SEYAMA Yoshiyuki Hoshi College of Pharmacy, Professor, 臨床化学教室, 教授 (90061283)
IITOI Yuji Collage of Tokyo Univ. of Agri., Associate Professor, 短期学部・栄養学科, 助教授 (20078215)
AKABANE Masayuki Junior Collage of Tokyo Univ. of Agri., Professor Emeritus, 短期学部・栄養学科, 名誉教授 (50078135)
IWASAKI Masae Tokyo Univ. of Agri., Research Associate Professor, 応用生物科学部, 助手 (70266881)
IWAMA Masahiko Tokyo Univ. of Agri., Assistant Professor, 応用生物科学部, 講師 (10168594)
高橋 東生 東京農業大学短期大学部, 栄養学科, 助手 (30289920)
|Budget Amount *help
¥1,100,000 (Direct Cost : ¥1,100,000)
Fiscal Year 1998 : ¥1,100,000 (Direct Cost : ¥1,100,000)
To clarify the associations between local dietary habits and disease risks, hepatic enzyme system of drug metabolism and aortic connective tissue component levels were investigated in rats fed the complete human diet consumed in the two Japanese prefectures, Akita (A) and Okinawa (O), where the incidence of cancers was quite different : Okinawa had the lowest and Akita the highest age-adjusted mortality rate.
Male Wistar rats were divided into three groups of 10 animals each : the first (control, C) group was fed the MF animal diet (Oriental Yeast, Tokyo, Japan), the second (Akita, A) group the freeze-dried powder from Akita's meals, and the third (Okinawa, O) group the mill of Okinawa's meals.
After animals were given the corresponding diets for eight weeks, the final body weight of the O diet group was significantly higher than that of the A diet group, presumably because of the difference in food efficiency.
However, there were no changes between two groups in the hepatic drug-metabolizing enzyme system (cytochrome P-450 content and activities of sulfotransferase, UDP-glucuronyltransferase, glutathione S-transferase) and aortic connective tissue component levels (collagen, elastin and cholesterol). Moreover, the CClィイD24ィエD2 treatment changed, regardless of human (A and O) diets, the serum and hepatic enzyme levels.