Basic research on "Pericardial pumping" as a circulatory assist device
Project/Area Number |
09670734
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
MORIKAWA Junichiro Kyoto Prefectural University of Medicine, Third Department of Internal Medicine, assistant, 医学部, 助手 (80244614)
|
Project Period (FY) |
1997 – 1998
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Project Status |
Completed (Fiscal Year 1998)
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Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
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Keywords | circulatory assist device / assister cup / sphygmomanometer cuff / volume respirator / left ventricular pressure / aortic flow volume / 心マッサージ法 / 経食道心エコー / 前後方向圧迫 / 左右方向圧迫 / 僧帽弁逆流 / 心外膜腔補助循環法 / マンシェット / 超音波血流計 |
Research Abstract |
Background. The lack of a simple and safely applicable surgical strategy for refractory heart failure, designed to apply forces directly to the ventricular walls, led us to revise the assister cup proposed in the 1960's and develop a system consisting of a sphygmomanorneter cuff wrapped around the heart. Methods. A cuff measuring 3 cm wide was wrapped around both ventricles in twelve rabbits and pneumatically inflated and deflated cyclically during induced ventricular fibrillation using a volume respirator as the power unit. Results. Mean peak left ventricular pressure increased from 62.1*23.5 mmHg at the control to 75.5*20.0 mmHg during cuff assistance (p=0.054). Mean peak aortic flow volume decreased from 401.7*258.7 ml/min to 303.6*155.2 ml/min (p=0.070). Mean stroke volume, however, increased from 0.38*0.26 ml to 0.52*0.20 ml (p=0.025). Post-mortem study did not show any ecchymosis or bleeding. Conclusions. Advantages in cuff assistance include simplicity without vessel cannulation or contact with blood and superior fitting due to the flexibility of the material. Moreover, it has potential as a bridge to myocardial recovery.
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Report
(3 results)
Research Products
(3 results)