-Based Surface photopaft・・・"Macromolecules. 16. 5405-5410 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Heung Jae Lee Takenlsa Matsuda: "Surface Photograft polymerization on Segmented・・・"Journal of Biocmedial Materials Research. 47. 564-567 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Heung,J.Lee,Y,Nakagama,T,Matsuda: "Spatio-Pesolved,Mocromolecul ar Architoctural."Macromolecules. 32. 6985-6995 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Okano and T.Matsuda: "Tissue Engineered Skaletal Muscle:Preparation of highly Dense,Highly Oriented Hybrid Muscular Tissues" Cell Transplantaion. 7・1. 71-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Nakayama,K.Nakamata,Y.Hirano,K.Goto,and T.Matsuda: "Surface Hydrogelation of Thiolated Water-Soluble Copolymerson Bold" Langmuir. 14・14. 3909-3915 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Okano and T.Matsuda: "Muscular Tissue Engineering:Capillary-Incorporated Hybrid Muscular Tissue viro Tissue Culture" Cell Transplantation. 7・5. 435-442 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kiyoshi Doi and Takehisa Matsuda: "Enhanced vascularization in a microporous polyurethane graft impregnated with basic fibrolastgrouwth factor and heparin" Jounal of Biomedical Materials Research. 34. 361-370 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masami Tanahashi and Takehisa Matsuda: "Surface functional group dependence on apatite foumation on self-assembled monolayers in a simulated body fluid" Jounal of Biomedical Material Recearch. 34. 305-315 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahisa Okano and Takehisa Matsuda: "Hybrid Muscular Tissues:Preparation of Skeletal Muscle Cell-Incorporated Collagen Gels" Cell Transplantation. 6,2. 109-118 (1997)

    • Related Report
      1997 Annual Research Report

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Published : 1997-04-01   Modified : 2016-04-21  

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