|Budget Amount *help
¥1,300,000 (Direct Cost : ¥1,300,000)
Fiscal Year 1998 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1997 : ¥800,000 (Direct Cost : ¥800,000)
It is important to study the relationship between serum concentration of antidepressants and clinical response. In most studies total concentartion of antidepressants was determined. However the effect of antidepressant is related to free or unbound drug concentration. The purpose of current study was to clarify the relationship between free concentration of antidepressant and clinical response and to determine clinical predictors to antidepressants.
We determined serum concentration of clomipramine (CMI) and its metabolites, desmetylclomipramine, hydroxyclomipramine and desmethyhydroxyclomipramine by high performance liquid chromatography with UV detector.
Patients included males and females who were experiencing a major depressive episode diagnosed according to DSM-III-R criteria. Patients were received CMI, 75 mg/day for three days and 150 mg/day for 4 weeks. The Hamilton Rating Scale for Depression (HRSD) was used throught the investigation.
If the HIRSD at 4 weeks >=50%, a patient was classified as a responder.
Of 25 inpatients treated with CMI , 11 patients responded, whereas 14 patients did not respond. There were significant differences of age, gender between two groups.
The difference of serum concentration between two groups, relationship between free serum concentration of CMI and clinical response , and clinical predictors are analyzing at present.