| Project/Area Number |
09670381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
SOKEJIMA Shigeru Toyama Medical and Pharmaceutical University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (40262513)
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| Co-Investigator(Kenkyū-buntansha) |
MURAI Yoshihiro Toyama Medical and Pharmaceutical University, Faculty of Medicine, Research Associate, 医学部, 助手 (60115194)
KITAGAWA Masanobu Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (40010003)
SAKAI Hideo Toyama Universityd, Faculty of Science, Associate Professor, 理学部, 助教授 (30134993)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Lung Cancer / Tissue Sample / Remanent Magnetization / Superconducting Quantum Interference Device (SQUID) / 肺癌 / 肺組織標本 / 磁化強度 |
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| Research Abstract |
Remanent magnetization of lung tissues of 14 cases of lung cancers and 11 cases of other patients was studied using Superconducting Quantum Interference Device (SQUID). Natural remanent magnetization (NRM) of the specimen from lung cancer tissue (8.00 ± 13.11 × 10ィイD1-7ィエD1 emu) was two times stronger than that of the normal lung tissue (3.35 ± 3.35 × 10ィイD1-7ィエD1 emu), and was significantly stronger than that of the controls and the noise level of superconducting magnetometer. When comparing the NRM of 5 kinds of tissues from other patients, lung tissues had the highest value, followed by heart, spleen and kidney. Liver tissue had the lowest value. NRM of all the 5 tissues were stronger than that of controls, indicating that the normal tissues contained the magnetic materials. The biological magnetite is the possible magnetic material in these tissues. Two cases of specimens with highly magnetized lung cancer tissue are especially studied on their magnetic properties. Alternating fiel
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d demagnetization experiment shows that the magnetization of them is a stable one vector component which indicates that the lung tissue may have been magnetized after the accumulation of the magnetic materials. Wohlfarth ratio of them is determined as the value less than 0.5, suggesting that the magnetic materials exist in the lung tissue as the cluster distribution.
The meta-analysis was Used to summarize the results of epidemiological studies on the relationship between occupational exposure to an electromagnetic field (EMF) and the risk of adult leukemia. The combined relative risk of all leukemia (RR=1.11), as well as acute lymphocytic leukemia (RR=1.38), acute myeloid leukemia (RR=1.07) and chronic lymphocytic leukemia (RR=1.14) increased but not significantly. So far, it is difficult to make a consistent conclusion about the relationship of the occupational exposure to EMF and adult leukemia. Further carefully designed case-control and cohort studies using the more valid means of exposure assessment are required. Less
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