|Budget Amount *help
¥3,100,000 (Direct Cost : ¥3,100,000)
Fiscal Year 2000 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1999 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1998 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1997 : ¥1,400,000 (Direct Cost : ¥1,400,000)
To study clinical validity of DSM-IV childhood disintegrative disorder (CDD), 10CDD children (M=7.7 years ; 7 male, 3 female), 11 (M=6.5 years ; 9 male, 2female) with ICD-9 disintegrative psychosis (DP) diagnosed as DSM-IV autistic disorder (AD)(DP-AD), 7 (M=6.1 years ; 5 male, 2 female) with DP diagnosed as DSM-IV PDDNOS (DP-PDDNOS), and 82 (M=5.9 years ; 62 male, 20 female) with AD with speech loss (ASL) were compared on 16, 8, and 24 variables before, during, and after regression, respectively. Among the 4 groups without significant difference in age and sex ratio, 12 variables showed a significant difference by post hoc comparisons. Before regression, CDD was significantly stronger in separation anxiety around age one than ASL, more common to use finger pointing than DP-PDDNOS and ASL, and better in bladder control than DP-AD and ASL.ASL was significantly less frequent to use a two-word phrase and earlier to lose speech than the other 3, and less common in normal relationship than CDD and DP-AD.During regression, CDD significantly more frequently lost finger pointing than ASL and bladder control than DP-AD and ASL.ASL showed significantly less commonly fearfulness than the other 3. After regression, CDD showed epilepsy and stereotypy significantly more frequently than ASL.DP-PDDNOS showed significantly milder verbal communication disturbance than ASL.The autistic tendency and rate of children with IQ<35 did not differ significantly among the 4 groups. Although CDD was better in development before regression and clearer in regression, its difference in development and autistic tendency from ASL disappeared and its differences from DP-AD and DP-PDDNOS decreased about 4 years after regression. CDD has clinical validity. Its developmental outcome may not be different from that of ASL occupying 20 to 40 % of the autism population.