EFFECTS OF ENDOTOXEMIA ON NEUROMUSCULAR FUNCTION IN RATS
Project/Area Number |
09671539
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | GUNMA UNIVERSITY SCHOOL OF MEDICINE |
Principal Investigator |
MORITA Toshihiro GUNMA UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF ANESTHESIOLOGY AND REANIMATOROGY, ASSOCIATE PROFESSOR, 医学部, 助教授 (30143233)
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Project Period (FY) |
1997 – 2000
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Project Status |
Completed (Fiscal Year 2000)
|
Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
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Keywords | ACETYLCHOLINE RECEPTOR / MUSCLE / NEUROMUSCULAR FUNCTION / ANTI-ACETYLCHOLINE RASTER / MYASTHENIA GRAVIS / INFECTION / Cecal ligation and puncture / d-tubocurarine / 筋力低下 / nicotinic acetylcholine receptor / anti-nicotinic acetylcholine receptor antiboc / downregulation / weakness / chronic infection / エンドトキシン / dツボクラリン / FR1676523 / ED50 |
Research Abstract |
Systemic inflammation resulting from burns induces upregulation of muscle acetylcholine receptors (AChR). On the other hand, chronic infections such as Chagas disease are complicated myasthenia gravis (MG). The current research was performed how the experimental system of cecal ligation puncture (CLP), a rat model of bacterial sepsis resembling the clinical situation of an infection with a mixed bacterial flora of intestinal origin, could affect the AChR.CLP produced a myasthenia-like syndrome during the recovery phase of CLP-induced systemic inflammation. Features included muscular weakness, downregulation of AChR in both the anterior tibial muscle and diaphragm, detectable levels of at least two types of anti-AChR antibodies (blocking and nonblocking antibodies) in serum, increased sensitivity to d-tubocurarine, and mechanomyographic decremental responses after low rates of nerve stimulation and the reversibility by neostigmine. Stefanson et al. have reported that intestinal bacteria may induce autoimmune responses through shared determinants between the AChR and bacterial proteins. Our observations should be considered in the context of the proposed association between infections and MG.
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Report
(5 results)
Research Products
(11 results)