|Budget Amount *help
¥1,800,000 (Direct Cost : ¥1,800,000)
Fiscal Year 1999 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1998 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1997 : ¥800,000 (Direct Cost : ¥800,000)
Adriamycin ( ADM ) is a cytostatic antibiotic which is widely used in the treatment of malignant tumor. It is reported that ADM is carried by retrograde axonal transport and causes the degeneration of neurons. We select alcohol or phenol is selected in neurolytic blocks. But, we could seldom use those drugs with the patients of leg pains accompanied by spinal injury or trigeminal postherpetic neuralgias. Because the injured regions were dorsal horn and dorsal root, it was difficult to insert nerve block needles. Even if ADM is injected at the peripheral regions, the effects of ADM may reach dorsal horn and dorsal root. If the character of ADM is utilize, it will relieve those patients. The purposes of this research were 1) the production of hyperesthesia models, 2) whether ADM relieves the hyperesthesia and 3) whether ADM causes heperesthesia. Sprague - Dawley rats were used.
1) We assessed the model of ligature ( group A ) or amputation ( group B ) of the right sciatic nerve. The right
sciatic nerve of group A was ligatured loosely using Vicryl (3-0)ィイD1TMィエD1 and the right sciatic nerve of group B was cut. Both of groups were given laser stimuli ( plantar test ) at the right planta ( treatment side ) and the left side ( control side ). Using plantar test, we compared with the time from the starting of stimuli to escape ( pain threshold). The tests were done before treatment, one week, three weeks and four weeks after treatment. The results were that thresholds of treatment side in group A decreased significantly ( one week, three weeks and four weeks after treatment ), and thresholds of treatment side in group B increased significantly ( one week after treatment ). The ligature of sciatic nerve caused hyperesthesia of the planta.
2) ADM was injected at the distal region of the ligatured site in ligatured models. The injection of ADM was done after two weeks after treatment. The plantar tests were done before treatment, one week, three weeks and four weeks after treatment. After injection of ADM hyperesthesia disappeared. ADM might relive hyperesthesia.
3) The injection of ADM only did not change the plantar test. But some rats were made motor palsy of right legs by ADM. Less